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Alexandre Jorge Pinto

@alexjpinto.bsky.social
134 followers 126 following 2 posts

Research Fellow @ i3S | Tuberculosis Research

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Reposted by Alexandre Jorge Pinto
Tiago Beites @tiagobeites.bsky.social · 20/04/2026
How does Mycobacterium tuberculosis safely eat an antimicrobial (host-derived long-chain fatty acids)? Here we show that it’s not through a dedicated mechanism but rather by fine tuning its metabolism. www.nature.com/articles/s42...
nature.com
Mycobacterium tuberculosis long-chain fatty acid resistome reveals universal stress protein TB15.3 as essential for infection - Communications Biology
A genetic screen identifies long-chain fatty acid resistance mechanisms in Mycobacterium tuberculosis, and highlights a universal stress protein required for balanced long-chain fatty acid degradation...
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Reposted by Alexandre Jorge Pinto
Tiago Beites @tiagobeites.bsky.social · 20/04/2026
Team work of my PhD students @alexjpinto.bsky.social and @marcopsilva.bsky.social and postdoc Rodrigo Monteiro. Collaborations with Joana A. Santos and Brian VanderVen. A story that started when I had the privilege to work with @saehrt.bsky.social and Dirk Schnappinger.
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Reposted by Alexandre Jorge Pinto
Tiago Beites @tiagobeites.bsky.social · 07/12/2025
Mycobacterium tuberculosis is an outlier in many ways. One of them is keeping a high degree of functional redundancy despite its obligate pathogen lifestyle. In this review, we reflect on the biological meaning of M. tuberculosis functional redundancies. journals.plos.org/plospathogen...
journals.plos.org
Essential redundancies fuel Mycobacterium tuberculosis adaptation to the host
Redundancy in biology is, at a glance, counterintuitive because if the function of two gene products completely overlaps then, throughout the course of evolution, one of the genes will likely accumula...
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Reposted by Alexandre Jorge Pinto
Tiago Beites @tiagobeites.bsky.social · 07/12/2025
Excellent teamwork with my talented PhD students @marcopsilva.bsky.social and @alexjpinto.bsky.social Also happy because this is the first outcome 100% @i3suporto.bsky.social made. Hopefully, the first of many more to come.
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Alexandre Jorge Pinto @alexjpinto.bsky.social · 15/04/2025
I'm excited to share my first, first-author paper!
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Reposted by Alexandre Jorge Pinto
bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 15/04/2025
The Mycobacterium tuberculosis long-chain fatty acid resistome reveals the universal stress protein TB15.3 as essential for infection www.biorxiv.org/content/10.1101/202…
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Reposted by Alexandre Jorge Pinto
Tiago Beites @tiagobeites.bsky.social · 12/02/2025
What a great conference #EMBOtuberculosis has been! Amazing science, amazing food and a very friendly community! And it was a pleasure to share the work we’re developing at i3S U. Porto.
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Alexandre Jorge Pinto @alexjpinto.bsky.social · 26/11/2024
Excited to share the work I have been a part of and also my first paper, regarding how different strains of Mycobacterium tuberculosis induce IL-1B production and inflamassome activation academic.oup.com/jid/advance-...
academic.oup.com
Genetically diverse Mycobacterium tuberculosis isolates manipulate inflammasome activation and IL-1β secretion independently of macrophage metabolic rewiring
The glycolytic pathway is required for maximum IL-1β production by macrophages infected with live distinct M. tuberculosis isolates, but mitochondria metab
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Reposted by Alexandre Jorge Pinto
Tiago Beites @tiagobeites.bsky.social · 17/11/2024
Introducing my wonderful team at i3S - University of Porto. PhD student @marcopsilva.bsky.social and research fellow @alexjpinto.bsky.social
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