Mapping DNA variants that modulate mortality using a starting population of 6,438 young mice defined 29 distinct loci that influence lifespan and mortality with divergent age-...

In a Phase 1 clinical study, researchers led by EPFL and their partners report that a new liver- and gut-targeted oral drug can safely lower triglycerides and other blood lipids.

Nature Metabolism, Published online: 24 September 2025; doi:10.1038/s42255-025-01360-4The authors highlight inconsistencies and divergencies in the literature reporting data on indirect calorimetry for studies on whole-body energy homeostasis, and propose harmonization of standards to facilitate data comparison and interpretation across different datasets.

The authors highlight inconsistencies and divergencies in the literature reporting data on indirect calorimetry for studies on whole-body energy homeostasis, and propose harmonization of standards to facilitate data comparison and interpretation across different datasets.

Using a zebrafish-based screen, Civiletto and colleagues identify the herb-derived metabolites thymol and carvacrol as activators of autophagy and mitophagy, demonstrating their therapeutic potential in C. elegans and mouse models.

An international team led by EPFL has discovered a powerful anti-aging pathway in roundworms, revealing how boosting the cell’s lysosomes can help clear waste and promote healthy aging. The findings o...

Longevity has been an underfunded area of biotech research but that is changing thanks to an unlikely source: Saudi Arabia.

EPFL scientists have uncovered how a gut bacterium, Clostridium scindens, aids in healing intestinal injuries by restoring bile acid balance. Their findings could pave the way for new treatments for u...

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The accumulation of ceramides and related metabolites has emerged as a pivotal mechanism contributing to the onset of age-related diseases. However, small molecule inhibitors targeting the ceramide de...

Andrea Ablasser, Johan Auwerx, Gioele La Manno and Matthias Lutolf, four professors at EPFL’s School of Life Sciences, have been included in the prestigious list of most Highly Cited Researchers in 20...