INTRODUCTION With anti-amyloid beta (Aβ) therapies approved for Alzheimer's disease (AD), surrogate biomarkers are needed to monitor clinical treatment efficacy. Therefore, we systematically compare.....

UCL Hawkes Institute seeks postdoc to develop joint text-vision AI models for MRI analysis in dementia and longevity, led by Prof James Cole at MANIFOLD lab.

Background Aggregated alpha-Synuclein (αSyn) is a hallmark pathology in Parkinson’s disease but also one of the most common co-pathologies in Alzheimer’s disease (AD). Preclinical studies suggest that...

We are working to solve the biggest mysteries in bioscience.

EDoN Research Assistant Research Assistant responsible for harmonizing data, linking with traditional phenotypes from clinical assessments, biomarkers, and imaging, and beginning analysis.

Vascular dementia is one of the most common types of dementia and is growing in prevalence. There are currently no effective treatments for the condition. A new UK DRI project, funded by the British H...

Are you looking for an exciting PostDoc position working in brain imaging and cognition? Do you have a PhD or near to completion using imaging methods? Are you interested in how strategies can improve...

Vacancy for a Senior Research Technician to join Professor Sarah Tabrizi’s research group at UCL to provide maternity cover at the Huntington’s Disease Centre.

Aβ induces neuronal hyperconnectivity, which promotes tau spreading from temporal lobe epicenters to connected brain regions in Alzheimer’s disease.

imageimageThis study examined whether sex, age, microglial activation or ApoE4 modulates the Aβ to p-tau axis, a critical event in the amyloid cascade that triggers the progression of Alzheimer’s disease (AD) from amyloidosis towards tauopathy. ...

De Bruin et al. report that traumatic brain injury does not inherently elevate the Alzheimer’s pathologies amyloid-β or tau, but is associated with their u

Research underscores involvement of the brain’s immune system

Tau PET has attracted increasing interest as an imaging biomarker for 4-repeat (4R)-tauopathy progressive supranuclear palsy (PSP). However, the translation of in vitro 4R-tau binding to in vivo tau P...