AbstractRationale. Cardiac sarcoidosis is a granulomatous inflammatory disease that frequently progresses to irreversible myocardial fibrosis and lethal co

AbstractRationale. Yes-associated protein (YAP)-mediated fibroblast mechanoactivation is an important driver of fibrosis in idiopathic pulmonary fibrosis (

The American Journal of Respiratory and Critical Care Medicine thanks all the authors in this issue for submitting their stellar work to the Journal. As pa

Abstract. Acute exacerbations (AEs) occur both in patients with idiopathic pulmonary fibrosis (IPF) and those with non-IPF fibrotic interstitial lung disea

This issue's special section on interstitial lung disease (ILD) spans the translational spectrum of ILD research, encompassing clinical practice guidelines

In the past 2 decades, there have been no more dramatic developments in the world of cystic fibrosis (CF), or perhaps any respiratory disease, than the adv

AbstractRationale. Non-sputum biomarkers to monitor tuberculosis treatment and predict poor outcomes are lacking.Objectives. To evaluate host-blood transcr

AbstractRationale. While therapeutic advances have improved survival for patients with Group 1 pulmonary arterial hypertension (PAH), patients with Group 1

AbstractRationale. In acute respiratory distress syndrome (ARDS), extracorporeal membrane oxygenation (ECMO) without invasive mechanical ventilation (IMV)

AbstractRationale. Tidal recruitment/derecruitment (R/D) is a well-known mechanism of lung injury in acute respiratory distress syndrome (ARDS) patients, b

Abstract. Extracorporeal life support provides temporary cardiorespiratory support for patients with severe, potentially reversible cardiac and/or respirat

AbstractBackground. Acute hypoxemic and hypercapnic respiratory failure are among the most common reasons for ICU admission and need for invasive mechanica

AbstractRationale. The frequent exacerbator phenotype was previously defined using a threshold of ≥3 exacerbations per year in bronchiectasis. However, the

AbstractBackground. The progression from mild-to-moderate to severe asthma remains unclear. This study aimed to assess the risk of progression following th

AbstractRationale. Asthma is characterized by disruption of the thoracic airway mucosae and loss of microbial diversity. Spatial profiling of the mucosal t

Abstract. Mucus plugs have been previously recognized as an important pathological feature in asthma and chronic obstructive pulmonary disease (COPD), but

The exposome, reflecting the totality of an individual's exposures, is dynamic and exerts both short- and long-term effects on respiratory health and disea

Abstract. More than 400 million people have chronic obstructive pulmonary disease (COPD), with exacerbations representing a major health burden. Although t

AbstractRationale. The efficacy and safety of astegolimab, an anti-ST2 monoclonal antibody, was evaluated in participants with chronic obstructive pulmonar

AbstractRationale. Disease stability in chronic obstructive pulmonary disease (COPD) is a low disease activity state proposed as a treatment target.Objecti

AbstractRationale. Blood eosinophil count (BEC) is a biomarker indicating type 2 inflammation in patients with chronic obstructive pulmonary disease (COPD)

AbstractRationale. Clinical trials of severe asthma therapies often exclude or underrepresent key patient populations.Objectives. To evaluate the effective

Race is a social construct based on current or perceived physical appearance and ancestry. Ethnicity is another social construct based on cultural behavior

AbstractRationale. Non-sputum biomarkers to monitor tuberculosis treatment and predict poor outcomes are lacking.Objectives. To evaluate host-blood transcr

Poor adherence to continuous positive airway pressure (CPAP) hampers benefits to patients with obstructive sleep apnea (OSA),1 and adherence rates have rem

To the Editor:

Airway-occluding mucus plugs are associated with lung function decline and all-cause mortality in chronic obstructive pulmonary disease (COPD).1,2 While sm

From The Archives: Dr. John Fleetham chats with Dr. Barbara Jones about her ATS guideline, "Diagnosis and Management of Community-acquired Pneumonia. An Official American Thoracic Society Clinical ...

To the Editor:

To the Editor:

Scientists have found how phages, viruses that infect bacteria, orchestrate an explosion of protein modifications inside host cells that helps them

Rates are now the highest they've been in nearly 50 years among veteran coal miners. Mining experts blame toxic silica dust, now more common in mines.

Dr. Mohleen Kang interviews Dr. Stephanie Robinson and Dr. Marilyn Moy about their article, “Pulmonary Rehabilitation Is Associated with Increased 1-Year Survival in Stable Chronic Obstructive Pulm...