Nature Metabolism, Published online: 14 May 2026; doi:10.1038/s42255-026-01537-5Whole-blood NAD+ levels are found to remain remarkably stable across age and lifestyle interventions in humans, challenging the use of blood NAD+ levels as a biomarker of ageing or lifestyle.

Nature Metabolism, Published online: 14 May 2026; doi:10.1038/s42255-026-01540-wLevels of NAD+ have been widely proposed to decline with age in humans, but whether this holds true in whole blood remains unclear. Using a robust approach across multiple cohorts, we show that whole-blood NAD+ levels remain stable across age and lifestyle interventions, challenging its suitability as a biomarker of ageing.

This Review summarizes existing data, as well as crucial knowledge gaps, emerging from clinical trials involving NAD+ precursor supplementation in humans.

The Scientific Council of the European Research Council welcomes the offer of substantial additional budget from the European Commission for the development of a new ERC funding instrument offering la...

Pathway analysis, originally developed for gene expression data, has been adapted for metabolomics. However, owing to the unique characteristics and constraints of metabolites compared with genes, pat...