CELEBRATE FREEDOM. IGNITE YOUR REBELLION Independence Day is about the fight for freedom. The American Revolution was a stand against tyranny and kings. That same spirit has lived on—from the Boston T...

McMahon's letter announced that the U.S. government would no longer provide federal funding to Harvard University.

The White House wants to alter life for U.S. hunters, anglers, RVers, off-road-vehicle drivers, backpackers, birdwatchers and hikers.

Join us for our next in person meeting for Indivisible NEO at St. Paul’s Episcopal Church in Cleveland Heights. What to expect: A general meeting open to all where you’ll get updates on our latest e...

Republicans are selling us out to help billionaires like Elon Musk get even richer. They’re planning to cut Medicaid, SNAP, and other vital programs to fund massive tax cuts for billionaires. Members ...

The right's crusade against DEI and trans people is threatening disabled Americans — and straining the coalition behind the Americans with Disability Act.

Synthetic lethality exploits the genetic vulnerabilities of cancer cells to enable a targeted, precision approach to treat cancer1. Over the past 15 years, synthetic lethal cancer target discovery approaches have led to clinical successes of PARP inhibitors2 and ushered several next-generation therapeutic targets such as WRN3, USP14, PKMYT15, POLQ6 and PRMT57 into the clinic. Here we identify, in human cancer, a novel synthetic lethal interaction between the PELO–HBS1L and SKI complexes of the mRNA quality control pathway. In distinct genetic contexts, including 9p21.3-deleted and high microsatellite instability (MSI-H) tumours, we found that phenotypically destabilized SKI complex leads to dependence on the PELO–HBS1L ribosomal rescue complex. PELO–HBS1L and SKI complex synthetic lethality alters the normal cell cycle and drives the unfolded protein response through the activation of IRE1, as well as robust tumour growth inhibition. Our results indicate that PELO and HB

It feels like yesterday when I boarded a plane for Portland, Oregon, to attend my first in-person Science Talk conference in 2022. Since then, I have attended the conference both in person and virtua...

A new study finds that a common blood test for ovarian cancer may miss some Black and Native American patients, delaying their treatment.

During the hearing, Rep. Gerry Connolly made a parliamentary inquiry with Chair James Comer about Mace using the slur.

Former Democratic Congressional candidate Michael B. Moore, who challenged Representative Nancy Mace (R-SC) in the November election, and newly elected HCDP Chair Judy Davies, urged Democrats last nig...

Join Gov. Walz, Ben Wikler and the Democratic Party of Wisconsin as WE FIGHT back and highlight that the Wisconsin Supreme Court CANNOT be bought! We want to hear from YOU! Elon Musk is trying to buy a seat on the Wisconsin Supreme Court. He knows whoever wins the April 1st election will be the tie-breaking vote in court decisions, and he’s bankrolling extreme right-wing candidate Brad Schimel to ensure a rubber stamp on the MAGA agenda in Wisconsin. Come to our town hall and LET YOUR VOICE BE HEARD!

This searchable map shows you early voting and dropbox info for hundreds of villages, towns, and cities across Wisconsin. Enter the address you're registered at and your options will pop up!

Data from 2017 show that costs associated with dust were second only to hurricanes when comparing billion-dollar disasters.

Today, a federal judge in San Francisco ordered the Trump administration to offer reinstatement to all probationary employees previously fired from the departments of Agriculture, Defense, Energy, Int...

A new study examines the geographic and demographic connections between health and a lack of consistent access to food, finding that this link is particularly strong in the South.

The results of Hera's flyby could ultimately tell us whether Deimos is a captured asteroid or made from debris from a giant impact on Mars.