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Alessandro Piccin

@apiccin.bsky.social
105 followers 207 following 19 posts

Neuroscientist @neurobordeaux.bsky.social | Neuromodulation and adaptive behaviour | Sonic correspondent at ImpattoSonoro | 🇮🇹🇸🇪🇫🇷🇪🇺

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Reposted by Alessandro Piccin
Jérémie Naudé @jeremie-n.cpesr.fr · 15/07/2026
Nouvel article avec @ecoutureau.bsky.social ☺️ www.pnas.org/doi/10.1073/... Quand une récompense n'arrive pas, comment le cerveau nous permet de savoir s'il s'agit d'une malchance… ou d'un changement des règles du jeu ? On a suivi la trace d'un neuromodulateur, la noradrénaline, pour comprendre :
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Alessandro Piccin @apiccin.bsky.social · 19/03/2026
Shoutout to Eric J. Kremer and @marina-igmm.bsky.social of @igmm-montpel.bsky.social for these CAV2 PRS constructs. You can find them here: plateau-igmm.pvm.cnrs.fr
plateau-igmm.pvm.cnrs.fr
PVM – Plateforme de Vectorologie de Montpellier | Plateau IGMM
This non-profit vector core was created in 2013 to provide CAV-2 vectors to our colleagues for fundamental and preclinical research.
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Alessandro Piccin @apiccin.bsky.social · 19/03/2026
Maybe now the OFC will be your favorite prefrontal region too!
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Alessandro Piccin @apiccin.bsky.social · 19/03/2026
Not sure what was translated, since the post is already in English, but yes - broader/plain-language way of referring to a positive RPE (previously non-reinforced action suddenly producing a reward)
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Alessandro Piccin @apiccin.bsky.social · 19/03/2026
Thanks Ben!
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Alessandro Piccin @apiccin.bsky.social · 18/03/2026
A real team effort alongside Hadrien Plat, @dryacinetensaouti.bsky.social, @mathieuwolff.bsky.social, Alain Marchand and @ecoutureau.bsky.social. Grateful to @neurobordeaux.bsky.social, @univbordeaux.bsky.social, @agencerecherche.bsky.social and @bbrfoundation.bsky.social for the support.
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Alessandro Piccin @apiccin.bsky.social · 18/03/2026
Very proud to share our most recent work, now out in @cp-cellreports.bsky.social 🎉🎉🎉 We show that brief noradrenergic signals in the orbitofrontal cortex, triggered by surprising rewards, support reversal learning and predict how quickly animals adapt. www.cell.com/cell-reports...
cell.com
Orbitofrontal noradrenaline acts as an early gate for reversal learning
Piccin et al. find that surprising rewards trigger brief orbitofrontal noradrenergic bursts whose magnitude predicts reversal learning speed. Targeted manipulation of noradrenergic neurons projecting ...
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Reposted by Alessandro Piccin
Shauna Parkes @shaunaparkes.bsky.social · 21/08/2025
New Dispatch in @currentbiology.bsky.social w/ @RobinPiquet & @dryacinetensaouti.bsky.social highlighting elegant work from the @iordanova.bsky.social lab that formally disentangles whether dopamine signals reward prediction errors or value. authors.elsevier.com/a/1ldGk3QW8S...
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Reposted by Alessandro Piccin
Shauna Parkes @shaunaparkes.bsky.social · 23/04/2025
As Chair of the Bordeaux Neurocampus Parity and Inclusion Committee, I’m pleased to share we’ve received generous CNRS funding to expand our inclusion efforts. Thanks to @neurobordeaux.bsky.social and CNRS for the support, which enables us to keep building a more inclusive research environment.
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Reposted by Alessandro Piccin
Stefano Palminteri @stepalminteri.bsky.social · 14/04/2025
🚨 New study alert! 🚨 Ever wondered if rats and humans learn in the same way? 🐭🧑‍🔬 We tested this — and the answer is yes, at least when it comes to how we value rewards in context. (with @shaunaparkes.bsky.social Lachlan Ferguson, Magdalena Soukupova) 🧵Thread 👇 1/ www.biorxiv.org/content/10.1...
biorxiv.org
Reference Point-Dependent Reinforcement Learning in Humans and Rats
Previous studies indicate that rewards and punishments in reinforcement learning are encoded in a relative manner. Reference point-dependence, a valuation bias shared by eminent adaptation level and p...
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Alessandro Piccin @apiccin.bsky.social · 05/03/2025
Just UK and NA though... 😢
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Alessandro Piccin @apiccin.bsky.social · 15/02/2025
Merci Dr Y 🙏
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Alessandro Piccin @apiccin.bsky.social · 15/02/2025
Grazie Francesco :)
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Alessandro Piccin @apiccin.bsky.social · 14/02/2025
Thanks Vincent!! It's a full noradrenaline-dopamine project, so a lot of fun questions 😉
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Alessandro Piccin @apiccin.bsky.social · 14/02/2025
It's official! I've been awarded an #MSCA Postdoctoral Fellowship to work w/ @miriammelis.bsky.social in Cagliari 🏖️🇮🇹 #SPICE-FONTS will investigate the role of my fav neurotransmitter #noradrenaline in neurodevelopmental deficits caused by prenatal #cannabis exposure 🤰🌿 Grateful @ec.europa.eu 🙏🇪🇺
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Alessandro Piccin @apiccin.bsky.social · 08/02/2025
Grazie Mario!
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Alessandro Piccin @apiccin.bsky.social · 08/02/2025
Despite the translational failure of CRF1 receptor antagonists (see pmc.ncbi.nlm.nih.gov/articles/PMC...), these results show how some of these compounds might find new life in treating opioid-induced social deficits, which are known for worsening the clinical outcome of opioid use disorders.
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Alessandro Piccin @apiccin.bsky.social · 08/02/2025
At last, we show that, in male mice, antalarmin abolishes morphine-induced firing in neurons co-expressing OXY and AVP, but not in neurons expressing only AVP, thereby suggesting a sex-dependent mechanism of action involving CRF1 receptors and oxytocinergic neurons of the PVN.
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Alessandro Piccin @apiccin.bsky.social · 08/02/2025
Then, we replicate these results using the CRF1 genetic mouse model, and show that CRF1 receptor-deficiency prevents morphine-induced sociability deficits and firing of PVN neurons in a gene expression-dependent manner.
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Alessandro Piccin @apiccin.bsky.social · 08/02/2025
In parallel, we show that antalarmin also eliminates morphine-induced firing of PVN neurons in a sex-dependent manner.
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Alessandro Piccin @apiccin.bsky.social · 08/02/2025
First of all, we show that per os administration of the CRF1 receptor antagonist antalarmin completely abolishes sociability deficits induced by morphine, although exclusively in male mice.
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Alessandro Piccin @apiccin.bsky.social · 08/02/2025
Briefly, we investigated whether #CRF1 receptors play a role in the social deficits induced by #morphine and whether they affect the activity of #oxytocin (OXY) and #vasopressin (AVP) -expressing neurons of the paraventricular nucleus of the hypothalamus (#PVN).
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Alessandro Piccin @apiccin.bsky.social · 08/02/2025
Let's just say that when these experiments took place I had no idea where Wuhan was or how to change a diaper. So, you can just imagine how relieved I am to see this work out! A smooth and positive experience with the new @elife.bsky.social model, which I recommend.
elifesciences.org
Disruption of the CRF1 receptor eliminates morphine-induced sociability deficits and firing of oxytocinergic neurons in male mice
Both genetic and pharmacological studies reveal an essential role for the CRF1 receptor in social behavior deficits induced by a single morphine administration in male, but not in female, mice.
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