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Chromatin labeling and imaging group @andimaging.bsky.social · 05/10/2026

Detect and see chains of polyP! Our far-red fluorogenic SiX-DPA-Zn sensor detects inorganic polyP in cells, gels, in vitro assays & by STED microscopy. Congratulations to the authors Kenji and Ruta. JACS @jacs.acspublications.org doi.org/10.1021/jacs...

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Chromatin labeling and imaging group @andimaging.bsky.social · 23/06/2026

PolyP probe SiX-DPA-Zn, BRIGHT Red signal, works in cells, gels, in vitro assays and STED microscopy. Now on @biorxivpreprint.bsky.social www.biorxiv.org/content/10.6... . Congratulations to the authors Kenji and Ruta. #BioRxiv #ChemicalBiology #Fluorescence #Microscopy #Polyphosphate

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Chromatin labeling and imaging group @andimaging.bsky.social · 09/06/2026

Make HDAC6 visible again! 6SiR-C3-NextA is a selective far-red probe for imaging endogenous HDAC6 in living cells across diverse mammalian cell types. Done by @vanthang.bsky.social at @mpi-nat.bsky.social Now in JACS @pubs.acs.org pubs.acs.org/doi/10.1021/...

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Chromatin labeling and imaging group @andimaging.bsky.social · 15/05/2026

New preprint ! OptiFoot allows imaging of protein–nucleic acid interactions and places them into sequence context using Optical Genome Mapping, bridging super-resolution microscopy with single-molecule genomic analysis. #Genomics #Chromatin #Microscopy #bioRxiv www.biorxiv.org/content/10.6...

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Chromatin labeling and imaging group @andimaging.bsky.social · 15/04/2026

News & Views in @natchembio.nature.com : CenSpark offers a new perspective on microtubule organization—moving beyond tubulin to capture higher-order structure in live cells. #AcademicPublishing #ResearchImpact #Imaging www.nature.com/articles/s41...

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Chromatin labeling and imaging group @andimaging.bsky.social · 12/03/2026

Just published in JACS Au pubs.acs.org/doi/10.1021/... We show that the remarkable stability of proline-derived cofactors enabling efficient DNA labeling using methyltransferases—even under harsh conditions. Thanks to the contributors: Jonas and Rūta.

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Chromatin labeling and imaging group @andimaging.bsky.social · 27/01/2026

New Year, New Microscope! We just got upgraded to Abberior MIRAVA POLYSCOPE — confocal → MATRIX → STED. First test looks good, large field-of-view and nice STED images using our probes. @abberior.rocks @stefanhelllabs.bsky.social @mpi-nat.bsky.social #microscopy #livecell #fluorescence #bioimaging

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Chromatin labeling and imaging group @andimaging.bsky.social · 26/01/2026

New preprint! The remarkable stability of proline-derived cofactors opens efficient DNA labeling possibility using methyltransferases even at harsh conditions. www.biorxiv.org/content/10.6... Congratulations to Ruta and Jonas . #Biochemistry #DNA #Fluorescence

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Chromatin labeling and imaging group @andimaging.bsky.social · 29/12/2025

Wish all of You Merry Christmas and a Happy New Year!!! Enjoy AI-generated card for Chromatin labeling and imaging @andimaging.bsky.social

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Chromatin labeling and imaging group @andimaging.bsky.social · 17/12/2025

New preprint! We systematically evaluate red-shifted rhodamine-based DNA probes for in vivo imaging. Congratulations to Kamila and Shalini et al! Job done at @mpi-nat.bsky.social and @imprsgs.bsky.social ! Read more if you want to know which isomer is the best: www.biorxiv.org/content/10.6... .

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Chromatin labeling and imaging group @andimaging.bsky.social · 15/12/2025

6SiR-C3-NextA is bright far-red, cell-permeable probe for live-cell selective HDAC6 imaging. Congratulations to Van-Thang Nguyen et al. @vanthang.bsky.social from @imprsgs.bsky.social ! Developed at @mpi-nat.bsky.social nat.bsky.social and published on BioRxiv www.biorxiv.org/content/10.6... .

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Chromatin labeling and imaging group @andimaging.bsky.social · 13/12/2025

Celebrating 2nd PhD student of the group! 🎓 Van-Thang Nguyen (@vanthang.bsky.social) from the Chromatin Labeling & Imaging group successfully defended his thesis through the @imprsgs.bsky.social program at @mpi-nat.bsky.social. A smooth and impressive defense — and his paper is coming soon… 👀📄

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Chromatin labeling and imaging group @andimaging.bsky.social · 12/12/2025

We have introduced a new biocompatible sulfonium-based building block for generation of non-cytotoxic covalent fluorescent probes. The proof-of-concept paper is out in Nature Communications: rdcu.be/eUn8F Great job done by @mauvray.bsky.social at @mpi-nat.bsky.social Enjoy reading!

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Chromatin labeling and imaging group @andimaging.bsky.social · 08/03/2025

The updated Team of @andimaging.bsky.social . We will keep you posted with our newest developments.

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Chromatin labeling and imaging group @andimaging.bsky.social · 26/12/2024

Wish all of You Merry Christmas and a Happy New Year!!! Enjoy DALL-E AI-generated card for Chromatin labeling and imaging @AndImaging

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Chromatin labeling and imaging group @andimaging.bsky.social · 11/12/2024

Finally, we have the 1st PhD student Shalini Pradhan @ShaliniPradha19 from Chromatin labeling and imaging group from @IMPRS_GS program at @mpi_nat . It was challenging to make the full program in a single day, but we succeed.

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Chromatin labeling and imaging group @andimaging.bsky.social · 09/03/2023

Finally, our paper describing more rhodamine 4-isomers and >80 probes is out in @NatureComms : doi.org/10.1038/s41467-023-36913-2 Enjoy a four color live-cell dynamics of nucleus (magenta), mitochondria (cyan), lysosomes (yellow) and microtubules (gray). All stained with 4-isomers.

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Chromatin labeling and imaging group @andimaging.bsky.social · 03/02/2023

Label size is becoming an important issue in modern #fluorescence #microscopy or #nanoscopy. See size comparison of the commonly used tags and labeling approaches - antibody, GFP, Halo-tag, SNAP-tag, nanobody or small probe (5-610CP-Hoechst). Happy #FluorescenceFriday! #SciArt

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Chromatin labeling and imaging group @andimaging.bsky.social · 27/01/2023

Let's look at the molecular details of the tubulin probe's action. Enjoy computational model of the tubulin labeled with 4-TMR-LTX. The probe binds only to one subunit - beta-tubulin. Happy #FluorescenceFriday ! #SciArt #ChemTwitter #Fluorescence

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Chromatin labeling and imaging group @andimaging.bsky.social · 20/01/2023

Rhodamines exist in two forms: Zwitterion (fluorescent) and Spirolactone (non-fluorescent). Zwitterion is hydrophilic and likes water, but Spirolactone is hydrophobic and keeps its tail out of water. See our visualization of these two forms and enjoy #FluorescenceFriday !!!

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Chromatin labeling and imaging group @andimaging.bsky.social · 23/12/2022

Our group wish all of you Merry #Christmas and #HappyNewYear ! We wish all of you good health and peaceful cozy celebrations. Enjoy our postcard made of amazing structures which we observed in living cells. #AcademicTwitter #SciArt #FluorescenceFriday #Christmas2022

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Chromatin labeling and imaging group @andimaging.bsky.social · 16/12/2022

Live-cell imaging of EB3-GFP tagged is amazing. Enjoy and follow the plus ends of microtubules (yellow) in the network of tubulin (magenta). Happy #FluorescenceFriday ! #SciArt #ChemTwitter #Fluorescence

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Chromatin labeling and imaging group @andimaging.bsky.social · 09/12/2022

Please RT ! We are looking for a seriously motivated #PhD student to join in 2023. Join us, if you are passionate about chromatin labeling and imaging using #STED and #MINFLUX microscopy! Apply to @IMPRS_GS: t.co/it4nFJ3OKb #AcademicTwitter #PhDposition #Research

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Chromatin labeling and imaging group @andimaging.bsky.social · 02/12/2022

Live-cell imaging is extremely entertaining. Enjoy dancing mitochondria (orange) in the network of tubulin (yellow) and vimentin (cyan) next to the nucleus (green). Happy #FluorescenceFriday! #SciArt #ChemTwitter #Fluorescence

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Chromatin labeling and imaging group @andimaging.bsky.social · 25/11/2022

Today we have made some rhodamine lava in a flask!!! Enjoy #FluorescenceFriday and have a nice weekend! #SciArt #ChemTwitter #Fluorescence

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Chromatin labeling and imaging group @andimaging.bsky.social · 18/11/2022

Nice colors of fluorescent dyes exited by chemical reaction!!! Yes, it's Chemiluminescence! We hope it also counts for #FluorescenceFriday #Science #SciArt #RealTimeChem #Chemtwitter

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Chromatin labeling and imaging group @andimaging.bsky.social · 11/11/2022

Back to #imaging and testing of lice-cell probes. #Centrosome and primary cilium in 3D #STED. Today is 11.11, and we wish you a happy #FluorescenceFriday ! #Science #SciArt #RealTimeChem #Chemtwitter

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Chromatin labeling and imaging group @andimaging.bsky.social · 04/11/2022

Nice and glowing. Coumarin 6 is a derivative of one of the coumarin. Coumarins' chemical synthesis was started in 1868 by W. H. Perkin. #FluorescenceFriday #fluorescentfriday #Science #SciArt #RealTimeChem #Chemtwitter

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Chromatin labeling and imaging group @andimaging.bsky.social · 16/09/2022

We have a new #chemistry lab at @mpi_nat which is nice to use for the synthesis of fluorescent probes. Let's start #FluorescenceFriday ! Enjoy ! #biology #photography #imaging #sciart

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Chromatin labeling and imaging group @andimaging.bsky.social · 24/06/2022

Today is an official founding celebration of our Max Planck Institute for Multidisciplinary Sciences (@mpi_nat)! It's also #Midsummer Day or #SaintJohn 's Day, and #FluorescenceFriday which we are celebrating by creating a glowing logo of our institute! #SciArt #GLOW

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Chromatin labeling and imaging group @andimaging.bsky.social · 23/06/2022

We started to work on imaging of mitochondria. They look nice and jumpy. Now we can understand our neighbors' and colleagues' passion from @JakobsLab Read more: www.biorxiv.org/content/10.1101/202…

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Chromatin labeling and imaging group @andimaging.bsky.social · 22/06/2022

New biocompatible probes for actin show more dynamics! We see not only F-actin, but also G-actin! Read more about old Jasplakinolide probes and their improved versions here: t.co/YnSjEljhiK and t.co/wtXaYnyXg0

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Chromatin labeling and imaging group @andimaging.bsky.social · 17/06/2022

#FluorescenceFriday is here, and we have a beautiful movie of #fluorescence #microscopy to share with You. Enjoy dancing #mitochondria (red-hot) and #lysosomes (cyan) in #tubulin network (gray) next to #nucleus (blue). Find #centrosome ! Read more: t.co/f7XiKiBgOp

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Chromatin labeling and imaging group @andimaging.bsky.social · 16/06/2022

Inflation has also hit our group! By putting sanctions on the number of synthesis steps, we got the following image. Need more information, read here: www.biorxiv.org/content/10.1101/202…

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Chromatin labeling and imaging group @andimaging.bsky.social · 15/06/2022

We play with live-cell staining using our new probes! See jumping mitochondria (yellow) embedded in tubulin (cyan) and actin (magenta) cytoskeleton close to nucleus (green). Read more: www.biorxiv.org/content/10.1101/202…

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Chromatin labeling and imaging group @andimaging.bsky.social · 14/06/2022

Moving towards Addprobe (@Addgene analog) = cheap and highly efficient synthesis of > 20 rhodamines' 4-isomers and >80 probes. Let's stain everything! Enjoy live cell movie Vimentin (cyan), DNA (green), tubulin (yellow) and mitochondria (red-hot)! Read: t.co/f7XiKiBgOp

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Chromatin labeling and imaging group @andimaging.bsky.social · 08/05/2022

Our latest imaging experiment: enjoying spring together with beautiful cherry blossom tree at @mpi_nat #spring #cherryblossom #Pink #imaging #photography #SAKURABLOOM

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Chromatin labeling and imaging group @andimaging.bsky.social · 25/04/2022

DNA can have many forms. Enjoy our favorite A-, B- and Z-DNA structures. Happy DNA day!!! 🎉🥳

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Chromatin labeling and imaging group @andimaging.bsky.social · 24/02/2022

This morning, we got a sad message from an excellent chemistry company @EnamineLtd located in #Ukraine being invaded by #Russian troops. It seems that Western Europe has not learned much from the history which is repeating.

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Chromatin labeling and imaging group @andimaging.bsky.social · 18/02/2022

We have fun with neuronal culture! Enjoy covering big area and nice tubulin network of living neurons and glia cells stained with tubulin probe. Looks like drawing form old biology books ;) #FluorescenceFriday #RealTimeChem #Chemtwitter #SciArt #AcademicTwitter #neuroscience

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Chromatin labeling and imaging group @andimaging.bsky.social · 14/01/2022

Actin is always nice to image! Enjoy 100 MPixel STED image (300x300um) of live neuronal culture. Amazing zooming of nanoscopy image shows stripes everywhere. The first image of the year for #FluorescenceFriday! #RealTimeChem #Chemtwitter #SciArt

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Chromatin labeling and imaging group @andimaging.bsky.social · 24/12/2021

Dear all microscopy, fluorescent probes, super-resolution, live-cell imaging and other loving science fans. We wish you Merry Christmas and Happy New Year!!! #AcademicTwitter #SciArt #FluorescenceFriday #Christmas2021

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Chromatin labeling and imaging group @andimaging.bsky.social · 17/12/2021

Let's play with fluorescent sticks this #FluorescenceFriday! Enjoy fluorescent rhodamine/carbopyronine ! #RealTimeChem #Chemtwitter #SciArt

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Chromatin labeling and imaging group @andimaging.bsky.social · 06/12/2021

Let‘s start this week with an image created by t.co/xdO1dfpD2F based on the title of our most recent paper published in @ChemicalBiology: t.co/oe25AQwsHF It’s definitely blinking 😉, but is it tubulin? #SciArt #MysticLabs #scifi #AI t.co/OBCQqoKW9l

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