iiinova — where your digital self keeps evolving

Reposted by Prof Amanda J Farrin

Dr Victoria Shepherd @vickylshepherd.bsky.social · 23/02/2026

With CONSULT now ending, we are delighted to share two reports that summarise our findings 1/n CONSULT aimed to support ethical inclusion in research of adults with impaired capacity to consent through series of studies & methodological interventions: 📆5 yrs 📝9 papers (+ 1 in review) 🗝️8 key findings

131

Reposted by Prof Amanda J Farrin

BJGP @bjgp.org · 23/01/2026

No.3 #BJGPTop10 Irritable bowel syndrome: Trying low-dose amitriptyline for IBS outweighed patients' concerns doi.org/10.3399/BJGP... @uos-primarycare.bsky.social @hazeleveritt.bsky.social @riddmj.bsky.social @amandafarrin.bsky.social #ATLANTISTrial #IBS #DigestiveHealth #PrimaryCare #BJGP #research

145

Reposted by Prof Amanda J Farrin

Richard Hooper @richardhooper.bsky.social · 01/10/2025

I'm doing a webinar in two weeks (15 Oct 1-2pm BST), part of NIHR Research Support Service's Methods Academy series, on the age-old question: should I do a stepped wedge trial? Free registration, details here: tinyurl.com/z6cjvce3 @nihr-rss.bsky.social @wiphcem.bsky.social @qmul-wiph.bsky.social

11315

Reposted by Prof Amanda J Farrin

UK CTU Network @ukctunetwork.org · 10/10/2025

Great to have so many engaged people in the room! More workshops are planned for 2026. Follow us here and on LinkedIn find out about future training opportunities. www.linkedin.com/company/ukcrc-registered-ctu-network/ #UKCTUNetwork #HTBAGCI #ClinicalTrials

121

Reposted by Prof Amanda J Farrin

Sarah Alderson @imp-sci-saraha.bsky.social · 06/06/2025

Fern Harvey’s fab poster presentation of her systematic review on process evaluations for complex intervention trials. Better reporting of context, mechanisms of action and fidelity would enable greater learning about successful interventions #ImpSci #EIE2025 @au-primarycareuol.bsky.social

1134

Reposted by Prof Amanda J Farrin

Marion Campbell @marionkcampbell.bsky.social · 02/06/2025

A cluster randomised crossover design incorporates the principles of both cluster trials (where groups of individuals eg wards, schools etc are randomly assigned) and crossover trials where, in this case, the clusters cross over to different treatment/s for set time periods 2/7

141

Reposted by Prof Amanda J Farrin

Marion Campbell @marionkcampbell.bsky.social · 16/06/2025

At #CCR25, we saw some trials use a #CompositeOutcome (an endpoint that combines more than one outcome into a single measure) & also saw some of the problems these can throw up. I have discussed these before but thought it would be useful to revisit 1/9 #MethodologyMonday #120

1159

Reposted by Prof Amanda J Farrin

UK CTU Network @ukctunetwork.org · 20/03/2025

🚀 Exciting News! 🚀 Interested in or leading a clinical trial? Want to be the best Chief Investigator you can be? This updated course is for you! tinyurl.com/HTBAGCI #ClinicalTrials #CITraining @leedsctru.bsky.social @amandafarrin.bsky.social

Flyer advertising a training course on How to be a great chief investigator for clinical trials. Find out more via the following link https://tinyurl.com/HTBAGCI

059

Prof Amanda J Farrin @amandafarrin.bsky.social · 12/03/2025

Phew: ResearchFish submitted again for another year ✅️

010

Reposted by Prof Amanda J Farrin

Marion Campbell @marionkcampbell.bsky.social · 10/03/2025

A common issue in trials is how to accommodate multiple important outcomes. Approaches include composite outcomes or using the win ratio method (I have posted on these before). A newer method is the #DOOR (Desirability of Outcome Ranking) approach 1/7 #MethodologyMonday #113

3247

Prof Amanda J Farrin @amandafarrin.bsky.social · 13/02/2025

📢 Delighted our CHART trial is now OPEN to recruitment Massive effort from our @complexleedsctru.bsky.social trial team, @drandyclegg.bsky.social @vickigphysio.bsky.social & many others to get this complex study ready to go 🎉 🙏 @nihr.bsky.social for funding

053

Reposted by Prof Amanda J Farrin

Katie Gillies @katiegillies.bsky.social · 12/02/2025

Currently low response rates from CTU Directors (n=5), Programmers/Data Managers (n=0), & QA Managers (n=3) working in clinical trials. We need to know what these groups think the challenges are for greener trials. forms.office.com/e/fkeLD8HbMA Please complete &RT @ukctunetwork.bsky.social

forms.office.com

Microsoft Forms

0514

Prof Amanda J Farrin @amandafarrin.bsky.social · 03/02/2025

Follow @freshstart-uk.bsky.social for all updates from our @leedsctru.bsky.social @nihr.bsky.social programme grant. We've just moved over to this platform 🙂

031

Reposted by Prof Amanda J Farrin

Katie Gillies @katiegillies.bsky.social · 21/01/2025

Another link to survey as initial link problematic for some - forms.office.com/e/fkeLD8HbMA

forms.office.com

Microsoft Forms

102

Reposted by Prof Amanda J Farrin

Katie Gillies @katiegillies.bsky.social · 21/01/2025

Do you work on clinical trials? We need your help to understand the challenges to designing & delivering greener trials. Only 30 responses so far but we can all have a say on this topic. Please take 10 minutes to tell us what you think tinyurl.com/GreenTrials Please share across your networks

tinyurl.com

Microsoft Forms

21736

Reposted by Prof Amanda J Farrin

Marion Campbell @marionkcampbell.bsky.social · 28/01/2025

Interesting historical principles of clinical trial conduct … Rule 5 “the medical statistician has to be competent” … sure hope we’ve got that one sorted!

4117

Reposted by Prof Amanda J Farrin

Marion Campbell @marionkcampbell.bsky.social · 27/01/2025

An issue that often comes up is how to set a “non-inferiority margin” in a non-inferiority trial and how to ensure it is appropriate 1/8 #MethodologyMonday #109

23522

Prof Amanda J Farrin @amandafarrin.bsky.social · 22/01/2025

Welcome to bluesky @complexleedsctru.bsky.social 🎉 Please do follow our Complex Interventions Division account for our news of our training opportunities, trial progress and results, as well as signposting to relevant resources for Complex Intervention trialists 👇

020

Reposted by Prof Amanda J Farrin

Darren Dahly @statsepi.bsky.social · 14/01/2025

We've frustratingly allowed "real world" to become a deceptive synonym for "observations we happened haphazardly to make". I'd say half the studies that come to me now, the majority of which are useful but modest clinical audits, will have "real world" in the proposal title. It's magic!

717043

Reposted by Prof Amanda J Farrin

Prof Sheena Cruickshank @sheencr.bsky.social · 12/01/2025

I am not that surprised that more women quit academic publishing than men- this chimes with data showing fewer women get their papers published, grants funded if they lead them and that more women get pushed into support roles. We do need to do more to support and mentor female staff. 🧪

nature.com

Who’s quitting academia? Data reveal gender gaps in surprising fields

Even in scientific areas in which women are well represented, they are up to 40% more likely than men to leave research within 20 years.

824075

Prof Amanda J Farrin @amandafarrin.bsky.social · 09/01/2025

We're running our annual online Masterclass in Complex Interventions Evaluations over 3 days in January and February. Come and learn from our expert team of complex interventions trialists at @leedsctru.bsky.social Register now to reserve your place. Deadline 24 Jan. Link below 👇

0102

Prof Amanda J Farrin @amandafarrin.bsky.social · 05/01/2025

Just a wee bit of snow in Yorkshire 🥶❄️

040

Reposted by Prof Amanda J Farrin

Tim Morris @timpmorris.bsky.social · 03/01/2025

🤢 horrifying piece of work, which we’ll see idiots quoting. For goodness sake @jclinepi.bsky.social

8427

Prof Amanda J Farrin @amandafarrin.bsky.social · 02/01/2025

Happy New Year! May your 2025 be healthy, prosperous, and full of interesting research questions to explore!

091

Prof Amanda J Farrin @amandafarrin.bsky.social · 27/12/2024

Beautiful light from the late December sun in one of my favourite places today #PeakDistrict #LadyBower to #LostLad and back

071

Prof Amanda J Farrin @amandafarrin.bsky.social · 26/12/2024

Happy Boxing Day from a very sunny Yorkshire 😎🎄 Perfect temperature inversion around #EmleyMoorMast

050

Reposted by Prof Amanda J Farrin

Prof Nisreen Alwan @nisreenalwan.bsky.social · 20/12/2024

With the approaching the start of the holidays please remember that HOW to ‘switch off’ is your thing. There’s no manual. Whatever suits you. Checking emails is not a crime during this time but it’s good practice -if you email back- to schedule sending for when the holiday is over.

35912

Prof Amanda J Farrin @amandafarrin.bsky.social · 19/12/2024

Beautiful day for graduation 🎓 ceremony. So proud of Dr Sadia Ahmed: our 1st @mrcnihrtmrp.bsky.social PhD student to graduate from @leedsctru.bsky.social Grateful for my co-supervisors @suzrich.bsky.social & Andy Clegg And thank you for the beautiful flowers Sadia: but you did the hard work

180

Reposted by Prof Amanda J Farrin

Sue Richards @suzrich.bsky.social · 19/12/2024

I love PhD graduation ceremonies. It is a celebration of watching someone grow in skills and confidence. Congrstulations Dr Sadia Ahmed. @amandafarrin.bsky.social @drandyclegg.bsky.social

0102

Reposted by Prof Amanda J Farrin

Darren Dahly @statsepi.bsky.social · 13/12/2024

-ology = study of methodology = study of method trial methodology = study of the method of clinical trials, including scientific & operational aspects Importantly, a trial methodologist is not necessarily an expert in trial design and analysis

5202

Reposted by Prof Amanda J Farrin

Dr Kelly Lloyd @kellylloyd.bsky.social · 13/12/2024

Interest in learning more about Multiphase Optimisation Strategy (MOST) framework & optimisation trials? New CPD course at University of Leeds on this topic, from 22nd to 24th Jan. The early bird registration deadline is 20th Dec. Read more: medicinehealth.leeds.ac.uk/dir-record/r...

The Multiphase Optimisation Strategy (MOST) framework and optimisation trials.
- Design more effective, affordable, scalable, and efficient complex interventions.
- Utilise novel experimental designs to optimise complex interventions.
- Overcome analysis and delivery challenges.

Led by Dr Rebecca Walwyn and Professor Sam Smith.

In person at the University of Leeds, 22nd to 24th January 2025.

Reserve your place, contact Wendy Hobson w.hobson@leeds.ac.uk

011

Reposted by Prof Amanda J Farrin

Will Cragg @willjcragg.bsky.social · 13/12/2024

Q what should people do in response to the new guidance? 1) be aware of it; 2) read it and consider how you might change what you do; 3) planned/ongoing engagement between WHO and national-level regulators...

132

Reposted by Prof Amanda J Farrin

Will Cragg @willjcragg.bsky.social · 13/12/2024

Vasee Moorthy of WHO talks about the need for proportionate clinical trials training - and not being too led by ICH GCP in all settings/trial types given its origins in the world of drug development

041

Reposted by Prof Amanda J Farrin

Dr Victoria Shepherd @vickylshepherd.bsky.social · 05/12/2024

Recording of our CONSULT training launch webinar now added to the website, alongside details about how to access the e-learning: 🔗https://capacityconsentresearch.com/training Many thanks to the panel @kerryhood.bsky.social @amymrussell.bsky.social @markjayes.bsky.social & others! #Inclusivity

0149

Reposted by Prof Amanda J Farrin

Dr Victoria Shepherd @vickylshepherd.bsky.social · 05/12/2024

📢Now live📢 CONSULT e-learning on trials involving adults with impaired capacity to consent - 4 core modules, case studies, links to resources, free to access, download a certificate on completion 🔗https://www.capacityconsentresearch.com/training @kerryhood.bsky.social @ukctunetwork.bsky.social

Flyer for CONSULT training on trials involving adults lacking capacity to consent

1158

Reposted by Prof Amanda J Farrin

Bethan Copsey @bethancopsey.bsky.social · 05/12/2024

Innovative trials in stroke showcased by @amandafarrin.bsky.social today at #UKSF24

Slide on master protocols presented by Amanda Farrin at the UK stroke forum

141

Reposted by Prof Amanda J Farrin

Bethan Copsey @bethancopsey.bsky.social · 05/12/2024

Promoting hybrid and remote de-centralised elements and outcome selection for platform trials

101

Reposted by Prof Amanda J Farrin

Bethan Copsey @bethancopsey.bsky.social · 05/12/2024

If you're interested in how to measure psychological problems after stroke, please consider filling out our quick survey linktr.ee/leeds_ctru?u... @leedsctru.bsky.social

linktr.ee

Leeds CTRU | Linktree

Linktree. Make your link do more.

001

Reposted by Prof Amanda J Farrin

Louisa Burton @louisabu.bsky.social · 05/12/2024

Looking for people to join our stakeholder group to develop a core outcomes set for trials of interventions designed to treat/prevent psychological problems post-stroke! You may have spotted this slide in @amandafarrin.bsky.social's talk at #uksf24 this morning...

142

Reposted by Prof Amanda J Farrin

Lisa Kidd @lisakidd22.bsky.social · 05/12/2024

Prof Amanda Farrin on the future of trial design & need for platform designs; faster, cheaper, sooner evidence available for practice. Challenging design but very much needed across acute and life after stroke #uksf24 @amandafarrin.bsky.social

093

Reposted by Prof Amanda J Farrin

Vicki Goodwin MBE @vickigphysio.bsky.social · 04/12/2024

Come and do a Dunhill Medical Trust #PhD with me and @jufrost.bsky.social looking at #CGA for people with #heartfailure and #frailty as part of the @nihr.bsky.social funded CHART trial and #processevaluation www.exeter.ac.uk/study/fundin...

exeter.ac.uk

Award details | Funding and scholarships for students | University of Exeter

146

Prof Amanda J Farrin @amandafarrin.bsky.social · 04/12/2024

And we're off. @lisakidd22.bsky.social welcoming us all to #UKSF24. Looking forward to 2 days of all things stroke-related

170

Prof Amanda J Farrin @amandafarrin.bsky.social · 03/12/2024

On my way to #UKSF2024 🙂 @bethancopsey.bsky.social & I are hosting a Table in the Research World Cafe at 12 noon. Come and tell us about the opportunities & challenges for #ClinicalTrials & how the @thestrokeassoc.bsky.social research strategy can support more trials in the future #HaveYourSay

072

Reposted by Prof Amanda J Farrin

Louisa Burton @louisabu.bsky.social · 03/12/2024

First up on my #uksf24 agenda for today is co-hosting a table @thestrokeassoc.bsky.social's Research World Cafe session! Come and join us - we'd love to hear your thoughts about recruitment and retention and how the Stroke Association might support it #ukstrokeforum2024 @auasresearch.bsky.social

061

Reposted by Prof Amanda J Farrin

Peter Tennant @pwgtennant.bsky.social · 02/12/2024

PLEASE SHARE: Registration is now open for the next Introduction to Causal Inference Course for Health & Social Scientists (7-11 July 2025, Leeds, UK). See more info & register here: www.causal.training Note, we are not planning any other courses until 2027. #CausalIntroCourse #EpiSky #CausalSky

Flyer for the Introduction to Causal Inference Course for Health & Social Scientists, taking place on 7th-11th July 2025

16461

Prof Amanda J Farrin @amandafarrin.bsky.social · 02/12/2024

*Risk-proportionate* trial monitoring: a key element of trial integrity. Helpful 🧵from @marionkcampbell.bsky.social 👇

021