Reposted by Amber BartonWellcome Sanger Institute @sangerinstitute.bsky.social · 07/01/2026By sequencing the bacteria responsible for yaws, a debilitating childhood disease, experts have uncovered new insights into how these bacteria re-emerge and evade treatment 🧬 Find out how these can be used to help inform public health interventions ⤵️ www.sanger.ac.uk/news_item/ge...sanger.ac.ukGenomics uncovers new ways to target chronic childhood diseaseBy sequencing the bacteria that cause the neglected disease yaws, researchers have found that while mass treatment can be successful, it can cause resistant strains to develop. They suggest that publi... 124
Amber Barton @amberbarton.bsky.social · 07/01/2026Really pleased to see our work on yaws, and how mass drug administration shapes Treponema genomes, published in @lancetmicrobe.bsky.social! sanger.ac.uk/news_item/genomics-uncovers-new-ways-to-target-chronic-childhood-disease/ www.thelancet.com/journals/lan...sanger.ac.ukGenomics uncovers new ways to target chronic childhood diseaseBy sequencing the bacteria that cause the neglected disease yaws, researchers have found that while mass treatment can be successful, it can cause resistant strains to develop. They suggest that publi... 054
Reposted by Amber BartonMichael Marks @drmichaelmarks.bsky.social · 07/01/2026Out @lancetmicrobe.bsky.social & led @amberbarton.bsky.social We used WGS to look at Treponema population dynamics during community MDA for yaws tinyurl.com/bd6zu6xm Intriguingly found sublineage associated w longer ulcer duration & lower antibody titres. Whether occurs in syphilis needs exploring 086
Amber Barton @amberbarton.bsky.social · 05/02/2025Delighted to share our preprint on the evolution of pandemic cholera at its global source in the ganges basin! doi.org/10.1101/2025.02.03.25321585medrxiv.orgEvolution of Pandemic Cholera at its Global SourceThe seventh pandemic of cholera, caused by the 7th Pandemic El Tor Lineage (7PET) Vibrio cholerae, was previously shown to have emanated in three global waves from the Bay of Bengal, bordering Banglad... 162
Amber Barton @amberbarton.bsky.social · 13/12/2024Had a wonderful time at 17th Asian Conference on Diarrhoeal Disease and Nutrition in Nepal- fantastic to meet up with infection researchers from all over the world, share results, chair a session for the first time and explore Kathmandu! 140
Reposted by Amber BartonMat Beale @typemat12.bsky.social · 29/10/2024Pleased to share this preprint on Yaws transmission dynamics following mass azithromycin administration, led by Amber Barton www.medrxiv.org/content/10.1... Following MDA campaign, we sequenced >half of infections, showing recrudescence driven by existing lineages & persistence linked to key SNPs.medrxiv.orgThe Effect of Repeated Mass Drug Administration on the Transmission of Yaws: A Genomic Epidemiology StudyBackground: Yaws, a neglected tropical disease caused by Treponema pallidum subspecies pertenue, has evaded eradication, in part due to a high proportion of asymptomatic cases. A cluster-randomised tr... 1910