Armand @armand.bsky.social · 15/02/2026most are probably safe as long as you get them from a good source and they only contain the stated drug product, but we simply can't know this without a lot more work 010
Armand @armand.bsky.social · 15/02/2026it is unbelievably hard to understand how safe a drug is, for most peptides anyone who tells you they are *definitely* safe is either lying to you or very confused 110
Armand @armand.bsky.social · 15/02/2026the two main culprits are cerebrolysin and cortexin do not inject these, i put at least 10% odds on their being another prion disease wave (eg mad cow) (or just direct amyloid seeding -> AD?) in the next two decades because of this 100
Armand @armand.bsky.social · 15/02/2026one of the problems with the new peptide craze is that people unfamiliar with how hard it is to actually understand drug biology treat risk monolithically when it is anything but this tweet inspired by my absolute horror of people injecting pig brain lysates into their body 120
Armand @armand.bsky.social · 22/06/2025the further their area of expertise is from my technical experience the harder it is for me to judge them from just a conversation it was not super obvious to me that this was true in the beginning tho! it's a form of Gell-Mann amnesia en.wikipedia.org/wiki/Gell-M...en.wikipedia.orgGell-Mann amnesia effect - Wikipedia 000
Armand @armand.bsky.social · 22/06/2025for example one thing I've learned is that for pure scientists, roughly in my sphere of knowledge, I am great at assessing them from just talking to them 100
Armand @armand.bsky.social · 22/06/2025one good way to do this is to formally measure you and your team's ability to predict who will be a great candidate to a) find your superpredictors and b) uncover the the heuristics underlying your team's models that lead to both good and bad predictions 110
Armand @armand.bsky.social · 22/06/2025in the longer run you should keep training your internal model and intuition for what makes someone great 100
Armand @armand.bsky.social · 22/06/2025if I feel unsure about someone we won't hire them unless at least one other person on the hiring team has high enough conviction to actively fight for them and we always pass if one person has high conviction they won't be a great fit and we can't resolve 100
Armand @armand.bsky.social · 22/06/2025examples of the latter include: work trials, extensive ref checks (we do 9 minimum for everyone above RA), back-channeling, and having a diverse recruiting team that you trust such that at least a few people will have high s/n for any given candidate 100
Armand @armand.bsky.social · 22/06/2025so if you think someone could be great but feel uncertain about them you should immediately either pass or figure out if there is some other metric by which you can judge them with high conviction 100
Armand @armand.bsky.social · 22/06/2025tough in the moment but so, so worth it in the long run, especially for early hires: a core nucleus of people who are 100% amazing makes all subsequent hiring so much easier 100
Armand @armand.bsky.social · 22/06/2025we've had multiple roles where we've taken this tradeoff which sometimes meant running an interview process for an entire year until we found the right person 100
Armand @armand.bsky.social · 22/06/2025it's essentially a form of sacrifice—trading off someone who could be great rn for someone who definitely will be great later on—which sounds easy from the outside but becomes a much harder decision to make in the trenches when you are trying to scale your co as fast as possible 100
Armand @armand.bsky.social · 22/06/2025in practice this cashes out to being ok with waiting longer than you want for the candidate that you 100% know is a rockstar rather than the one whom you think might be 100
Armand @armand.bsky.social · 22/06/2025the corollary of this is that you should pass on people who you think could be great but aren't sure about as fast as possible in order to get to the candidates that you *know* are great 100
Armand @armand.bsky.social · 22/06/2025one mistake early founders often make is that they think they should be able to accurately assess every single candidate in a recruiting process unfortunately the candidates where you have high s/n is somewhat stochastic, based on your experience so far 100
Reposted by ArmandMarco @mcognetta.bsky.social · 05/01/2025I squeaked over the 2k followers mark on the last day of 2024. Let's see how it goes in 2025! 161
Reposted by ArmandStephan Hacker @stephanhacker2.bsky.social · 30/12/2024Since yesterday, I have been able to add: @kamatsiddhesh.bsky.social @balynzaro.bsky.social @armand.bsky.social (Armand Cognetta) @xingyuliu9595.bsky.social @vincorine.bsky.social (Benjamin Horning) 082
Armand @armand.bsky.social · 12/12/2024wrote a little more here! writing.arman.do/p/how-to-ha...writing.arman.doHow to have ideasa framework for effective ideation 010
Armand @armand.bsky.social · 12/12/20248/ [bonus] take lots of showers this is my personal hack, to the point where if I’m feeling stuck in my life I’ll consciously make an effort to take more/longer showers. I rarely get out of the shower without an idea or two to write about, think about, or work on 100
Armand @armand.bsky.social · 12/12/2024...And the point is, to live everything. Live the questions now. Perhaps you will then gradually, without noticing it, live along some distant day into the answer." –Rainer Maria Rilke 100
Armand @armand.bsky.social · 12/12/2024"Be patient toward all that is unsolved in your heart and try to love the questions themselves, like locked rooms and like books that are now written in a very foreign tongue. Do not now seek the answers, which cannot be given you because you would not be able to live them... 100
Armand @armand.bsky.social · 12/12/2024...Not too rapidly seeking the safety of knowing or the safety of a legible question, but waiting for a more powerful and subtle question to arise from loose and open attention. This patience with confusion makes them good at surfacing new questions." –Henrik Karlsson 100
Armand @armand.bsky.social · 12/12/2024"One thing that sets these intensely creative individuals apart, as far as I can tell, is that when sitting with their thoughts they are uncommonly willing to linger in confusion. To be curious about that which confuses... 100
Armand @armand.bsky.social · 12/12/20247/ embrace uncertainty creativity loves uncertainty. notice when you become confused or are entertaining two conflicting viewpoints, and just allow yourself to sit in that tension. 100
Armand @armand.bsky.social · 12/12/2024"Without great solitude, no serious work is possible." –Pablo Picasso "All truly great thoughts are conceived by walking." –Friedrich Nietzsche "The secret to doing good research is always to be a little underemployed. You waste years by not being able to waste hours." –Amos Tversky 110
Armand @armand.bsky.social · 12/12/20246/ make space for ideation a certain amount of chaos is good for creativity but if your mind is too cluttered or distracted mind it will probably hurt more than it helps. give yourself solitude, let yourself become bored, allow your mind to wander. solvitur ambulando. 100
Armand @armand.bsky.social · 12/12/2024a few months at least read the history of the great ideas, learn the rules, then forget them and let them sink into your blood: www.goodreads.com/quotes/3242...goodreads.comA quote by Rainer Maria RilkeAh! but verses amount to so little when one writes them young. One ought to wait and gather sense and sweetness a whole life long, and a long life if pos... 100
Armand @armand.bsky.social · 12/12/20245/ develop your idea taste once you start generating lots of ideas most will probably be bad. the way to improve taste is just exposure. when you have ideas share them with friends or publicly. the mark of a good idea is that you only more obsessed with it after putting it through this process for 100
Armand @armand.bsky.social · 12/12/20244/ write down everything writing down ideas, no matter how bad, strengthens your background ideation program. it gives you a chance to build off older ideas that you might have forgotten. and its important for developing idea taste. "Your mind is for having ideas, not holding them." –David Allen 100
Armand @armand.bsky.social · 12/12/2024...You have to keep a dozen of your favorite problems constantly present in your mind, although by and large they will lay in a dormant state." –Richard Feynman 100
Armand @armand.bsky.social · 12/12/2024"My approach to problem-solving is to carry around a dozen interesting problems, and a dozen interesting solutions to unrelated problems, and eventually, I’ll be able to make connections. [...] 100
Armand @armand.bsky.social · 12/12/2024"If you only read the books that everyone else is reading, you can only think what everyone else is thinking." –Haruki Murakami 100
Armand @armand.bsky.social · 12/12/20243/ accrete interesting knowledge your ideas will only be as good as the knowledge you are exposed to. read widely, search for weird viewpoints and thought experiments, etc. treat your information diet like an athlete does training. 100
Armand @armand.bsky.social · 12/12/2024"Everything around you that you call life was made up by people that were no smarter than you and you can change it, you can influence it, you can build your own things that other people can use." –Steve Jobs 100
Armand @armand.bsky.social · 12/12/20242/ believe there is a perfect idea out there believe the world is malleable and that there is some more perfect idea out there which you just have to find. then you simply go looking for it. make it a habit to always be looking for this within your area of interest. 100
Armand @armand.bsky.social · 12/12/2024"The way to get startup ideas is not to try to think of startup ideas… The way to come up with good startup ideas is to take a step back. Instead of trying to make a conscious effort to think of startup ideas, turn your brain into the type that has startup ideas unconsciously." –Paul Graham 100
Armand @armand.bsky.social · 12/12/2024"The best way to have a good idea is to have lots of ideas." –Linus Pauling, Nobel Prize (2x) 121
Armand @armand.bsky.social · 12/12/2024every now and then i have a good idea. here's how I think about having them: 1/ have lots of ideas you have to train your mind to be an idea engine and the easiest way to do that is to just to start having a lot of them. 131
Armand @armand.bsky.social · 05/12/2024oh nvm she posted this on x too, I guess this is just normal now 🙁 000
Armand @armand.bsky.social · 05/12/2024although ofc you should also try to increase the signal you get in as many ways as possible! 000
Armand @armand.bsky.social · 05/12/2024also many of the amazing people you pass on may well be actual rockstars, but for whatever reason the signal they are sending and the signal you are receiving isn't good enough for you to get conviction on that in this particular case, and you just have to be ok with that 100
Armand @armand.bsky.social · 05/12/2024and there's a certain type of uncomfortable uncertainty that comes with recruiting because you have to make a very big and hard to reverse decision with not a ton of info, so there's unconscious pressure to extricate yourself from this situation quickly 100
Armand @armand.bsky.social · 05/12/2024basically just another form of abundance mindset, but hard to do because at a startup there's always a massive amount of pressure to fill any position and its easy to convince yourself that someone could be good enough 110
Armand @armand.bsky.social · 05/12/2024one of the hard lessons I've learned about recruiting is that you've gotta be ok with passing on lots of amazing candidates that you think could be rockstars to get to the (much more rare) candidates that you absolutely *know* are 110
Armand @armand.bsky.social · 05/12/2024relatedly have friend who thinks it’s super important to have hobbies that require the use of two hands. so you can’t causally doom scroll while doing them 100
Armand @armand.bsky.social · 05/12/2024*reopens bsky after a year* *people publicly advocating for murder on the tl* *homer.gif* 100
