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Alex Matia

@alexmatia.bsky.social
114 followers 243 following 27 posts

Postdoc fellow investigating the mechanisms of viral neuropathogenesis @StanfordMed and @CZBiohub | PhD in Poxvirus ☣️ @CSIC #viromics #poxrocks #flavis

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Alex Matia @alexmatia.bsky.social · 17h
Flu is back: #CDC #InfluenzaVirus
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Alex Matia @alexmatia.bsky.social · 24/09/2026
🚨 New preprint alert!! 🧠🦟🦠 What does West Nile virus actually do to a human neuron? We built an hiPSC-neuron platform, mapped WNV infection by temporal proteomics + RNA-seq, and found LA24, a new strain that is attenuated in neurons. 📄 www.biorxiv.org/content/10.6... 🧵👇
biorxiv.org
Human iPSC-derived neurons identify West Nile virus neuropathogenesis signatures and reveal strain-dependent neuroattenuation
West Nile virus (WNV) is one of the leading causes of arthropod-transmitted encephalitis in the world, yet its effects on neurons, the principal target of WNV in the brain, remain poorly defined. Here...
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bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 24/09/2026
Human iPSC-derived neurons identify West Nile virus neuropathogenesis signatures and reveal strain-dependent neuroattenuation www.biorxiv.org/content/10.64898/20…
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Alex Matia @alexmatia.bsky.social · 24/09/2026
🚨 New preprint alert!! 🧠🦟🦠 What does West Nile virus actually do to a human neuron? We built an hiPSC-neuron platform, mapped WNV infection by temporal proteomics + RNA-seq, and found LA24, a new strain that is attenuated in neurons. 📄 www.biorxiv.org/content/10.6... 🧵👇
biorxiv.org
Human iPSC-derived neurons identify West Nile virus neuropathogenesis signatures and reveal strain-dependent neuroattenuation
West Nile virus (WNV) is one of the leading causes of arthropod-transmitted encephalitis in the world, yet its effects on neurons, the principal target of WNV in the brain, remain poorly defined. Here...
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European Centre for Disease Prevention and Control @ecdc.europa.eu · 20/08/2026
Watch the full #ECDCOnAir episode for more on dengue, chikungunya, West Nile virus and Europe’s changing mosquito landscape on: 🎧 Spotify: bit.ly/ECDConAir77 📺 YouTube: youtu.be/PCSg7UjHdoY 🎶 Soundcloud: soundcloud.com/ecdc_eu/ecdc... more on #WorldMosquitoDay: www.ecdc.europa.eu/en/news-even...
ecdc.europa.eu
World Mosquito Day 2026: Europe must upgrade control tools as disease risks rise
Europe needs to improve its preparedness and control efforts as the risk of mosquito-borne diseases increases, with West Nile virus (WNV) continuing to spread to new regions and invasive mosquito spec...
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California Department of Public Health @capublichealth.bsky.social · 20/08/2026
West Nile virus activity is at a five-year high in California. CDPH urges Californians to take steps to protect against mosquito bites as hot temperatures contribute to more mosquitoes and increased risk of transmission. Learn more: www.cdph.ca.gov/Programs/OPA... [1/4]
A person sprays insect repellent onto their arm outdoors. Text on the image reads, “Prevent mosquito bites. Protect yourself and loved ones from West Nile virus.” The CDPH logo appears on the right side.
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UC Berkeley @ucberkeleyofficial.bsky.social · 04/08/2026
How worried should you be about West Nile virus? Berkeley public health professor Dr. Justin Remais discusses how to protect yourself from this mosquito-borne disease, as he notes another sharp rise in California’s West Nile virus activity. bit.ly/4cn0JpV
bit.ly
How worried should you be about West Nile virus?
Dr. Justin Remais of the UC Berkeley School of Public Health on how to protect yourself from this mosquito-borne disease.
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Alex Matia @alexmatia.bsky.social · 05/08/2026
First WNV death in Spain this year: efe.com/andalucia/20... #WestNileVirus
efe.com
Confirman la muerte en Sevilla de un hombre de 82 años por virus del Nilo - EFE
La Consejería de Presidencia, Sanidad y Emergencias de la Junta confirma la muerte en Sevilla de un hombre de 82 años por virus del Nilo.
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Alex Matia @alexmatia.bsky.social · 31/07/2026
Very high WNV activity this year in California 🦟 Take care out there! ...and report dead birds here: westnile.ca.gov
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Nature @nature.com · 29/07/2026
Mosquito-borne diseases are breaking records as climate change and other human influences allow the insects to expand their range go.nature.com/4x6xhMK
go.nature.com
How mosquitoes are conquering the world — in four charts
Mosquito-borne diseases are breaking records as climate change and other human influences allow the insects to expand their range.
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Alex Matia @alexmatia.bsky.social · 10/07/2026
Excited to share our new review! 🎉 Together with @rhuttenhain.bsky.social, we discuss how emerging proteomics approaches are revealing the spatial and temporal organization of the cellular proteome. Great fun writing this together! www.sciencedirect.com/science/arti...
sciencedirect.com
Resolving cellular signaling in space and time: From organelle proteomics to spatial phosphoproteomics
Cellular signaling is inherently organized in space and time, requiring coordinated control of protein localization, molecular interactions, and enzym…
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Ruth Huttenhain @rhuttenhain.bsky.social · 30/06/2026
Preprint out! We optimized synchro-PASEF for phosphoproteomics & found equivalent biological insights to dia-PASEF despite fewer total IDs. Practical tip: apply retention time summation factor 2 to any PASEF phosphoproteomics data—you'll gain IDs and precision. www.biorxiv.org/content/10.6...
biorxiv.org
Systematic optimization and benchmarking of synchro-PASEF for high-throughput phosphoproteome profiling
High-throughput data-independent acquisition (DIA) workflows paired with short chromatographic separations are increasingly adopted for systems biology and clinical proteomics. However, narrower peak ...
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bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 10/04/2026
V-SWITCH: A single-vector OFF-to-ON fluorescent reporter of live RNA virus infections www.biorxiv.org/content/10.64898/20…
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Alex Matia @alexmatia.bsky.social · 02/04/2026
Not the best way to start a Thursday in the Bay Area
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PLOS Biology @plosbiology.org · 16/02/2026
Despite decades of intensive research, current approaches to treating #NeurodegenerativeDiseases only slow down the seemingly inevitable. Could recent data associating #vaccines with reduced risk of #dementia offer an unexpected beacon of hope?🧪 @sparrerlab.bsky.social
plos.io
Could targeting viruses be a new hope against neurodegenerative diseases?
Current therapies for neurodegenerative diseases largely manage symptoms and only modestly slow progression. This Perspective highlights emerging evidence that vaccines and antivirals may lower…
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bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 04/02/2026
Not all West Nile virus lineages behave alike: vector competence and minimum infectious dose differences between lineages 1 and 2 www.biorxiv.org/content/10.64898/20…
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Miguel Ángel Jiménez-Clavero @virusemergentes.bsky.social · 31/01/2026
NEW PAPER OUT! Pathogenicity assessment of Spanish West Nile virus isolates of lineages 1 and 2 in a Swiss mouse model doi.org/10.1016/j.ve...
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Mari de Sautu @maridesautu.bsky.social · 27/01/2026
Check out our new preprint! We uncover the full molecular mechanism of rotavirus membrane penetration and cytosolic escape using cryo-ET, live-cell imaging, and single-molecule assays. (1/3) 🔗 biorxiv.org/content/10.6...
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Alex Matia @alexmatia.bsky.social · 27/01/2026
Austria, Spain, and several other countries just lost their measles elimination status too.
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European Virus Bioinformatics Center @evbc.bsky.social · 27/01/2026
📢 Abstract submission is now open for ViBioM 2026 in Vilnius!! Share your work and be part of the conference in May! #virology #bioinformatics #ViBioM2026 🎤 Talk Abstract Deadline: 6 March 2026 📜 Poster Title Deadline: 17 April 2026 🔗 evbc.uni-jena.de/events/vibio...
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Alex Matia @alexmatia.bsky.social · 26/01/2026
Sadly, another country is losing its measles elimination status for a virus whose vaccine is highly effective. www.bbc.com/news/article...
bbc.com
UK loses measles elimination status
Decision made after outbreaks in 2024, when there were nearly 3,000 cases in England and Wales.
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European Centre for Disease Prevention and Control @ecdc.europa.eu · 23/01/2026
Weekly respiratory viruses update: - #influenza circulation HIGH, but has peaked - #RSV circulation ELEVATED and increasing and increasing - #SARSCoV2 circulation remains at LOW levels. More info: erviss.org #ERVISS #RespiratoryViruses #IDsky #EpiSky #COVID19
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Mehdi Bouhaddou @doctorbou.bsky.social · 31/12/2025
Thrilled to share the first major preprint from the lab. Viruses are classically viewed as targets of host sensing. Do viruses also sense and respond to the host? We propose viruses may act as “biosensors” of the host signaling state. A thread👇🏾 www.biorxiv.org/content/10.1...
biorxiv.org
Global Landscape of Human Kinase Motifs in Viral Proteomes
Viruses are classically viewed as targets of host sensing, yet whether they also sense and respond to host cues remains largely unexplored. We propose that host-driven post-translational modification ...
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Alex Matia @alexmatia.bsky.social · 10/12/2025
The subclade K of influenza virus is currently 80% of the H3N2 circulating worldwide nextstrain.org/seasonal-flu...
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CIDRAP @cidrap.bsky.social · 07/10/2025
West Nile death reported in California The death, in a county where high numbers of West Nile virus-positive mosquitoes and dead birds have been found, is the fifth West Nile-related death in the state this year.
cidrap.umn.edu
West Nile death reported in California
It's the fifth West Nile virus-related death in the state this year.
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CIDRAP @cidrap.bsky.social · 20/08/2025
Europe's record mosquito-borne disease activity could signal new normal Rising temperatures, longer summers, milder winters, and changing rainfall patterns are creating more favorable conditions for mosquito populations. www.cidrap.umn.edu/c... Photo: Judy Gallagher/Flickr cc
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Shira Weingarten-Gabbay @shiraweingarten.bsky.social · 12/06/2025
If you love #viruses, #ribosomes, and genomic #darkmatter, this thread is for you!! 💫 We're excited to share our new publication developing Massively Parallel Ribosome Profiling (MPRP), which uncovered ~4,000 hidden proteins in ~700 viral genomes. www.science.org/doi/10.1126/...
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Nature Microbiology @natmicrobiol.nature.com · 28/05/2025
🚨 Out now! Distinct non-canonical translation initiation modes arise for specific host and viral mRNAs during poxvirus-induced shutoff #MicroSky 🦠 #NorthwesternUniversity #FeinbergSchoolofMedicine www.nature.com/articles/s41...
nature.com
Distinct non-canonical translation initiation modes arise for specific host and viral mRNAs during poxvirus-induced shutoff - Nature Microbiology
During poxvirus-induced shutoff, certain cellular and viral mRNAs continue to be translated through distinct modes of non-canonical initiation, in part due to altered ribosome activity, to produce hos...
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CIDRAP @cidrap.bsky.social · 21/04/2025
Vietnam reports H5N1 avian flu case with encephalitis Tests on respiratory samples were negative, but results were positive for the cerebrospinal fluid sample. www.cidrap.umn.edu/a...
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Julie Tai-Schmiedel @julietai.bsky.social · 26/03/2025
Out now at @nature.com The entry receptor for enterovirus D68 👀 www.nature.com/articles/s41...
nature.com
MFSD6 is an entry receptor for enterovirus D68 - Nature
Nature - MFSD6 is an entry receptor for enterovirus D68
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Alex Matia @alexmatia.bsky.social · 15/03/2025
Aging might not be enough to eliminate H5N1 viruses in raw-milk cheese. #H5N1 www.cidrap.umn.edu/avian-influe...
cidrap.umn.edu
Aging might not be enough to eliminate H5N1 viruses in raw-milk cheese
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California Department of Public Health @capublichealth.bsky.social · 27/02/2025
📣Measles is an extremely contagious virus. Make sure you and your family are up to date on your measles vaccine to stay protected. 📲 Find more vaccination information at: cdph.ca.gov/Programs/CID/DCDC/Pages/Immunization/family.aspx. #Measles #Vaccinate #StayHealthy #HealthyCA4All
A white and gray background with blue circles. A family of four sits together. "Protect the youngest among us! Stay up to date on your measles vaccine."
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Emily Blythe @emilyblythe.bsky.social · 04/03/2025
We're hiring! Join the Blythe lab as a full-time junior researcher starting Summer 2025. Explore GPCR trafficking and signaling using biochemistry, cell biology, and proteomics. Mentorship, hands-on experience, and career growth await! Apply now: hr.myu.umn.edu/jobs/ext/367... (UMN job ID #367053)
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Helen Branswell 🇨🇦 @helenbranswell.bsky.social · 14/02/2025
Because there's not enough going on: Arizona has found #H5N1 #birdflu in milk and it looks like yet another spillover from wild birds. www.statnews.com/2025/02/14/a...
statnews.com
Bird flu found in Arizona milk suggests another spillover from birds to cows
Another spillover of the H5N1 bird flu virus from wild birds to dairy cattle appears to have occurred, this time in Arizona.
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American Society for Virology @amersocvirology.bsky.social · 13/02/2025
Vaccines work! As measles cases have recently been reported in Alaska, Georgia, New York, Rhode Island and Texas, it's important to remember that prior to the introduction of the measles vaccine in 1963, measles killed 400-500 people and resulted in ~48,000 hospitalizations per year.
Graph showing that prior to 1963 when the measles vaccine was introduced, there were around 300,000-700,000 measles cases per year. Within a few years of the vaccine, the number of cases fell below 20,000/year. There were a blips where cases rose, but shortly after the second vaccine dose was recommended in 1989, annual cases have generally been well below 1,000 cases. In 2000, measles elimination was declared in the US. Now we have sporadic outbreaks that typically spread among unvaccinated people. Chart is from Center for American Progress and is based on CDC data on measles cases.
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European Virus Bioinformatics Center @evbc.bsky.social · 19/01/2025
🚨 🌟 Submissions & Registrations Open for #ViBioM2025! 🌟 🚨 Join us 13–15 May 2025 in Lisbon, Portugal! 🦠💻 Present your research, connect with global experts, and shape the future of #Virology & #Bioinformatics. 📅 Details & links: evbc.uni-jena.de/events/vibio...
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Alex Matia @alexmatia.bsky.social · 09/01/2025
A coronavirus that is able to bind the human ACE2 receptor has been found in Spain! @csic.es www.biorxiv.org/content/10.1...
biorxiv.org
Identification and characterization of novel bat coronaviruses in Spain
The zoonotic transmission of bat coronaviruses poses a threat to human health. However, the diversity of bat-borne coronaviruses remains poorly characterized in many geographical areas. Here, we recov...
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Alex Matia @alexmatia.bsky.social · 02/01/2025
A great reminder that not only respiratory viral infections rise during the winter season, but other pathogens like #Norovirus also come in yearly waves.
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The New York Times @nytimes.com · 31/12/2024
There have been an unusually high number of norovirus outbreaks in the U.S. this month, according to the CDC. Here’s what to know about symptoms, treatment, and reducing your risk of infection. nyti.ms/4gyr6JO
A man in a white T-shirt is pictured clutching his stomach while lying in bed. Headline reads: "Norovirus Outbreaks Surge Nationwide, CDC Says." Photo credit: Getty Images.
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Alex Matia @alexmatia.bsky.social · 01/01/2025
From conjunctivitis to critical illness in 96 hours after infection with #H5N1 influenza (the bird strain D1.1). Three antivirals plus plasma exchange treatment were necessary 👀. www.nejm.org/doi/full/10....
nejm.org
Critical Illness in an Adolescent with Influenza A(H5N1) Virus Infection | NEJM
Influenza A(H5N1) viruses are an emerging zoonotic threat and have spread widely throughout birds in North America. Recently, influenza A(H5N1) infection led to serious illness in a teenager in Canada...
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Alex Matia @alexmatia.bsky.social · 28/12/2024
Flu season is here. Watch out and take care. ...and let's hope no reassortments with #H5N1 occur. www.cdc.gov/fluview/surv...
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Alex Matia @alexmatia.bsky.social · 19/12/2024
Gov. Newsom declares emergency in California after CDC confirms severe case of bird flu in Louisiana www.latimes.com/environment/... #HPAI #H5N1
latimes.com
Gov. Newsom declares emergency in California after CDC confirms severe case of bird flu in Louisiana
As the CDC confirmed a severe case in Louisiana of a patient hospitalized with H5N1 bird flu, Gov. Gavin Newsom declared a state of emergency in California related to the virus.
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Ruth Huttenhain @rhuttenhain.bsky.social · 06/12/2024
Hello world! After my lab has been operating in "stealth mode" for 1.5 years, I am excited to announce that we finally have a website: www.huttenhainlab.com By the way I'm also hiring and looking for a postdoc with proteomics experience: postdocs.stanford.edu/prospective/... #TeamMassSpec
huttenhainlab.com
Huttenhain Lab | Home
The Huttenhain Lab at Stanford University studies cellular signaling networks to uncover how cells decode extracellular cues into dynamic physiologic responses.
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Infectious Disease Tracker @hmpxvt.bsky.social · 24/11/2024
⚠️ BREAKING: California state health officials confirmed that H5N1 bird flu virus has been detected in sold raw milk from the Fresno-based Raw Farm dairy. Santa Clara County public health officials collected the sample.
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bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 14/01/2024
Spatio-temporal analysis of Vaccinia virus infection and host response dynamics using single-cell transcriptomics and proteomics www.biorxiv.org/content/10.1101/202…
biorxiv.org
Spatio-temporal analysis of Vaccinia virus infection and host response dynamics using single-cell transcriptomics and proteomics https://www.biorxiv.org/content/10.1101/2024.01.13.575413v1
Poxviruses are a large group of DNA viruses with exclusively cytoplasmic life cycles and complex gen
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Marco Hein @marco.heinlab.org · 17/01/2024
Check out our new preprint, describing the transcriptional and proteomic events during Vaccinia virus infection in human cells. Spearheaded by the incomparable @alexmatia.bsky.social, who spent a few super productive months with Carolina Arias and me at the Biohub. #LoveVirology #PoxRocks
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Alex Matia @alexmatia.bsky.social · 17/01/2024
📣NEW PREPRINT ALERT! Thrilled to share our latest research delving deep into Vaccinia virus infection dynamics using scRNAseq and fractionation proteomics: -Antiviral response dynamics -Host and virus proteomic maps -Proteome relocation #lovevirology #poxrocks 🧵👇
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