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Alex Cammack

@alexcammack.bsky.social

176 followers 104 following 0 posts

Postdoctoral fellow at UCL and the UK DRI

Posts Replies Media

Reposted by Alex Cammack

Abraham Acevedo @acevedolab.bsky.social · 30/04/2025

Our new review on the challenges of modelling TDP-43 pathology in mice is just out: rdcu.be/ejZ5a As usual, together with Lizzy Fisher. Thanks to Jose Brito and @lucastaoro.bsky.social from the lab for putting the data together for the comprehensive tables.

rdcu.be

Challenges of modelling TDP-43 pathology in mice

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Reposted by Alex Cammack

Adrian Isaacs @adrianisaacs.bsky.social · 11/02/2025

A first description of the C9 repeat iNDI lines is now on bioRxiv, a collaboration from genome engineering through cell biology to facilitate ALS/FTD research @michael-e-ward.bsky.social @jacksonlab.bsky.social @cziscience.bsky.social www.biorxiv.org/content/10.1...

biorxiv.org

Generation of C9orf72 repeat knock-in iPSC lines for modelling ALS and FTD

Induced pluripotent stem cell (iPSC) models are powerful tools for neurodegenerative disease modelling, as they allow mechanistic studies in a human genetic environment and they can be differentiated ...

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Reposted by Alex Cammack

Adrian Isaacs @adrianisaacs.bsky.social · 08/01/2025

First post here! Our latest paper showing CRISPR-CasRx can target both sense and antisense C9orf72 repeats is just out! rdcu.be/d5ADQ co-led by @alexcammack.bsky.social @ukdri.bsky.social @uclqsion.bsky.social

rdcu.be

Dual-targeting CRISPR-CasRx reduces C9orf72 ALS/FTD sense and antisense repeat RNAs in vitro and in vivo

Nature Communications - CRISPR-CasRx effectively reduces ALS- and FTD-causing C9orf72 sense and antisense repeat derived RNAs and proteins in cell lines, patient iPSC-neurons and two independent...

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