iiinova — where your digital self keeps evolving

Reposted by Alex Chu

Polly Fordyce @pollyfordyce.bsky.social · 13/12/2024

Many industrially-important reactions (e.g. lipase-catalyzed biofuel production) involve substrates poorly soluble in water. How can we screen enzymes for these reactions? Samuel Thompson invented a new 'triple emulsion' platform for biphasic screening (1/n): onlinelibrary.wiley.com/doi/full/10....

onlinelibrary.wiley.com

FACS‐Sortable Triple Emulsion Picoreactors for Screening Reactions in Biphasic Environments

Biphasic reactions can enhance reactions where the catalyst and substrate have different solvent preferences. This study optimizes triple emulsion picoreactors that encapsulate a biphasic solvent env...

13310

Alex Chu @alexechu.bsky.social · 09/12/2024

At neurips this week - hmu if you’re around, want to catch up, try out some food, explore, etc!

050

Reposted by Alex Chu

Frank Noe @franknoe.bsky.social · 06/12/2024

Super excited to preprint our work on developing a Biomolecular Emulator (BioEmu): Scalable emulation of protein equilibrium ensembles with generative deep learning from @msftresearch.bsky.social ch AI for Science. www.biorxiv.org/content/10.1...

21441147

Reposted by Alex Chu

Zeming Lin @ebetica.bsky.social · 04/12/2024

Evolution is non-linear, the next step in the evolutionary lineage of the ESM series of models is a sequence only protein language model that sets a new state of the art in representation learning. Check it out! The 300M and 600M models are open weights, 300M available for commercial usage.

1144

Reposted by Alex Chu

AI Proteins @aiproteins.com · 03/12/2024

AI Proteins is excited to partner with @bms-news.bsky.social to develop novel miniprotein-based therapeutics. This collaboration will leverage our cutting-edge AI-driven platform to design and optimize miniproteins with the potential to transform patient outcomes www.businesswire.com/news/home/20...

businesswire.com

AI Proteins Announces Research Collaboration and Option Agreement with Bristol Myers Squibb for Miniprotein-Based Therapeutics Valued up to $400M

AI Proteins, Inc., a biotechnology company that utilizes computational de novo protein design to create therapeutic miniproteins, today announced that

132

Reposted by Alex Chu

Peyman Milanfar @docmilanfar.bsky.social · 03/12/2024

“On a log-log plot, my grandmother fits on a straight line.” -Physicist Fritz Houtermans There's a lot of truth to this. log-log plots are often abused and can be very misleading 1/5

14513

Reposted by Alex Chu

Arne Elofsson @handle.invalid · 03/12/2024

AF3 BEST METHOD followed by cluspro but also some conversion errors

22210

Reposted by Alex Chu

Joanna Slusky @joannas.bsky.social · 17/11/2024

go.bsky.app/BoXpqQp Computational protein design starter pack. Let me know if I missed you!

185814

Reposted by Alex Chu

Gautam Kamath @gautamkamath.com · 27/11/2024

Asking the following earnestly: what is the strongest case for GANs standing the "test of time"? Are they important 10 years later in modern ML research? How have they influenced the way we think about generative models today?

18645

Reposted by Alex Chu

Sander Dieleman @sedielem.bsky.social · 27/11/2024

Amazing blog post on flow matching, stunning visuals! It also makes the connection with normalising flows crystal clear. Incredible effort!

29016

Reposted by Alex Chu

Simon Mathis @simonmathis.bsky.social · 25/11/2024

A weekend project from a while back -- this little package (with no dependencies) allows you to interact with pymol remotely. I use it a lot for my protein design workflows together with @biotite.bsky.social. Just `pip install pymol-remote`

44713

Reposted by Alex Chu

Kevin K. Yang 楊凱筌 @kevinkaichuang.bsky.social · 13/11/2024

Experimental kcat and KM measurements for hundreds of naturally variants of adenylate kinase. - thermophilic enzymes are not slower than mesophilic! - general kcat/KM predictors are bad and easily beaten by models trained on this specific dataset! www.biorxiv.org/content/10.1...

2165