iiinova — where your digital self keeps evolving

Reposted by Amber Barton

Wellcome Sanger Institute @sangerinstitute.bsky.social · 07/01/2026

By sequencing the bacteria responsible for yaws, a debilitating childhood disease, experts have uncovered new insights into how these bacteria re-emerge and evade treatment 🧬 Find out how these can be used to help inform public health interventions ⤵️ www.sanger.ac.uk/news_item/ge...

sanger.ac.uk

Genomics uncovers new ways to target chronic childhood disease

By sequencing the bacteria that cause the neglected disease yaws, researchers have found that while mass treatment can be successful, it can cause resistant strains to develop. They suggest that publi...

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Reposted by Amber Barton

Michael Marks @drmichaelmarks.bsky.social · 07/01/2026

Out @lancetmicrobe.bsky.social & led @amberbarton.bsky.social We used WGS to look at Treponema population dynamics during community MDA for yaws tinyurl.com/bd6zu6xm Intriguingly found sublineage associated w longer ulcer duration & lower antibody titres. Whether occurs in syphilis needs exploring

The image shows two box and whisker plots. The left hand plot shows the duration of peoples ulcers stratified by sub-lineage and demonstrates that one of these sub-lineages has a longer duration of ulcers than the others. The right hand plot shows the titre of treponemal antibodies stratified by sub-lineage and demonstrates that the same sub-lineage is also associated with much lower antibody titres than the others.

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Amber Barton @amberbarton.bsky.social · 13/12/2024

Had a wonderful time at 17th Asian Conference on Diarrhoeal Disease and Nutrition in Nepal- fantastic to meet up with infection researchers from all over the world, share results, chair a session for the first time and explore Kathmandu!

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Reposted by Amber Barton

Mat Beale @typemat12.bsky.social · 29/10/2024

Pleased to share this preprint on Yaws transmission dynamics following mass azithromycin administration, led by Amber Barton www.medrxiv.org/content/10.1... Following MDA campaign, we sequenced >half of infections, showing recrudescence driven by existing lineages & persistence linked to key SNPs.

medrxiv.org

The Effect of Repeated Mass Drug Administration on the Transmission of Yaws: A Genomic Epidemiology Study

Background: Yaws, a neglected tropical disease caused by Treponema pallidum subspecies pertenue, has evaded eradication, in part due to a high proportion of asymptomatic cases. A cluster-randomised tr...

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