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Mark Davison

@bigexperiment.bsky.social
2.1K followers 6.7K following 117 posts

Tech CEO, science podcaster, investor, runner, cyclist. Solving temperature control (www.grantinstruments.com). Interviewing biotech founders on "The Big Experiment" thebigexperiment.buzzsprout.com/231…

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Mark Davison @bigexperiment.bsky.social · 13/04/2025
Three million child deaths per year linked to antibiotic resistance. Major bacterial threats will re-emerge for all of us, unless we control the use of antibiotics, and discover new ones. 🧪
bbc.com
Three million child deaths linked to drug resistance
Children in Africa and South East Asia are most at risk from antibiotics medicines no longer working, a study suggests.
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Mark Davison @bigexperiment.bsky.social · 25/03/2025
Pathogens to watch. 🧪
bbc.com
Priority pathogens: UK draws up new disease-threat watch list
Some are viruses with global pandemic potential - like Covid - others infectious illnesses with no treatments.
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Mark Davison @bigexperiment.bsky.social · 10/03/2025
Lab-grown food that tastes like real meat could be transformational. It can improve animal welfare (no death), climate change (uses less water, creates less GHGs), biodiversity (less farmland = more nature), hygiene (eg. no bird flu), and more. Interesting to see how this goes. 🧪
bbc.co.uk
Lab-grown food could be sold in UK in two years
The Food Standards Agency (FSA) is looking at how it can speed up the approval process for lab-grown foods.
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Mark Davison @bigexperiment.bsky.social · 04/03/2025
You're right. Deleted. Seemed like a good idea in my head but was in fact dumb.
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Mark Davison @bigexperiment.bsky.social · 27/02/2025
Happy to organise a demo for your lab (by Teams or on-site).
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Mark Davison @bigexperiment.bsky.social · 26/02/2025
That's the theory. Each protocol is different but this device gives them the best chance.
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Mark Davison @bigexperiment.bsky.social · 26/02/2025
Having a bad day? My lucky Ace of Spades banana can help. Scientifically endorsed by Lemmy's ghost. 🧪
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Mark Davison @bigexperiment.bsky.social · 26/02/2025
Ice makes your organoids go bang in poor thawing protocols. Accept low yields and variable results, or fix the problem with electrically controlled freeze-thaw. Same great result every time. Small and cost-effective. Every stem cell or organoids lab needs one. 🧪
grantinstruments.com
Controlled Rate Freeze Thaw - CRFT
The CRFT is a programmable freezing and thawing system that allows you ultimate control of cryopreservation research protocols.
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Mark Davison @bigexperiment.bsky.social · 26/02/2025
Sweetener aspartame aggravates atherosclerosis. 🧪
cell.com
Sweetener aspartame aggravates atherosclerosis through insulin-triggered inflammation
Wu et al. provide new insights into how aspartame consumption exacerbates atherosclerosis through an insulin-dependent mechanism. Aspartame-triggered high insulin levels upregulate the endothelial mem...
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Mark Davison @bigexperiment.bsky.social · 20/02/2025
Meet the AI Microbiologist 🧪
bbc.co.uk
AI cracks superbug problem in two days that took scientists years
The lead researcher has told the BBC he was so astounded he assumed his computer had been hacked.
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Mark Davison @bigexperiment.bsky.social · 19/02/2025
Civilization is tissue-thin. Dead ones were great once, too. Read Jared Diamond's "Collapse" for an analysis of how it happens. Or Shelley's "Ozymandias" for a more poetic warning.🧪
theguardian.com
There are many ways Trump could trigger a global collapse. Here’s how to survive if that happens | George Monbiot
It could be wildfires, a pandemic or a financial crisis. The super-rich will flee to their bunkers – the rest of us will have to fend for ourselves, writes columnist George Monbiot
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Mark Davison @bigexperiment.bsky.social · 18/02/2025
Very interesting progress on migraines. Article is behind a paywall but there's enough visible to get the gist. 🧪
nature.com
Migraine is more than a headache — a radical rethink offers hope to one billion people
Drugs that can prevent or relieve migraine attacks are only effective for some people. Research is starting to untangle the reasons why.
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Mark Davison @bigexperiment.bsky.social · 17/02/2025
Keeping It Up: The Story of Viagra. Fascinating BBC documentary, and great insight into big pharma's workings. 🧪
bbc.co.uk
Storyville - Keeping It Up: The Story of Viagra
Twenty-five years ago, Viagra kick-started the second sexual revolution and a controversy unlike any drug before it. From Wales to New York, this is the big story of the little blue pill.
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Mark Davison @bigexperiment.bsky.social · 17/02/2025
Intelligent life may evolve more easily than we thought. Interesting read. 🧪
science.org
A reassessment of the “hard-steps” model for the evolution of intelligent life
Humans—and analogous life beyond Earth—may represent the probable outcome of biological and planetary coevolution.
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Mark Davison @bigexperiment.bsky.social · 17/02/2025
Pope Francis has a "polymicrobial infection". He's wise enough to know that hopes-and-prayers don't replace science (strong antibiotics). He's also pro-vax. 🧪
bbc.co.uk
Pope Francis's health a 'complex clinical situation', Vatican says
The pontiff will remain in hospital for as long as necessary, the Vatican has said.
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Mark Davison @bigexperiment.bsky.social · 14/02/2025
"A male’s ability to subvert his rivals is central to his reproductive success" Fruit fly world is like high school. 🧪
dlvr.it
Male-male interactions shape mate selection in Drosophila
Male-male competition strongly influences mate selection in Drosophila, with males performing wing flicks to repel their rivals and jam a female’s perception of other potential mates. Recruitment of p...
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Mark Davison @bigexperiment.bsky.social · 13/02/2025
Potential game changer test. Prognosis for pancreatic is usually terrible because it is often stage 4 when discovered. 🧪
nature.com
Cheap blood test detects pancreatic cancer before it spreads
The deadly cancer is often not found until it has spread to other parts of the body.
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Mark Davison @bigexperiment.bsky.social · 12/02/2025
Indeed. Also "I was born with a plastic spoon in my brain" is (almost) the opening line from verse 2 of "Substitute" by The Who.
google.co.uk
The Who - Substitute
The Who - Live At The Fillmore East 1968 out now! Check it out: https://lnk.to/TheWhoFillmoreEast Explore more music from The Who: https://lnk.to/TheWhoBestOf Follow us: https://www.instagram.com/officialthewho/ https://www.facebook.com/thewho/ https://twitter.com/TheWho #TheWho Music video by The Who performing Substitute. (C) 1988 Polydor Ltd. (UK)
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Mark Davison @bigexperiment.bsky.social · 12/02/2025
Microplastics: 10g isolated per donated human brain. That's two teaspoons. Imagine that's not great for microvasculature....🧪
nature.com
Your brain is full of microplastics: are they harming you?
Plastics have infiltrated every recess of the planet, including your lungs, kidneys and other sensitive organs. Scientists are scrambling to understand their effects on health.
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Mark Davison @bigexperiment.bsky.social · 11/02/2025
Study implies that basic life abounds in the Universe. So why can't we find aliens? See Fermi Paradox for possible reasons 🧪 en.m.wikipedia.org/wiki/Fermi_p...
en.m.wikipedia.org
Fermi paradox - Wikipedia
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Mark Davison @bigexperiment.bsky.social · 11/02/2025
Tricky, but the major generalist journals (Nature, Science, Cell, PNAS etc) often have a News and Views section on their websites which summarises articles of wider interest, and/or email newsletters. The BBC is also a good source for popular but accurate science summaries.
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Mark Davison @bigexperiment.bsky.social · 11/02/2025
Physical activity helps protect against age-related decline in physical performance. Use it or lose it. 🧪
cell.com
Impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca2+ handling across the adult lifespan in men
Cefis et al. show that mitochondrial respiration and ROS production are not affected during healthy muscle aging but identify altered mitochondrial calcium handling as a potential key driving mechanis...
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Mark Davison @bigexperiment.bsky.social · 10/02/2025
And cancer. Worth a listen. open.spotify.com/episode/7G2o...
open.spotify.com
Therapeutic brain-computer-interfaces for glioblastoma, with Dr Elise Jenkins
The Big Experiment · Episode
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Mark Davison @bigexperiment.bsky.social · 10/02/2025
Europe explodes into space as earth's core changes shape. Visual proof below. 🧪 UK still oddly cold.
bbc.co.uk
Earth's inner core may have changed shape, say scientists
The findings shed light on a deeply mysterious part of Earth that is key to life on our planet.
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Mark Davison @bigexperiment.bsky.social · 10/02/2025
A great listen for medical device engineers, cancer biologists, oncologists, and anyone affected by this horrible disease 🧪
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Mark Davison @bigexperiment.bsky.social · 10/02/2025
Killing glioblastoma (brain cancer) with a brain-computer- interface. Hear my podcast guest discuss: 🩺 Tiny sensor fits inside a skull drill hole 🚦 Detecting differences in cancer brain signal 💡 Sending data through skin, without wires ⚡ Power without a battery 🔦 "Tuning out" cancer growth
open.spotify.com
Therapeutic brain-computer-interfaces for glioblastoma, with Dr Elise Jenkins
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Mark Davison @bigexperiment.bsky.social · 10/02/2025
Brain cancer, and how to fight it with amazing tech. Great podcast episode! 🧪 open.spotify.com/episode/7G2o...
open.spotify.com
Therapeutic brain-computer-interfaces for glioblastoma, with Dr Elise Jenkins
The Big Experiment · Episode
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Mark Davison @bigexperiment.bsky.social · 08/02/2025
That's awful. Let's hope we never see those times again.
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Mark Davison @bigexperiment.bsky.social · 08/02/2025
One out of two assertions was correct, I was being charitable 😁
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Mark Davison @bigexperiment.bsky.social · 08/02/2025
Definitely. Flu floors you and then bacteria stick the boot in. As neatly summarised by Dr Fauci in 2008...🧪
pmc.ncbi.nlm.nih.gov
Predominant Role of Bacterial Pneumonia as a Cause of Death in Pandemic Influenza: Implications for Pandemic Influenza Preparedness
Despite the availability of published data on 4 pandemics that have occurred over the past 120 years, there is little modern information on the causes of death associated with influenza pandemics. We ...
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Mark Davison @bigexperiment.bsky.social · 08/02/2025
Flu infects. Just doing its job. May feel like a heavy cold, or it may channel 1918 and kill you one day, who knows. #CDC is a vital defense.🧪
npr.org
The 1918 Flu Pandemic Was Brutal, Killing More Than 50 Million People Worldwide
"We had no ICUs at that time. We had no antivirals, had no vaccines for flu. We had no idea that the flu was even a virus at that time," one scholar said. But social distancing helped then too.
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Mark Davison @bigexperiment.bsky.social · 07/02/2025
It ain't about how hard you can hit, it's about how hard you can GET hit and still keep swimming forward 😁🥊
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Mark Davison @bigexperiment.bsky.social · 07/02/2025
We are entering a new, man-made biological universe. 🧪
cell.com
A roadmap toward the synthesis of life
This perspective offers a cross-disciplinary roadmap toward synthetic life that does not shy away from technical and non-technical challenges, ethical concerns, and provocative implications, embracing...
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Mark Davison @bigexperiment.bsky.social · 07/02/2025
Moves like a butterfly, stings like a shrimp...🧪
nature.com
Mantis shrimp have the world’s fastest punch — here’s how their limbs survive
Insights from probing the shock-absorbing layer within the crustacean’s club-like claw could inspire the design of tough new materials.
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Mark Davison @bigexperiment.bsky.social · 06/02/2025
Don't sniff at this idea. Harmless microbes as intranasal drug couriers to your brain. 🧪
cell.com
Engineered commensals for targeted nose-to-brain drug delivery
Shen et al. investigate the use of Lactobacillus plantarum, a commensal bacterial strain, as a chassis for targeting the olfactory mucosa to facilitate precise nose-to-brain delivery of therapeutic mo...
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Mark Davison @bigexperiment.bsky.social · 05/02/2025
Basically lab grown blood will eventually work in many medical applications. A few years not decades away.
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Mark Davison @bigexperiment.bsky.social · 05/02/2025
You get one free article read. I'm not a subscriber to this one.
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Mark Davison @bigexperiment.bsky.social · 05/02/2025
Lab-grown blood is closer than you think 🧪
newyorker.com
The Long Quest for Artificial Blood
One of the most valuable substances in the world has never been replicated. Are we close?
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Mark Davison @bigexperiment.bsky.social · 04/02/2025
Bacteria can kill you or cure you. Here are some positive uses. 🧪
nature.com
Microbes in space: how bacteria could help sustain long-distance space travel
So far, microorganisms have been research subjects or contaminants on space stations, but could they assist longer missions?
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Mark Davison @bigexperiment.bsky.social · 04/02/2025
One more time for RFK. Vaccines save lives. Period. End of story. 🧪
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Mark Davison @bigexperiment.bsky.social · 03/02/2025
Grant Instruments is making a customised precision water bath, with 200 litre capacity, for a top UK university. For reference, that's the volume of a UK wheelie bin, as modeled by the charity runner below. DM me if you need unusual temp control solutions in your lab 🧪
Sunderland bin man (refuse collector) Deano Franciosy gets ready to take on 26.2 miles London Marathon with wheelie bin strapped to his back
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Mark Davison @bigexperiment.bsky.social · 01/02/2025
From 2007, but relevant. Proof that vaccines save lives and prevent suffering. You are here partly because your forebears didn't die in childhood of an infectious disease. 🧪
jamanetwork.com
Historical Comparisons of Morbidity and Mortality for Vaccine-Preventable Diseases in the United States
Context National vaccine recommendations in the United States target an increasing number of vaccine-preventable diseases for reduction, elimination, or eradication.Objective To compare morbidity and ...
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Mark Davison @bigexperiment.bsky.social · 01/02/2025
Benign climate change is a myth. There are just various bad possibilities.🧪
bbc.com
Could the UK actually get colder with global warming?
Some scientists fear the risk of a collapse to warm Atlantic currents has not been taken seriously.
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Mark Davison @bigexperiment.bsky.social · 31/01/2025
Interesting. This technique gives a "shuffle" function to human genome studies, at unprecedented scale. Should generate new insights into gene function, and why we have so much apparent "filler" DNA. 🧪
science.org
Randomizing the human genome by engineering recombination between repeat elements
We lack tools to edit DNA sequences at scales necessary to study 99% of the human genome that is noncoding. To address this gap, we applied CRISPR prime editing to insert recombination handles into re...
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Mark Davison @bigexperiment.bsky.social · 30/01/2025
Promising advance in bowel cancer prediction 🧪
news.cancerresearchuk.org
DNA testing predicts bowel cancer risk in people with IBD - Cancer Research UK - Cancer News
A DNA testing method is 90% accurate at predicting bowel cancer risk in high-risk people with IBD, according to a study by our scientists.
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Mark Davison @bigexperiment.bsky.social · 29/01/2025
Very cool if this stem-cell-derived heart patch works in wider trials. Lab-grown tissue has endless potential in medicine (and food). 🧪
bbc.com
Scientists trial implant to patch up the heart
The technology could give patients with advanced heart failure new hope, based on early trial results.
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Mark Davison @bigexperiment.bsky.social · 29/01/2025
The human genome encodes potentially thousands of tiny proteins that were previously overlooked. The search is on to find out what they do. 🧪
nature.com
‘Dark proteins’ hiding in our cells could hold clues to cancer and other diseases
The human genome encodes potentially thousands of tiny proteins that were previously overlooked. The search is on to find out what they do.
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Mark Davison @bigexperiment.bsky.social · 28/01/2025
For pathogens, it's not personal. It's strictly business. As a microbiologist, I admire and fear them in equal measure. 🧪
gavi.org
Which infectious disease is likely to be the biggest emerging problem in 2025?
Three existing human infections are causing the greatest concern, but H5N1 bird flu is also worrying human and animal health experts.
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Mark Davison @bigexperiment.bsky.social · 28/01/2025
Not if, but when, IMO 🧪
nature.com
Will bird flu spark a human pandemic? Scientists say the risk is rising
H5N1 is adapting to new mammalian hosts, raising the possibility of the virus spreading between humans.
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Mark Davison @bigexperiment.bsky.social · 28/01/2025
Useful review below of hepatic #organoids and their applications 🧪 If you freeze and thaw organoids, DM me to improve your yield and save time and money.
stemcellres.biomedcentral.com
Advances in liver organoids: replicating hepatic complexity for toxicity assessment and disease modeling - Stem Cell Research & Therapy
The lack of in vivo accurate human liver models hinders the investigation of liver-related diseases, injuries, and drug-related toxicity, posing challenges for both basic research and clinical applica...
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