Announcing the 2025 Schmidt Polymaths: Eight exceptional scientists who embody the future of interdisciplinary research. Selected from universities worldwide, each Schmidt Polymath receives up to $2....

The Diffuse Project

The Diffuse Project

A new $5 million initiative, funded by the Astera Institute with experimental work conducted at the Cornell High Energy Synchrotron Source, aims to make diffuse scattering accessible to the public and...

Discovered nearly 70 years ago, the allosteric regulation of Escherichia coli aspartate transcarbamoylase (ATCase) is discussed in every biochemistry textbook. ATCase catalyzes the first step in pyrim...

A long-standing goal in X-ray crystallography has been to extract information about the collective motions of proteins from diffuse scattering: the we…

Understanding the structural dynamics associated with enzymatic catalysis has been a long-standing goal of structural biology. A wide range of motions, from small side-chain fluctuations to large doma...