iiinova — where your digital self keeps evolving

Andrew Harrison

@andrewgharrison6.bsky.social

318 followers 100 following 8 posts

Postdoctoral Research Fellow studying innate immune signaling pathways in Ivan Zanoni's Lab at Boston Children's Hospital @harvardmed | PhD '24 at UCONN Health with Penghua Wang

Posts Replies Media

Andrew Harrison @andrewgharrison6.bsky.social · 21/11/2024

Thank you, Priya! Hope all is well!!

000

Andrew Harrison @andrewgharrison6.bsky.social · 21/11/2024

Thank you!

010

Andrew Harrison @andrewgharrison6.bsky.social · 21/11/2024

Thanks, Laura! Hope all is well!

010

Andrew Harrison @andrewgharrison6.bsky.social · 20/11/2024

Also thx to @madison-strine.bsky.social, @lozanzi.bsky.social, @rathinamva.bsky.social, and all those who helped contribute to this work (& are not yet on BlueSky)!

020

Andrew Harrison @andrewgharrison6.bsky.social · 20/11/2024

Thanks to Jon Bogan at Yale for GLUT4 expertise! Danny Yang for his immense help during revision & my PhD. Thanks to our collaborators, co-authors, reviewers + editors at NI for improving the work, friends&family. Also thx to @takarginov.bsky.social, @kailasanvanaja.bsky.social

120

Andrew Harrison @andrewgharrison6.bsky.social · 20/11/2024

A big thank you to mentor at UCONN, Penghua Wang. W/o his guidance + support this wasn't possible. We were in lockstep throughout my PhD & his trust in his students to have autonomy definitely prepared me for my next steps as a scientist.

100

Andrew Harrison @andrewgharrison6.bsky.social · 20/11/2024

This work reveals GLUT4 tethers RLRs to the plasma membrane, thus inhibiting signal transduction and antiviral immunity. Akin to other transporters, we now show that GLUT4 can have underappreciated roles in regulating innate immunity independent of solute transport.

110

Andrew Harrison @andrewgharrison6.bsky.social · 20/11/2024

Hi everyone! New to Bluesky, but happy to share the final chapter of my PhD @uconnhealth.bsky.social out today in Nature Immunology! Here, we uncovered a noncanonical function of the glucose transporter GLUT4 in regulating RLR signaling in muscle and adipocytes www.nature.com/articles/s41...

nature.com

UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling - Nature Immunology

Wang and colleagues show that in skeletal muscle cells and cardiomyocytes, the glucose transporter GLUT4 is a negative regulator of RIG-I-like receptor signaling during viral infection by redistributi...

48318