iiinova — where your digital self keeps evolving

Reposted by Aino-Maija Leppä

The Francis Crick Institute @crick.ac.uk · 11/03/2025

Researchers from the Crick, @dkfz.bsky.social and the German Red Cross Blood Donation Centre have found beneficial genetic changes that arise in the blood stem cells of people who regularly donate blood cells. www.crick.ac.uk/news-and-fea...

crick.ac.uk

Beneficial genetic changes observed in regular blood donors

Researchers at the Francis Crick Institute have identified genetic changes in blood stem cells from frequent blood donors that support the production of new, non-cancerous cells.

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Reposted by Aino-Maija Leppä

verat-h.bsky.social @verat-h.bsky.social · 18/02/2025

Thrilled to share that our work from Trumpp Lab @hi-stem @dkfz.bsky.social is out in Nature. We provide the first single-cell data on neurons infiltrating pancreatic tumors, offering new insights into cancer therapy. #cancerneuroscience @cn-hd.bsky.social www.nature.com/articles/s41...

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Reposted by Aino-Maija Leppä

Eric Topol @erictopol.bsky.social · 18/02/2025

Today @nature.com on how pancreatic cancer can hijack our nervous system and how denervation may be therapeutic www.nature.com/articles/s41...

nature.com

Characterization of single neurons reprogrammed by pancreatic cancer - Nature

Nature - Characterization of single neurons reprogrammed by pancreatic cancer

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Reposted by Aino-Maija Leppä

Constantin Ahlmann-Eltze @const-ae.bsky.social · 03/01/2025

After 4y in the making, I am super excited that my main PhD project is published 🎉🥳🎉🎉🥳 www.nature.com/articles/s41... LEMUR is a tool to analyze multi-condition single-cell data and model differential expression as a continuous function of the cell-state space. Some highlights⬇️

Overview of the LEMUR steps: (1) subspace alignment, (2) differential expression, (3) DE neighborhoods, (4) pseudobulking.

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Aino-Maija Leppä @amleppa.bsky.social · 25/11/2024

I'm very thankful to everyone involved in the study! The project would not have been possible without my co-firsts Karen Grimes and Hyobin Jeong and co-lasts Andreas Trumpp, Jan Korbel and Ashley Sanders 🎉 🎊 5/5

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Aino-Maija Leppä @amleppa.bsky.social · 25/11/2024

In another patient with paired pre- and post-treatment samples, two distinct subclones persisted post venetoclax-based treatment. Both had subclone-specific mechanisms to further resistance: a shift toward MEP-like cells and NF1 loss. Go and read more about the other cases! 📜 4/5

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Aino-Maija Leppä @amleppa.bsky.social · 25/11/2024

For example, in one patient the sublclone driving relapse had a seismic amplification, upregulated DNA damage response and it also engrafted in mice. We could even see cell-to-cell differences in the copy-number states of the seismic amplification! 🌋 3/5

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Aino-Maija Leppä @amleppa.bsky.social · 25/11/2024

We integrated single-cell resolution structural variants, nucleosome occupancy, gene expression and surface proteins to study subclonal growth patterns in complex karyotype AML patient samples 🧬 2/5

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Aino-Maija Leppä @amleppa.bsky.social · 25/11/2024

Extremely proud to see my PhD project exploring intra-tumor heterogeneity in complex karyotype AML finally out in @NatureGenet! 🎉 👩🏻‍🔬 They say that 10,000 hours make you an expert, so I guess after more than five years of work I’m half-way there 😅 ⬇️1/5 www.nature.com/articles/s41...

nature.com

Single-cell multiomics analysis reveals dynamic clonal evolution and targetable phenotypes in acute myeloid leukemia with complex karyotype - Nature Genetics

An integrated single-cell multiomic analysis of complex karyotype acute myeloid leukemia characterizes intratumoral heterogeneity and highlights links to therapeutic sensitivities.

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