iiinova — where your digital self keeps evolving

Allergy EAACI @allergy-eaaci.bsky.social · 08/10/2026

Epithelial AhR–NKX3-1–Senescence Axis Drives Barrier Function and Inflammation in Allergic Rhinitis. First author: Xuan Yuan; corresponding authors: Zhihai Xie, Peisong Gao 👉 doi.org/10.1111/all.70489 Read more articles 👉 journalallergy.com/Rhinitis-Sinusitis-Upper-Airways #Allergy_journal

This study investigates the role of aryl hydrocarbon receptor (AhR)-associated epithelial signaling and its contribution to #barrierdysfunction and allergic inflammation. Allergic rhinitis nasal epithelium exhibits increased AhR activity associated with senescence-related transcriptional programs and senescence-associated secretory phenotype (SASP) inflammatory signals. AhR deficiency and CC10-lineage-enriched p16 deletion attenuate epithelial senescence-associated programs, improve barrier integrity, and reduce Type 2 inflammation in vivo. NKX3-1 contributes to AhR-linked epithelial cell-cycle arrest and senescence-associated responses, while curcumin attenuates allergen-induced senescence-associated phenotypes.

000

Allergy EAACI @allergy-eaaci.bsky.social · 08/10/2026

Much as the #zebrafish (Danio rerio) on this issue's cover lives in constant exchange with its surroundings, the #epithelial #barrier functions less as a passive wall than as a dynamic interface that senses external exposure and translates it into immune and microbial change.

020

Allergy EAACI @allergy-eaaci.bsky.social · 06/10/2026

Open Access: Initial OX40–OX40L Signaling Promotes a Skin-Resident Memory T-Cell Reservoir in Atopic Dermatitis. First author: Takayoshi Komatsu-Fujii; corresponding authors: Ryota Asahina, Toshiaki Kogame, Kenji Kabashima Read the article: doi.org/10.1111/all.70493 #Allergy_journal

Allergy EAACI @allergy-eaaci.bsky.social · 05/10/2026

Open Access: Revisiting Platelet-Activating Factor in Asthma: An Exploratory Metabolomics Analysis of PAF C-18:1 and Type 2 Inflammation. Noeul Kang, Young Jin Pyung, Deog Kyeom Kim, Cheol-Heui Yun, Hyun Woo Lee 👉 doi.org/10.1111/all.70499 #Allergy_journal journalallergy.com

Kang and Pyung et al., investigate type 2 inflammation mediated by various platelet-activating factors (PAF) in asthma and their association with achieving clinical remission. Only PAF C18:1 was found to be inversely associated with T2 inflammatory markers, in contrast to other PAF species detected in the plasma of asthma patients (alkyl-PAF and lyso-PAF). The authors suggest a structure-dependent relationship, whereby the double bond in PAF C18:1 may alter receptor binding or signaling.

Allergy EAACI @allergy-eaaci.bsky.social · 01/10/2026

Open Access: Need to Assess On-Demand Versus Continuous Treatment in Allergic Rhinitis in ARIA-EAACI Guidelines. Corresponding author: Jean Bousquet Read the article here: doi.org/10.1111/all.70498

There is ongoing discussion on whether patients with allergic rhinitis should receive continuous long-term or on-demand treatment. In this Letter, Bousquet et al., point to the low medication adherence observed in MASK-air studies and by physicians with allergic rhinitis. The study recognizes that this data was obtained from selected populations and that there is a need for dedicated guideline recommendations.

Read more articles published in #Allergy on #rhinitis here: journalallergy.com/Rhinitis-Sinusitis-Upper-Airways

#Allergy_journal

Allergy EAACI @allergy-eaaci.bsky.social · 30/09/2026

Open Access: Human IgE Antibodies Recognize the Vicilin and Alpha-Hairpinin Domains of Peanut Allergen Ara h 1. First author: Taylor M. Cosey; corresponding author: Geoffrey A. Mueller Read the article here: doi.org/10.1111/all.70495

The ɑ-hairpinin of Ara h 1 contains a dominant epitope that is both frequently recognized and blocks a majority of the IgE against this domain. Including this region in tests may improve diagnosis of peanut allergy. The trimeric structure of the vicilin region explains the ability of Ara h 1 to induce anaphylaxis with a single antibody.

Read more articles published in #Allergy on #foodallergy here: journalallergy.com/Food-Allergy-and-Gastrointestinal-Disease
#Allergy_journal

Allergy EAACI @allergy-eaaci.bsky.social · 28/09/2026

Open Access: Pathways of Epithelial Barrier Breakdown and Remodeling in Esophageal Organoids by Commonly Used Surfactants. First author: Ozge Ardicli; corresponding author: Willem van de Veen Read the article here: doi.org/10.1111/all.70490 #Allergy_journal journalallergy.com

000

Allergy EAACI @allergy-eaaci.bsky.social · 28/09/2026

Open Access: Targeting Airway Remodeling in Severe Asthma: Is There a Window of Opportunity for Biologic Therapy Predicting Effects Using Causal Artificial Intelligence? Sebastiano Gangemi, Sara Manti, Johann Christian Virchow, Giorgio Walter Canonica 👉 doi.org/10.1111/all.70468

Gangemi et al., discuss a potential time-sensitive “window of opportunity” for optimized biological therapy to mitigate structural airway remodelling, a common feature of asthma progression. The review article provides a framework for linking pathophysiological mechanisms of asthma, biological targets, longitudinal clinical measurements, and the integration of AI methods.

Read more articles published in #Allergy on #biologics here: journalallergy.com/Allergen-Specific-Immunotherapy
#Allergy_journal

000

Allergy EAACI @allergy-eaaci.bsky.social · 25/09/2026

Impaired Clearance of Neutrophil Extracellular Traps in Stevens–Johnson Syndrome/Toxic Epidermal Necrolysis. Corresponding author: Manao Kinoshita 👉 doi.org/10.1111/all.70507 Read more articles here: journalallergy.com/Drug-Insect-Anaphylaxis #Allergy_journal

Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a rare, albeit life-threatening, adverse skin reaction to certain medications. Kinoshita et al. demonstrate that neutrophil extracellular trap (NET) degradation is impaired in SJS/TEN patients due to DNase 1 dysfunction, as patients were observed to exhibit significantly reduced DNase 1 activity and levels. The NET accumulation is further aggravated by inhibition of DNase 1 by G-actin released from necroptotic keratinocytes.

Allergy EAACI @allergy-eaaci.bsky.social · 24/09/2026

A Strong Proposal for the Reasons of Pandemic Increase in Food Allergies Could common food emulsifiers affect intestinal barrier integrity and IgE immune responses? Read the open-access article: doi.org/10.1111/all.70473 @epithelial-barrier.bsky.social #Allergy_journal journalallergy.com

In this new study, SIAF researchers and their international collaborators investigated soy lecithin and DATEM, two widely used emulsifiers found in processed foods, including some peanut butters.

Using human gut-on-a-chip and adult stem cell-derived colon organoid-on-a-chip models, together with human immune cells and mouse models, the researchers found that both emulsifiers:
🔹 Disrupted intestinal epithelial barrier integrity
🔹 Activated pro-inflammatory pathways, including TNF and NF-κB signalling
🔹 Induced local and systemic inflammatory responses
🔹 Stimulated particularly IgEantibody responses

Soy lecithin additionally induced oxidative stress and increased IgE levels in mice, while DATEM enhanced IL-4-induced IgE production in human peripheral blood mononuclear cells.

These findings support the Epithelial Barrier Theory and highlight the need to consider barrier dysfunction and low-grade immune activation when evaluating the biological effects of commonly used food additives. Further studies are needed to determine their long-term effects in humans.

Congratulations to the entire research team on this publication!

131

Allergy EAACI @allergy-eaaci.bsky.social · 23/09/2026

Open Access: The External Exposome and Food Allergy: How Environmental Exposures Shape Disease Risk. First author: Johanna M. Smeekens; corresponding author: Timothy P. Moran 👉 doi.org/10.1111/all.70501 #Allergy_journal journalallergy.com/Food-Allergy-and-Gastrointestinal-Disease

With over 150 references, this review article provides an overview of the most important environmental exposures affecting food allergy. It includes a discussion of environmental food exposures via non-oral routes, microbial exposures, air pollution, industrial chemicals, and nutrition.

000

Allergy EAACI @allergy-eaaci.bsky.social · 23/09/2026

Open Access: Allergen Protease Act d 1 Induces TLR4-Dependent Inflammation via Ectodomain Cleavage. Milena Zlatanova, Iva Hafner-Bratkovič, Marija Gavrović-Jankulović Read the article here: doi.org/10.1111/all.70456

Using TLR4 knockout bone marrow-derived macrophages and HEK293 cells transfected with TLR4, Zlatanova et al., demonstrate that the enzymatic function of Act d 1 is essential for TLR4 activation. The authors propose an alternative mechanism of receptor activation where Act d 1 cleaves the TLR4 ectodomain, thereby removing the domain responsible for maintaining TLR4 in an inactive state in the absence of its ligand.

Read more articles published in #Allergy on basic and translational #immunology here: journalallergy.com/Basic-and-Translational
#Allergy_journal

000

Allergy EAACI @allergy-eaaci.bsky.social · 21/09/2026

Open Access: Efficacy and Safety of Intralymphatic Immunotherapy With Grass Allergoid and Microcrystalline Tyrosine: A Double-Blind Randomised Placebo-Controlled Trial. First authorLara Šošić; corresponding author: Pål Johansen Read the article here: doi.org/10.1111/all.70463

This is the first randomised placebo-controlled trial of intralymphatic #immunotherapy using a microcrystalline tyrosine-adjuvanted grass pollen allergoid. Three ultrasound-guided intralymphatic immunotherapy (ILIT) injections were well tolerated and reduced combined symptom-medication scores compared with placebo. The findings support further optimisation and clinical development of allergoid-based ILIT for #grasspollen allergy.

#Allergy_journal
Read more articles published in #Allergy on allergen immunotherapy here: journalallergy.com/Allergen-Specific-Immunotherapy

Allergy EAACI @allergy-eaaci.bsky.social · 18/09/2026

Efficacy of Full and Limited Endoscopic Sinus Surgery in Chronic #Rhinosinusitis With Nasal Polyps: A Randomised Controlled Trial. First author: Paula Virkkula 👉 doi.org/10.1111/all.70438 #Allergy_journal Read more articles: journalallergy.com/Rhinitis-Sinusitis-Upper-Airways

Both Full and Limited FESS result in clinically meaningful relief of disease-specific health-related quality of life (HRQoL) and nasal breathing, effectively improving nasal symptoms and sleep disturbance in chronic rhinosinusitis with nasal polyps (#CRSwNP) patients. Clinically meaningful differences in decreases of SNOT-22 scores (22-item Sino-nasal Outcome Test) between the groups were not found at 12- and 24–month follow-up. Differences in improvement of anosmia, and decreases in polyp load were seen between the groups.

Allergy EAACI @allergy-eaaci.bsky.social · 17/09/2026

Tezepelumab Reverses TSLP-Driven Immunometabolic Rewiring in Human cDC2s Underlying Pathogenic Th2 and Dysfunctional Treg Responses. First author: Leticia Martín-Cruz; corresponding author: Oscar Palomares 🌟 doi.org/10.1111/all.70470

This study aimed to determine whether thymic stromal lymphopoietin (TSLP) induces a pathogenic immunometabolic program in human type 2 conventional dendritic cells (cDC2s) and whether tezepelumab can directly reverse this process. TSLP rewires human cDC2 metabolism by increasing both glycolysis and mitochondrial oxidative phosphorylation. This metabolic shift drives a pro-type 2 phenotype required to generate pathogenic Th2 cells and functionally impaired FOXP3+ Tregs. Tezepelumab effectively restores normal metabolic and functional properties in cDC2s, inhibiting Th2 polarization and rescuing Treg function.

#Allergy_journal
Read more articles published in #Allergy on basic and clinical immunology here: https://journalallergy.com/Basic-and-Translational

Allergy EAACI @allergy-eaaci.bsky.social · 16/09/2026

Respiratory inflammation spans a spectrum of upper and lower airway diseases, asthma, chronic rhinosinusitis, allergic and non-allergic rhinitis, and COPD, unified by overlapping type 2 and non-type 2 inflammatory mechanisms.

022

Allergy EAACI @allergy-eaaci.bsky.social · 14/09/2026

K. Hosoki, A. Sur, A. Govindhan, et al., “T Cell-Intrinsic NEIL2 Restrains Th2 Allergic Inflammation by Regulating Chromatin Accessibility,” 👉 doi.org/10.1111/all.70500 #Allergy_journal Watch videos of recent discoveries: journalallergy.com and youtube.com/@Allergy-TV www.youtube.com/watch?v=5srA...

T Cell-Intrinsic NEIL2 Restrains Th2 Allergic Inflammation by Regulating Chromatin Accessibility

Type 2 Immunity & Allergy Lab @jimenez-saiz-lab.bsky.social · 14/09/2026

000

Reposted by Allergy EAACI

Our @allergy-eaaci.bsky.social review explores the roles of #T2Immunity in #barrier defense, #metabolism, #vascular & #neuroimmune regulation, #tissue repair and #homeostasis; and the implications of broadly suppressing these pathways. onlinelibrary.wiley.com/doi/10.1111/...

onlinelibrary.wiley.com

131

Allergy EAACI @allergy-eaaci.bsky.social · 14/09/2026

#Atopicdermatitis, also known as eczematous dermatitis and atopic #eczema, is a skin disease characterized by extremely itchy and irritated skin that poses a great burden to the patient.

1. Fehr D, Flack N, Masenga G, et al. Dietary Habits and Atopic Dermatitis Significantly Influence the Fecal Microbiome. Allergy.n/a(n/a). https://doi.org/10.1111/all.70459

2. Kim M, Del Duca E, Correa Da Rosa J, et al. Effect of Abrocitinib on the Skin Microbiome in Patients With Moderate-to-Severe Atopic Dermatitis. Allergy.n/a(n/a). https://doi.org/10.1111/all.70467

3. Komatsu-Fujii T, Asahina R, Hasegawa T, et al. Initial OX40–OX40L Signaling Promotes a Skin-Resident Memory T-Cell Reservoir in Atopic Dermatitis. Allergy.n/a(n/a). https://doi.org/10.1111/all.70493

4. Lally JS, Yoshida T, Gao S, et al. Serum-Proteomic Profiling Reveals Distinct Atopic Dermatitis Severity-Linked Signatures. Allergy.n/a(n/a).
https://doi.org/10.1111/all.70464

5. Lee JH, Lim SH, Kook H, et al. Mycosis Fungoides-Like Atopic Dermatitis Represents a Th22-Dominant Inflammatory Endotype. Allergy.n/a(n/a).
https://doi.org/10.1111/all.70440

6. Bhattacharyya M, Lauffer F, Jargosch M, et al. Skin Lipid-Microbe Interplay Links Staphylococcus hominis to Barrier Control in Adult Atopic Dermatitis. Allergy. 2026;81(2):454-467. https://doi.org/10.1111/all.70028

7. Bieber T, Maintz L, Phad GE, Bruggen MC. From Disease Control to Disease Modification: The Atopic Dermatitis Disease Activity Index. Allergy. 2026;81(2):577-579. https://doi.org/10.1111/all.70036

8. Czarnowicki T, Sugita K, Yiu Z, et al. Divergent Paths: A Comprehensive Review of Mechanisms and Clinical Implications in Atopic Dermatitis and Psoriasis. Allergy. 2026;81(7):2309-2324. https://doi.org/10.1111/all.70347

9. D'Avino P, Kim J, Li M, et al. Distinct Roles of IL-4, IL-13, and IL-22 in Human Skin Barrier Dysfunction and Atopic Dermatitis. Allergy. 2026;81(2):480-497. https://doi.org/10.1111/all.70060

10. de Bruin-Weller MS, Boesjes CM, Achten RA, et al. Biologics to Treat Atopic Dermatitis: Effectiveness, Safety, and Future Directions. Allergy. 2026;81(2):326-344. https://doi.org/10.1111/all.70061

#Allergy_journal

Allergy EAACI @allergy-eaaci.bsky.social · 13/09/2026

Open access: Serum‐Proteomic Profiling Reveals Distinct #AtopicDermatitis Severity‐Linked Signatures. First author: Jag S. Lally; corresponding author: Anna De Benedetto 👉 doi.org/10.1111/all.70464 #Allergy_journal More articles 👉 journalallergy.com/Atopic_Dermatitis_Urticaria_and_Skin_Disease

This study aimed to identify a set of serum biomarkers that robustly distinguish prespecified severe from mild atopic dermatitis groups. Serum proteomic profiling distinguishes severe from mild atopic dermatitis, revealing an epithelial-enriched severity footprint linked to lactate dehydrogenase (LDH)-associated tissue injury and Th2/Th22 inflammation. Machine learning identified a 9-protein biomarker signature that discriminated severity groups with high cross-validation accuracy (AUC = 0.989).

021

Allergy EAACI @allergy-eaaci.bsky.social · 12/09/2026

M. J. Torres, C. Mayorga, E. J. Phillips, et al., “Nomenclature on Immune-Mediated Drug Reactions: An #EAACI Position Paper,” 👉 doi.org/10.1111/all.70480 #Allergy_journal Watch videos of recent discoveries: journalallergy.com and youtube.com/@Allergy-TV www.youtube.com/watch?v=1LdU...

Nomenclature on Immune-Mediated Drug Reactions: An EAACI Position Paper

Allergy EAACI @allergy-eaaci.bsky.social · 11/09/2026

000

Melittin in AllergoOncology: From Honey Bee Venom to Anti-Cancer Therapeutic Innovation—An #EAACI Position Paper Corresponding author: Teodorikez-Wilfox Jimenez-Rodriguez 👉 doi.org/10.1111/all.70421 #Allergy_journal Read more articles published in #Allergy here: journalallergy.com

With over 100 references, this #EAACI Position Paper reviews the potential of the honey bee venom allergen melittin as a potential candidate for the treatment of cancer. It provides mechanistic insights into its anti-tumor activity across various types of cancer, safety considerations, limitations and advancements.

002

Allergy EAACI @allergy-eaaci.bsky.social · 10/09/2026

D. Ni, G. Pinget, B. Santner-Nanan, et al., “ #Biomarkers Predicting Sustained Unresponsiveness After Oral #Immunotherapy in the OPIA Trial,” 👉 doi.org/10.1111/all.70478 #Allergy_journal Watch more videos👉 journalallergy.com and youtube.com/@Allergy-TV www.youtube.com/watch?v=95lZ...

Biomarkers Predicting Sustained Unresponsiveness After Oral Immunotherapy in the OPIA Trial

Allergy EAACI @allergy-eaaci.bsky.social · 09/09/2026

000

Open Access: Dupilumab in Cholinergic Urticaria: An Exploratory Phase 2 Investigator-Initiated Study. First authors: Annika Gutsche, Weronika Grabowska; corresponding author: Martin Metz 👉 doi.org/10.1111/all.70454 #Allergy_journal

This study evaluates the effectiveness and safety of #dupilumab, an IL-4Rα inhibitor, for the treatment of cholinergic urticaria (ChoIU), a rare condition manifested as pruritic wheals triggered by sweating and increases in body temperature. In a phase 2 randomized, double-blind trial of 42 adults with ChoIU, no significant difference was observed between patients treated with dupilumab and those treated with placebo at weeks 16 and 32.

#Allergy_journal
Read more articles published in #Allergy on #urticaria here: journalallergy.com/Atopic_Dermatitis_Urticaria_and_Skin_Disease

000

Reposted by Allergy EAACI

epithelial-barrier.bsky.social @epithelial-barrier.bsky.social · 08/09/2026

Zhao, B., Babayev, H., et al., Monosodium Glutamate Induces Cellular Stress, Endoplasmic Reticulum Stress, Mitochondrial Dysfunction, and Cell Death in Intestinal Epithelial Cells. 👉 doi.org/10.1111/all.70007 epithelialbarriertheory.com #EpithelialBarrierTheory @allergy-eaaci.bsky.social

012

Allergy EAACI @allergy-eaaci.bsky.social · 08/09/2026

T. Komatsu-Fujii, R. Asahina, T. Hasegawa, et al., “ Initial OX40–OX40L Signaling Promotes a Skin-Resident Memory T-Cell Reservoir in #AtopicDermatitis,” 👉 doi.org/10.1111/all.70493 #Allergy_journal Watch more videos 👉 journalallergy.com and youtube.com/@Allergy-TV www.youtube.com/watch?v=jRP3...

Initial OX40–OX40L Signaling Promotes a Skin-Resident Memory T-Cell Reservoir in Atopic Dermatitis

Allergy EAACI @allergy-eaaci.bsky.social · 06/09/2026

Effect of Abrocitinib on the Skin Microbiome in Patients with Moderate‐to‐Severe Atopic Dermatitis. First author: Madeline Kim; corresponding author: Emma Guttman-Yassky 👉 doi.org/10.1111/all.70467 Watch the video abstract here: youtube.com/watch?v=03MspazqW0E #Allergy_journal

Atopic dermatitis (AD) is characterized by microbial dysbiosis. This study aimed to evaluate the effects of abrocitinib, a JAK1-selective inhibitor, on the skin microbiome and its potential associations with clinical outcomes in patients with AD. Abrocitinib treatment was associated with increased skin microbial diversity and decreased Staphylococcus aureus burden over 12 weeks that corresponded with efficacy improvements. %BSA, percentage of body surface affected; AD, atopic dermatitis; EASI, Eczema Area and Severity Index; FCH, fold change; IGA, Investigator's Global Assessment; Jak1, Janus kinase 1; PP-NRS, Peak Pruritus Numerical Rating Scale.

Read more articles published in #Allergy here: journalallergy.com/

122

Allergy EAACI @allergy-eaaci.bsky.social · 05/09/2026

Simultaneous Dual Type 2 Biologic Therapy Improves Sinonasal Outcomes in Selected Patients With Chronic Rhinosinusitis With Nasal Polyps. Corresponding author: Friederike Bärhold Read the article here: doi.org/10.1111/all.70452 #Allergy_journal

Data from 34 patients with severe chronic rhinosinusitis with nasal polyps (CRSwNP) were collected retrospectively from 6 European study centers. Patients showed high type-2 comorbidity burden, supporting dual therapy as a potential option in complex type-2 diseases. Significant improvements were observed in SNOT-22, olfactory function, and nasal polyp score after 6 months compared to baseline with single biologic therapy.

Read more articles published in #Allergy on #rhinitis here: journalallergy.com/Rhinitis-Sinusitis-Upper-Airways

Allergy EAACI @allergy-eaaci.bsky.social · 04/09/2026

Plasma Metabolomes Identify Distinct #Asthma Metabotypes: Findings From the COREA Cohort. First authors: Woori Chae, Jin An; corresponding authors: Joo-Youn Cho, Tae-Bum Kim 👉 doi.org/10.1111/all.70469 #Allergy_journal Read more articles 👉 journalallergy.com/Asthma-Lower-Airways

This study aimed to identify metabolic subgroups (metabotypes) of adult #asthma using plasma metabolomics, with potential implications for personalized treatment. Four metabotypes with distinct lipid-class signatures were identified. Group 1 had elevated ether-linked phosphatidylcholines with young, female-predominant early onset; Group 2 showed elevated lyso-phosphatidylcholines and altered amino acid metabolism; Group 3 exhibited reduced sphingomyelins and phosphatidylcholines in middle-aged, non-obese patients; and Group 4 demonstrated elevated triacylglycerols and diacylglycerols with the highest body mass index.

022

Allergy EAACI @allergy-eaaci.bsky.social · 03/09/2026

Open access: Distinct Gene Expression Profiles of Ara h 2‐Specific B Cells in Desensitization and Tolerance During Peanut Oral Immunotherapy. First author: Stephan R. Schneider; corresponding author: Mübeccel Akdis Read the article here: doi.org/10.1111/all.70472

Gene expression of Ara h 2-specific B cells over the course of the peanut oral #immunotherapy (OIT). Isotype of allergen-specific B cells changes through OIT towards IgG4. Peanut OIT changes the gene expression of allergen-specific memory B cells. OIT patients showed increased gene expression for regulatory B cells and immune regulation. Desensitized patients had upregulated antiviral genes compared to tolerant patients.

#Allergy_journal
Read more articles published in #Allergy on #foodallergy here: journalallergy.com/Food-Allergy-and-Gastrointestinal-Disease

Allergy EAACI @allergy-eaaci.bsky.social · 02/09/2026

Mycosis Fungoides‐Like Atopic Dermatitis Represents a Th22‐Dominant Inflammatory Endotype. First author: Jung Ho Lee; corresponding authors: Hyun Je Kim and Jiyoung Ahn Read the article here: doi.org/10.1111/all.70440

$Single-cell transcriptomic, T-cell receptor, and spatial analyses distinguished mycosis fungoides-like atopic dermatitis (mfAD) from classic mycosis fungoides (MF) and atopic dermatitis (AD). mfAD showed oligoclonal T-cell expansion with chromosomal stability, enriched CD4/CD8 tissue-resident memory T cells, and a dominant Th22/IL-13 inflammatory signature. The findings clarify mechanisms of #dupilumab refractoriness and highlight JAK inhibition as a potential therapeutic strategy in mfAD. #Allergy_journal Read more articles published in #Allergy on #atopicdermatitis here: journalallergy.com/Atopic_Dermatitis_Urticaria_and_Skin_Disease$

Allergy EAACI @allergy-eaaci.bsky.social · 01/09/2026

Open access: Common Food Emulsifiers Impair Epithelial Barrier Integrity and Trigger Pro-Inflammatory Responses and IgE Production. First author: Duygu Yazici; corresponding author: Cezmi A. Akdis 👉 doi.org/10.1111/all.70473 #Allergy_journal

Soy lecithin (E322) and diacetyl tartaric acid ester of mono- and diglycerides (DATEM, E472e), the two commonly used food emulsifiers introduced into many foods including peanut butter and puffed bread, in the 2000s, impair intestinal epithelial barrier integrity in human gut-on-a-chip and induced pluripotent stem cell colon organoid models. Both emulsifiers activate NF-κB/TNF-driven inflammatory pathways and induce stress responses and apoptosis in epithelial cells, with soy lecithin additionally triggering oxidative stress and suppressing aryl hydrocarbon signaling in gut epithelial cells. Oral exposure to emulsifiers within the range of daily doses induces local gastrointestinal and systemic inflammatory responses in mice and increases IgE and IgG responses, suggesting a role in the development of allergies.

020

Allergy EAACI @allergy-eaaci.bsky.social · 30/08/2026

A. Barbaud, L. H. Garvey, E. Phillips, et al., “Updated #EAACI Statement on Drug Hypersensitivity Skin Testing: Methodology and Non-Irritative Concentrations,” Allergy (2026), 👉 doi.org/10.1111/all.70466 #Allergy_journal Watch videos 👉 youtube.com/@Allergy-TV www.youtube.com/watch?v=3dYo...

Updated EAACI Statement on Drug Hypersensitivity Skin Testing

Allergy EAACI @allergy-eaaci.bsky.social · 29/08/2026

Open access: m6A-Related Regulation of Ferroptosis Contributes to Nasal Epithelial Barrier Dysfunction in Allergic Rhinitis. First author: Zehua Lin; corresponding authors: Zuhong He, Xiong Chen Read the article here: doi.org/10.1111/all.70476 #Allergy_journal

This study uses human nasal epithelial cells and BALB/c mice to evaluate the role and molecular mechanism of ferroptosis in house dust mite (HDM)-induced allergic #rhinitis (AR), focusing on ferroptosis-related responses and nasal #epithelialbarrier disruption. HDM exposure induces lipid peroxidation-driven ferroptosis and epithelial barrier disruption. GPX4 protects against this damage, whereas GAS1 promotes ferroptosis by suppressing GPX4, a mechanism validated in GAS1-knockdown mice.

Read more articles published in #Allergy on #rhinitis here: journalallergy.com/Rhinitis-Sinusitis-Upper-Airways

002

Allergy EAACI @allergy-eaaci.bsky.social · 28/08/2026

Open Access: Postcode-Level Variation and Environmental Determinants of Respiratory Allergies in a Large German Cohort. First author: Trang Dao-Siebel; corresponding author: Evelyn Lamy 👉 doi.org/10.1111/all.70406 Read more articles 👉 journalallergy.com/climate-change #allergy_journal

Young children (0–9 years) and residents of urban areas appeared particularly vulnerable to respiratory allergy development and exacerbation. Incidence showed nonlinear associations with particular matter 10 (PM10) PM2.5, temperature, and alder/birch pollen, while dispensed prescribed medication rate showed similar patterns, except for NO2 and the interaction O3*NO2. Combined reductions in PM10 exposure and alder pollen may have the greatest potential to reduce respiratory allergy burden.

011

Allergy EAACI @allergy-eaaci.bsky.social · 26/08/2026

Open Access: Differential Roles for IL-4Rα and IL-13Rα1 in Immune Cell Infiltration and Epithelial Remodeling in Experimental Eosinophilic Gastritis. First author: Anish Dsilva; corresponding author: Ariel Munitz 👉 doi.org/10.1111/all.70420 #Allergy_journal

This study described the development of an experimental model for eosinophilic gastritis (EoG). Experimental EoG recapitulates histopathological features of human disease, including foveolar elongation, fibrosis, eosinophilia, mastocytosis and shared transcriptional programs. Eosinophilia and mastocytosis were regulated by IL-4Rα, whereas mucosal thickening and foveolar elongation were regulated by IL-4Rα and IL-13Rα1.

Allergy EAACI @allergy-eaaci.bsky.social · 25/08/2026

T.-H. Chen, C. C. K. Chou, and B.-L. Chiang, “ Gut Microbiota Signatures Reflect Particulate Matter 2.5-Exacerbated #Asthma in a Murine Model,” 👉 doi.org/10.1111/all.70485 #Allergy_journal Watch more videos👉 journalallergy.com and youtube.com/@Allergy-TV www.youtube.com/watch?v=FPXq...

Gut Microbiota Signatures Reflect Particulate Matter 2.5-Exacerbated Asthma in a Murine Model

Allergy EAACI @allergy-eaaci.bsky.social · 24/08/2026

000

Open Access: Clinical Features of Cellular Senescence Pathways in Severe Asthma. First author: Woo-Jung Song; corresponding author: Kian Fan Chung 👉 doi.org/10.1111/all.70416 #Allergy_journal Read more articles published in #Allergy on #asthma here: journalallergy.com/Asthma-Lower-Airways

In bronchial biopsies, senescence-associated secretory phenotype (SASP) and p53 pathway enrichment scores are elevated in severe asthma versus non-severe asthma and healthy controls. SASP enrichment is validated in the independent Newcastle severe asthma cohort (NOVA). SASP enrichment is also elevated in nasal brushings of participants with nasal polyps, independently of asthma status. Senescence pathway enrichment associates with exacerbations, daily oral corticosteroid (OCS), lower post-bronchodilator (post-BD) forced expiratory volume in 1 s (FEV1%) and macrophage/oxidative phosphorylation (OXPHOS) signatures, but not with Th2/eosinophil signatures, supporting a non-T2 mechanism.

Allergy EAACI @allergy-eaaci.bsky.social · 23/08/2026

M. B. Svendsen, T. Sultan, A. Kjellberg, et al., “Pathogenic Airway Bacteria and Local Immune Responses During Early-Life Asthma-Like Episodes,” 👉 doi.org/10.1111/all.70481 #Allergy_journal Watch more videos journalallergy.com and youtube.com/@Allergy-TV www.youtube.com/watch?v=4qgX...

Pathogenic Airway Bacteria and Local Immune Responses During Early-Life Asthma-Like Episodes

Allergy EAACI @allergy-eaaci.bsky.social · 22/08/2026

000

Open Access: Algorithms in Allergy: Diagnosis of Concomitant Inducible Laryngeal Obstruction in Adults With Asthma. Andrew P. Hearn, Claire Slinger, Jennifer M. Butler, Jemma Haines, James Hull, Stephen J. Fowler Read the article here: doi.org/10.1111/all.70425

Inducible laryngeal obstruction (ILO) and #asthma have distinct pathophysiological mechanisms and present different clinical symptoms. This article outlines clinical features to distinguish between the two and a medical diagnostic algorithm for identifying ILO in patients with asthma. It further summarizes treatment options for confirmed cases.

#Allergy_journal
Read other medical algorithms published in #Allergy here: journalallergy.com/Asthma-Lower-Airways

Allergy EAACI @allergy-eaaci.bsky.social · 21/08/2026

M. Czarnobilska, M. Bulanda, E. Czarnobilska, et al.“Influence of Environmental Pollution on Basophil Reactivity to Birch Pollen Allergens in Atopic and Non-Atopic Subjects,” 👉 doi.org/10.1111/all.70474 #Allergy_journal Watch more videos👉 youtube.com/@Allergy-TV www.youtube.com/watch?v=ri9-...

Environmental Pollution on Basophil Reactivity to Birch Pollen in Atopic and Non-Atopic Subjects

Allergy EAACI @allergy-eaaci.bsky.social · 20/08/2026

Open Access: Determinants of Poor Health-Related Quality of Life in Patients With Food Allergy. First author: Rosialzira Natasha Vera-Berrios; corresponding author: Montserrat Fernández-Rivas Read the article here: doi.org/10.1111/all.70418

Machine-learning analysis of 502 well-characterised food-allergic patients was used to identify key determinants of poor food allergy-health-related quality of life (FA-HRQL), defined as FAQLQ ≥ 5. The most relevant predictors were adult age, female sex, multiple food allergies, severe reactions, need for urgent care, onset before 18 years, and longer disease duration. Adult women with multiple food allergies showed the poorest FA-HRQL.

#Allergy_journal
Read more articles published in #Allergy on #foodallergy here: journalallergy.com/Food-Allergy-and-Gastrointestinal-Disease

021

Allergy EAACI @allergy-eaaci.bsky.social · 19/08/2026

L. Martín-Cruz, A. de la Rocha-Muñoz, I. M. Peñalver-Fernández, et al.“Tezepelumab Reverses TSLP-Driven Immunometabolic Rewiring in Human cDC2s Underlying Pathogenic Th2 and Dysfunctional Treg Responses,” doi.org/10.1111/all.70470 #Allergy_journal www.youtube.com/watch?v=uzNd...

Tezepelumab Reverses TSLP-Driven Immunometabolic Rewiring in Human cDC2s

APC Microbiome Ireland @apcmicrobiomeirel.bsky.social · 19/08/2026

Reposted by Allergy EAACI

2 reviews in @allergy-eaaci.bsky.social examine iron deficiency in atopic disease & the immune sequence during IgE-mediated food reactions. Group Leader Liam O’Mahony contributed to both. buff.ly/fu6r6Qh buff.ly/FJbWULo #Allergy #Immunology #FoodAllergy #AtopicDisease @uccmicrobiology.bsky.social

213

Allergy EAACI @allergy-eaaci.bsky.social · 18/08/2026

Open Access: Distinct Skin Penetration and Immune Responses to Ionic and Nanoparticulate Cobalt in Allergic Contact Dermatitis. P. Werner, M. Schaier, G. Braun, A. Julander, K. Midander, M. Isaksson, G. Koellensperger, L. Wisgrill, N. Fyhrquist Read the article here: doi.org/10.1111/all.70422

Cobalt chloride (CoCl2) and cobalt nanoparticles (CoNPs) induce a shared, severity-dependent inflammatory response in cobalt-sensitized skin characterized by activation of interferon signaling, inflammatory pathways (TNF/NF-κβ, IL6-STAT3), apoptosis/unfolded protein response (UPR), cell cycle programs, and glycolysis. Despite comparable nominal exposure, the two cobalt forms exhibit distinct tissue distribution: CoCl2 penetrates deeply and accumulates intracellularly across epidermal and dermal compartments, whereas CoNPs are largely retained in the stratum corneum. Direct comparison reveals divergent transcriptional programs, with CoCl2 preferentially inducing interferon and antiviral responses (e.g., IRF7), and CoNPs promoting keratinization and epithelial differentiation (e.g., KRT25). Together, these findings demonstrate that cobalt speciation and penetration depth shape tissue exposure and downstream immune responses in allergic contact dermatitis.

Read more articles published in #Allergy on #atopicdermatitis here: journalallergy.com/Atopic_Dermatitis_Urticaria_and_Skin_Disease

011

Allergy EAACI @allergy-eaaci.bsky.social · 17/08/2026

D. Villalta, G. Marcassa, G. Cusa, et al., “Hazelnut and Walnut Vicilins in Tree Nut Allergy: Co-Sensitization Patterns and Clinical Severity Associations,” Allergy (2026),👉 doi.org/10.1111/all.70482 #Allergy_journal Watch videos of recent disc www.youtube.com/watch?v=e3KY...

Hazelnut and Walnut Vicilins in Tree Nut Allergy