Bacteria and archaea encode hundreds of antiviral defense systems, some with homologs found in eukaryotic innate immunity. GHL ATPases like plant MORCs and prokaryotic Tiamat defend against viruses an...

The conservation of immune systems from prokaryotes to eukaryotes can guide discovery of immunity genes across the tree of life. Most studies to date have focused on metazoan systems, while the extent...

Chromatin is the complex of DNA, RNA and protein that is found making up the chromosomes in eukaryotic cells. Chromatin is essential for proper genome function and is involved in chromosome segregati…

Bacteria defend themselves from viral predation using diverse immune systems, many of which sense and target foreign DNA for degradation. Defense-associated reverse transcriptase (DRT) systems provide...

Do you remember your oldest memory? Jason Shepherd clearly recalls a childhood filled with questioning the world around him, which naturally lead to a life of scientific discovery. As a Neurobiologist...

Here, we present a novel approach to study packaging and mobilisation of bacterial DNA in complex microbial communities, such as the human gut microbiome, by viral or virus-like capsids. Transducing b...