iiinova — where your digital self keeps evolving

Biljana Ermanoska @biljanaermanoska.bsky.social · 05/03/2026

Checking in from the Drosophila Research Conference in Chicago #Dros2026, starting the day with some beautiful images.

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Biljana Ermanoska @biljanaermanoska.bsky.social · 09/12/2025

If you are in Philly and #CellBio2025, and want to hear more on "Cross-species dissection of αII-spectrin function in neurons", stop by today at Board No. 235/P1361 during the poster session.

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Biljana Ermanoska @biljanaermanoska.bsky.social · 17/11/2025

Our paper is now part of the newest Cellular Neurobiology collection @jcb.org, check it out if you haven't yet. 🔬📖

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Reposted by Biljana Ermanoska

CellMech2025 @cellmech2025.bsky.social · 23/09/2025

😱 AHHHH!!! 1 week left for #cellmech2025 !!!! Do you have everything ready to come to Leuven?? Check our programme here 👉 buff.ly/XqP8rmF If you present your work, check this 👉 buff.ly/wYloavk

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Reposted by Biljana Ermanoska

Christophe 🔬 Leterrier @christlet.bsky.social · 17/09/2025

Our new preprint is up! This is the main postdoc work of @wiesner-t.bsky.social focusing on exocytosis along the axon shaft and its regulation by the sub membrane actin-spectrin scaffold: www.biorxiv.org/content/10.1... Read the thread below for a summary of our findings 🧵1/11

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Reposted by Biljana Ermanoska

Shashank Shekhar lab @sshekhr.bsky.social · 29/08/2025

📢📢Hiring 2 Research Assistants & 2 Postdocs at Emory University in Atlanta to study cytoskeletal biophysics/biochemistry. Please RT. RAs: great for recent bachelor's/master's in Physics/Bio/Chem/Biochem. Email CV and interests to shekhar@emory.edu. More info: www.shekharlab.org

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Reposted by Biljana Ermanoska

Andreas Prokop @poppi62.bsky.social · 13/07/2025

My first thought when reading the title was integrins, and it was nice to see that authors established that link bringing together previous and new stuff.

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Reposted by Biljana Ermanoska

Journal of Cell Biology @jcb.org · 14/07/2025

@biljanaermanoska.bsky.social, Baets, and @rodallab.bsky.social show that a presynaptic actomyosin core coordinates with Integrin receptors to maintain neuron-muscle mechanical continuity at #Drosophila neuromuscular junctions. rupress.org/jcb/article/...

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Reposted by Biljana Ermanoska

Rockefeller University Press @rupress.org · 14/07/2025

In @jcb.org, @biljanaermanoska.bsky.social, Baets, and @rodallab.bsky.social show that a presynaptic actomyosin core coordinates with Integrin receptors to maintain neuron-muscle mechanical continuity at #Drosophila neuromuscular junctions. rupress.org/jcb/article/...

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Biljana Ermanoska @biljanaermanoska.bsky.social · 12/07/2025

5/5 Together, our findings reveal a mechanically sensitive actin–NMII–integrin system at the NMJ—capable of adapting to tension changes to preserve synaptic structure and function.

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Biljana Ermanoska @biljanaermanoska.bsky.social · 12/07/2025

4/5 To probe mechanical sensitivity, we used axon severing and stretching. We found that presynaptic actomyosin and integrin organization respond dynamically to loss and gain of tension.

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Biljana Ermanoska @biljanaermanoska.bsky.social · 12/07/2025

3/5 Interestingly, depleting neuronal NMII also disrupted postsynaptic NMII organization, pointing to transsynaptic coordination of actomyosin networks. At the same time, integrin receptors were reduced on both sides of the synapse, indicating compromised neuron–muscle adhesion.

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Biljana Ermanoska @biljanaermanoska.bsky.social · 12/07/2025

2/5 This linear actin assembly is decorated with nonmuscle myosin II (NMII) and becomes disorganized when NMII is depleted or its activity disrupted—highlighting its reliance on NMII for structural integrity.

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Biljana Ermanoska @biljanaermanoska.bsky.social · 12/07/2025

Honored that our work with @rodallab.bsky.social and Jonathan Beats has found its final home @jcb.org. We identify a presynaptic actin core at the Drosophila NMJ—a long-lived, NMII-dependent structure that may help synapses withstand mechanical stress. 🧵 1/5

rupress.org

Nonmuscle myosin II regulates presynaptic actin and neuronal mechanobiology in Drosophila

Neurons and muscles must maintain structural contact despite mechanical strain. Ermanoska et al. identify a presynaptic actomyosin core at Drosophila neuro

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Biljana Ermanoska @biljanaermanoska.bsky.social · 12/07/2025

Thank you, Christophe, for your kind words and for monitoring our work to the finales! We are honored to have it published @jcb.org!

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