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Manchester Centre for Biological Timing

@biologicaltimemcr.bsky.social
50 followers 82 following 41 posts

The University of Manchester is home to the largest biological timing research community in Europe. We bring together world-leading researchers with a multidisciplinary approach to cellular timers and circadian clocks.

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Manchester Centre for Biological Timing @biologicaltimemcr.bsky.social · 10/09/2026
Suggested read: Caloric restriction modulates genome-wide somatic mutation in mice www.sciencedirect.com/science/arti...
sciencedirect.com
Caloric restriction modulates genome-wide somatic mutation in mice
Somatic mutations accumulate throughout life in every cell, and this process constitutes one of the hallmarks of aging—genomic instability. Caloric re…
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Manchester Centre for Biological Timing @biologicaltimemcr.bsky.social · 09/09/2026
New paper from Eder Zavala's team at the CfBT Regulation of ultradian pulsatility and stress responses in the human hypothalamic–pituitary–adrenal axis onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com
<em>Journal of Neuroendocrinology</em> | BSN Journal | Wiley Online Library
The hypothalamic–pituitary–adrenal (HPA) axis is a vital neuroendocrine system that maintains homeostasis by regulating stress hormone secretion through tightly controlled circadian and ultradian rhy...
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Manchester Centre for Biological Timing @biologicaltimemcr.bsky.social · 27/08/2026
A new study from CfBT's Future Leaders Fellow Eder Zavala, published today in Science Translational Medicine! www.science.org/doi/10.1126/... #PrimaryAldosteronism #Hypertension #Endocrinology #CircadianRhythms #DigitalHealth #WearableTechnology #MathematicalBiomedicine
science.org
Tissue corticosteroid rhythms are dysregulated predominantly during sleep in primary aldosteronism
Ambulatory 24-hour microdialysis reveals disrupted corticosteroid rhythms in primary aldosteronism.
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Manchester Centre for Biological Timing @biologicaltimemcr.bsky.social · 10/08/2026
Jafar Cain's PhD work published! The club cell circadian clock regulates temporal patterns in leukocyte... www.sciencedirect.com/science/arti...
sciencedirect.com
The club cell circadian clock regulates temporal patterns in leukocyte trafficking in chronic allergic airways disease
Patients with allergic asthma exhibit distinct temporal variations in symptoms and disease severity, which oscillate across the 24 h day. We have prev…
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Manchester Centre for Biological Timing @biologicaltimemcr.bsky.social · 02/07/2026
New invited review published by our Centre in The Journal of Biochemistry! Nutrigenomic Regulation of One-Carbon Metabolism and the Circadian Clock in Health and Disease academic.oup.com/jb/article/d...
academic.oup.com
Nutrigenomic Regulation of One-Carbon Metabolism and the Circadian Clock in Health and Disease
Abstract. Methylation of DNA, histones, and RNA is central to the regulation of circadian rhythms, yet the biochemical origin of the methyl groups driving
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Manchester Centre for Biological Timing @biologicaltimemcr.bsky.social · 08/06/2026
Prof Hannah Durrington contributed to an article in The New York Times (account required to read)! www.nytimes.com/2026/06/04/c...
nytimes.com
Bright City Lights Might Be Making Your Allergies Worse
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Manchester Centre for Biological Timing @biologicaltimemcr.bsky.social · 27/04/2026
We are delighted to welcome John O'Neill at the CfBT on the 22nd May!
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Manchester Centre for Biological Timing @biologicaltimemcr.bsky.social · 01/05/2026
That's one of ours! Look at these enormous heatmaps!
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Manchester Centre for Biological Timing @biologicaltimemcr.bsky.social · 27/04/2026
We are delighted to welcome John O'Neill at the CfBT on the 22nd May!
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Abi pienaar @abipienaar.bsky.social · 21/04/2026
How do circadian clocks shape how we see? I'll be presenting at this online event on Thursday, so come along if want to find out! Free for BNA members@dns-uom.bsky.social @biologicaltimemcr.bsky.social
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Manchester Centre for Biological Timing @biologicaltimemcr.bsky.social · 20/04/2026
New paper from our Centre! The impact of self-selected light on activity rhythms in the diurnal striped mouse: Current Biology www.cell.com/current-biol...
cell.com
The impact of self-selected light on activity rhythms in the diurnal striped mouse
Hughes et al. allow day-active striped mice control over their home-cage light exposure, investigating the impact of self-selected light on daily activity rhythms. These mice prefer bright light when ...
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Reposted by Manchester Centre for Biological Timing
FEBS Letters @febsletters.bsky.social · 30/03/2026
🔔 Our latest special issue, guest edited by Prof. Carrie Partch, is now live! Featuring: ⏰ The latest advances in our understanding of the molecular basis of circadian rhythms ⏱️ Circadian rhythms' pervasive and powerful control of biology ⌚ And — new frontiers in the field. ▶️ tinyurl.com/3a7nr7je
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Manchester Centre for Biological Timing @biologicaltimemcr.bsky.social · 02/02/2026
On BBC radio 4,Dr Gareth Kitchen shared with us insights on his latest publication in Anaesthesia: www.bbc.co.uk/sounds/play/...
bbc.co.uk
Today - 10/01/2026 - BBC Sounds
Including Sports Desk, Weather and Thought for the Day.
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Manchester Centre for Biological Timing @biologicaltimemcr.bsky.social · 02/02/2026
New publication for the CfTB! Time of day of cardiac surgery and postoperative outcomes in the UK: a secondary analysis of linked national datasets associationofanaesthetists-publications.onlinelibrary.wiley.com/share/VKP7YS...
associationofanaesthetists-publications.onlinelibrary.wiley.com
Time of day of cardiac surgery and postoperative outcomes in the UK: a secondary analysis of linked national datasets
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Samer Hattar @samerhattar.bsky.social · 07/01/2026
A new paper from my lab. I will have a full description soon. rdcu.be/eX1Ld
rdcu.be
ipRGC properties prevent light from shifting the SCN clock during daytime
Nature - The inability of intrinsically photosensitive retinal ganglion cells to shift the circadian clock in the suprachiasmatic nucleus during daytime is caused by light-dependent depolarization...
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Manchester Centre for Biological Timing @biologicaltimemcr.bsky.social · 05/01/2026
Wishing the international circadian community a Happy New Year! 🌍⏰ May your 2026 be filled with stable rhythms, bright zeitgebers, and groundbreaking discoveries. Here’s to another 365 cycles together! 🥂 #Chronobiology #CircadianRhythms
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Manchester Centre for Biological Timing @biologicaltimemcr.bsky.social · 27/11/2025
Registration is open for the SRBR 2026 Biennial Meeting to take place on May 9-13, 2026 - Amelia Island, FL. Early career scientists and PhD students are encouraged to apply. Share you discoveries! srbr.societyconference.com/v2/
srbr.societyconference.com
Conference Home Page
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Manchester Centre for Biological Timing @biologicaltimemcr.bsky.social · 25/11/2025
The CfBT welcomes Eder Zavala @ederzavala.bsky.social as a new PI! Eder is a UKRI Future Leaders Fellow; his group’s research lies at the interface of mathematics, physiology, and medicine, using quantitative models and data-driven approaches to reveal how hormonal dynamics shape human health.
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Manchester Centre for Biological Timing @biologicaltimemcr.bsky.social · 20/11/2025
New database of c-Fos Circadian Expression in Whole Mouse Brain by Hiroki Ueda, to use at will and freely! circadian.cfosdb.systems-based-medicine.org/database/
circadian.cfosdb.systems-based-medicine.org
Home
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Society for Light, Rhythms, and Circadian Health @slrch-society.bsky.social · 03/11/2025
💡Need more light science in your life?💡 🚨Check out Daylight Awareness Week 3-7 November 2025 by the Daylight Academy! 🌟This year’s Daylight Awareness Week explores how daylight can help build healthier, more sustainable, and fairer societies daylight.academy/daylight-awa...
daylight.academy
Daylight Awareness Week 2025 - Daylight Academy
3-7 November 2025 Celebrate daylight with us!
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Society for Light, Rhythms, and Circadian Health @slrch-society.bsky.social · 20/11/2025
☀️ Exciting developments coming soon from SLRCH for our early career folks! Stay tuned! ☀️
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Manchester Centre for Biological Timing @biologicaltimemcr.bsky.social · 11/11/2025
@airwayamlan.bsky.social will give a seminar at Pints with Parse on the 20th November, speaking about biological timing and asthma! More details at resources.parsebiosciences.com/pints-with-p...
resources.parsebiosciences.com
Pints with Parse Manchester
Join Parse Biosciences for a happy hour networking event at Victoria Baths in Manchester.
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Manchester Centre for Biological Timing @biologicaltimemcr.bsky.social · 16/09/2025
Dr Hannah Durrington @h_durrington is featured in a film made by Asthma and Lung UK about time of day in asthma diagnosis and treatment! Watch at: vimeo.com/1117260180/0...
vimeo.com
Hannah Durrington_9x16 Social_FINAL
This is "Hannah Durrington_9x16 Social_FINAL" by Asthma + Lung UK on Vimeo, the home for high quality videos and the people who love them.
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Manchester Centre for Biological Timing @biologicaltimemcr.bsky.social · 01/09/2025
12 CfBT representatives and associates presented talks and posters at the European Biological Rhythms Society 2025 congress ebrs-online.org/index.php/ev...
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Manchester Centre for Biological Timing @biologicaltimemcr.bsky.social · 12/08/2025
Rob Lucas, Bea Bano Otalora and Tim Brown recipients of a Wellcome Trust Discovery award to study the mechanisms by which light across daytime shapes daily profiles of sleep and influences the circadian clock!
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Manchester Centre for Biological Timing @biologicaltimemcr.bsky.social · 11/08/2025
New preprint from our CfBT! Congratulation to Jafar, who defended his thesis back in May! doi.org/10.1101/2025...
doi.org
The club cell circadian clock regulates temporal patterns in leukocyte trafficking in chronic allergic airways disease
Rationale: Asthma displays temporally variable symptoms which worsen overnight, corresponding with a nocturnal increase in airway eosinophils. The molecular clock within the club cell of the bronchial...
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Manchester Centre for Biological Timing @biologicaltimemcr.bsky.social · 11/08/2025
New paper from our CfBT! Congratulations to Jess Treeby, second year PhD student! www.nature.com/articles/s41...
nature.com
Guanine is an inhibitor of c-jun terminal kinases - Scientific Reports
Scientific Reports - Guanine is an inhibitor of c-jun terminal kinases
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Manchester Centre for Biological Timing @biologicaltimemcr.bsky.social · 12/06/2025
New exciting preprint from our CfBT and associates! Guanine is an inhibitor of c-Jun terminal kinases www.researchsquare.com/article/rs-6...
researchsquare.com
Guanine is an inhibitor of c-Jun terminal kinases
The toxicity of purine bases adenine and guanine is mostly recognized when associated with inborn errors of purine metabolism such as Lesch-Nyhan syndrome, and metabolic diseases with a lifestyle comp...
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Manchester Centre for Biological Timing @biologicaltimemcr.bsky.social · 12/06/2025
New exciting preprint from our CfBT and associates! The 18S rRNA methyltransferase, BUD23, is required for appropriate lipid and mitochondrial metabolism www.biorxiv.org/content/10.1...
biorxiv.org
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Manchester Centre for Biological Timing @biologicaltimemcr.bsky.social · 09/05/2025
Upcoming: Joanna Chiu's Seminar at the CfBT! Date: Tuesday, 13 May 2025 Time: 13:00-14:00 Venue: Michael Smith Lecture Theatre Title: “Metabolic and environmental regulation of circadian biology”.
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Manchester Centre for Biological Timing @biologicaltimemcr.bsky.social · 16/04/2025
CfBT in the News! www.bbc.co.uk/news/article...
bbc.co.uk
Afternoon inhaler puff could improve asthma symptoms - study finds
Researchers in Manchester say coordinating asthma medication to the body clock could bring benefits.
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Manchester Centre for Biological Timing @biologicaltimemcr.bsky.social · 16/04/2025
Latest from our CfBT! The impact of dosage timing for inhaled corticosteroids in asthma: a randomised three-way crossover trial thorax.bmj.com/content/earl...
thorax.bmj.com
The impact of dosage timing for inhaled corticosteroids in asthma: a randomised three-way crossover trial
Background Asthma demonstrates a robust daily rhythm, with airflow obstruction and airway inflammation peaking overnight. Aligning the timing of drug administration with rhythms in disease (chronother...
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Reposted by Manchester Centre for Biological Timing
D’Agostino Lab @dagostinolab.bsky.social · 07/04/2025
Our latest study @science.org #Immunology on perception of #hunger and #immunity. #BrainBody #Melanocortin #AgRP #POMC neurons. #Brain-liver axis. Permissive action of #stress #hormones. @ukri.org @fbmh-uom.bsky.social www.science.org/doi/10.1126/...
science.org
Brain sensing of metabolic state regulates circulating monocytes
Brain-initiated hunger signals control circulating monocyte dynamics.
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Manchester Centre for Biological Timing @biologicaltimemcr.bsky.social · 24/03/2025
3 of us representing the Centre at the EuroAgeNet conference in Liverpool!
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Manchester Centre for Biological Timing @biologicaltimemcr.bsky.social · 21/03/2025
CfBT's recommended reading: www.nature.com/articles/s42...
nature.com
The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research - Nature Metabolism
This broad group of authors summarizes the impact of circadian factors on metabolic biology and offers recommendations on how to account for and report biological, environmental and experimental facto...
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Manchester Centre for Biological Timing @biologicaltimemcr.bsky.social · 19/03/2025
Don't miss the Spring Clock Club in Coventry on March 20-21! www.bioclocks.uk/event-detail...
bioclocks.uk
Spring Clock Club 2025 Coventry | Bioclocks Uk
Join us for our bi-annual Clock Club gathering! The main event and talks will be taking place on Friday the 21st of March. We also have several enriching workshops running on Thursday the 20th of Mar...
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Luísa Tupinambá Jabbur @jabbur.bsky.social · 19/03/2025
very excited for Clock Club @bioclocksuk.bsky.social this week, and especially for @williams-steph.bsky.social talk on flowering and winter! ❄️🌼
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Manchester Centre for Biological Timing @biologicaltimemcr.bsky.social · 11/03/2025
More details on our new Bicentenary PhD Student­ships and Fellow­ships: www.bmh.manchester.ac.uk/study/resear...
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Manchester Centre for Biological Timing @biologicaltimemcr.bsky.social · 11/03/2025
Launch of CfBT's Recommended Readings, highlighting papers of interest for chronobiologists and beyond! Today's choice, a review: Non-Image-Forming Functions of Intrinsically Photosensitive Retinal Ganglion Cells doi.org/10.1146/annu...
doi.org
Non-Image-Forming Functions of Intrinsically Photosensitive Retinal Ganglion Cells | Annual Reviews
Life on this planet is heavily influenced by light, the most critical external environmental factor. Mammals perceive environmental light mainly through three types of photoreceptors in the retina—rod...
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Manchester Centre for Biological Timing @biologicaltimemcr.bsky.social · 05/03/2025
For its 200th anniversary, the University of Manchester is offering competitive PhD Studentships and Early Career Research Fellowships. The CfBT is keen to support applications in biological timing research as a strategic priority. www.bmh.manchester.ac.uk/study/resear...
bmh.manchester.ac.uk
Bicentenary PhD Studentships and Fellowships | Biology, Medicine and Health | University of Manchester
Find out more about the Bicentenary PhD Studentships and Fellowships for researchers with an interest in discovery and innovation in bioscience, biomedical and health research.
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Manchester Centre for Biological Timing @biologicaltimemcr.bsky.social · 27/02/2025
The Meth Lab is featured in @bioclocksuk.bsky.social, www.bioclocks.uk/research/die...
bioclocks.uk
What you don’t eat could be affecting your circadian behaviour | Bioclocks Uk
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Manchester Centre for Biological Timing @biologicaltimemcr.bsky.social · 25/02/2025
Feeling blue? doi.org/10.1093/slee...
doi.org
Blue Light Influences Negative Thoughts of Self
Abstract. Darkness is equated with sadness. This study explored how light that differentially impacts non-visual photoreception (blue-enriched vs blue-depl
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Manchester Centre for Biological Timing @biologicaltimemcr.bsky.social · 25/02/2025
On the path to a better NHS? The Trump effect? Conspicuous lack of The Three Keywords: www.england.nhs.uk/long-read/20...
england.nhs.uk
NHS England » 2025/26 priorities and operational planning guidance
Foreword from the NHS Chief Executive Our 76-year history is one of progress and transformation – as society, technology and medicine have changed, so has our health service. But the NHS currently fac...
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Manchester Centre for Biological Timing @biologicaltimemcr.bsky.social · 25/02/2025
Stuck in time: The slow march of circadian medicine and how to speed it up onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
<em>Journal of Sleep Research</em> | ESRS Journal | Wiley Online Library
While there is considerable enthusiasm for the translational and clinical applications of chronobiology, their actual implementation is not progressing as rapidly as might be expected. Here we discus...
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Social Responsibility at The University of Manchester @socialresponuom.bsky.social · 24/02/2025
We are excited to announce that we have retained our top 10 global position in the QS World University Sustainability Rankings🎊 Read more: buff.ly/40ZQt1z @official-uom.bsky.social #socialresponsibility #universityofmanchester #UoM #MakingaDifference #Sustainability
buff.ly
Manchester retains top 10 global position QS World University Sustainability Rankings > Social Responsibility
The University of Manchester has reaffirmed its status as a global leader in sustainability by retaining its position in the top 10 worldwide in the 2025 QS World University Sustainability Rankings.…
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Manchester Centre for Biological Timing @biologicaltimemcr.bsky.social · 10/01/2025
We'll be welcoming Gen Kurosawa from RIKEN to our centre of Biological Timing in February to deliver a talk about his latest work on hibernation nature.com/articles/s44....
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Manchester Centre for Biological Timing @biologicaltimemcr.bsky.social · 09/01/2025
Coffee in the morning associated with lower mortality. Does that weaken your New Year's resolution to drink less coffee? Coffee drinking timing and mortality in US adults academic.oup.com/eurheartj/ar...
academic.oup.com
Coffee drinking timing and mortality in US adults
AbstractBackground and Aims. To identify the patterns of coffee drinking timing in the US population and evaluate their associations with all-cause and cau
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Manchester Centre for Biological Timing @biologicaltimemcr.bsky.social · 27/12/2024
Wishing you a happy holiday season and a peaceful New Year!
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sleeprhythm.bsky.social @sleeprhythm.bsky.social · 28/11/2024
Let's get "translating" chronobiology! A lot of data and some thoughts on Daylight Saving Time and school start times. www.tandfonline.com/doi/full/10....
tandfonline.com
Assessing evidence in translational chronobiology: The cases of Daylight Saving Time and road safety, and of school start times and sleep duration
One of the main challenges in translating chronobiology research into clinical practice is represented by differences in how basic scientists and clinicians evaluate evidence. The workshop “Assessi...
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Reposted by Manchester Centre for Biological Timing
BioClocks UK @bioclocksuk.bsky.social · 16/12/2024
Translating research into impact is no easy feat. In 2023 scientists from teams including @sleeprhythm.bsky.social assessed evidence and produced conclusions about two chronobiology hot topics - how did they do it and could you do the same? www.bioclocks.uk/research/les... #chronobiology #DST 🧪
bioclocks.uk
Lessons from a translational chronobiology workshop | Bioclocks Uk
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