Telomere oxidation sensitizes cancer cells to low-dose ATR inhibition by producing replication stress through RPA exhaustion, CDC7-mediated dormant-origin firing, and early entry into mitosis with unr...

The industry can’t continue to sit idly by while Robert F. Kennedy Jr. guts the nation’s public health agencies.

Szmyd et al. show that DNA repair pathways impact whether cells with DNA lesions arrest in mitosis. The formation of homologous recombination-driven double Holliday junctions elicits mitotic cell deat...