Sign in

alexandrebelot.bsky.social

@alexandrebelot.bsky.social
120 followers 97 following 6 posts

MD, PhD, professor of pediatric rheumatology & immunology

PostsRepliesMedia
Reposted by @alexandrebelot.bsky.social
Casanova Lab @casanovalab.bsky.social · 07/04/2026
Does anyone have serum/plasma from a cohort of (ambulatory) patients with herpes zoster (shingles) ? A small cohort would be fine. We will test if they have auto-Abs against type I IFNs, as the risk of zoster increases over 50 yo. Please RT or contact me !
146
alexandrebelot.bsky.social @alexandrebelot.bsky.social · 02/04/2026
When pediatric lupus behaves like a Mendelian disease: #Monogeniclupus, @hcl-recherche.bsky.social @ciri-lyon.bsky.social, @frl-lab.bsky.social Important implications for personalized care👇 WES enables molecular diag in 10% of pediatric SLE cases eBioMedicine www.thelancet.com/journals/ebi...
thelancet.com
Exome sequencing enables molecular diagnosis in 10% of early-onset or familial systemic lupus erythematosus cases
This study expands our understanding of causes of lupus, highlighting its genetic heterogeneity. It also supports the systematic use of genetic testing in cases of juvenile lupus, especially those wit...
185
Reposted by @alexandrebelot.bsky.social
Casanova Lab @casanovalab.bsky.social · 12/01/2026
Another superb study of human TLR7 GOF: Novel TLR7 gain-of-function variant and review of the associated disease spectrum url: rupress.org/jhi/article/...
rupress.org
Novel TLR7 gain-of-function variant and review of the associated disease spectrum | Journal of Human Immunity | Rockefeller University Press
This study identifies a novel TLR7 variant causing monogenic lupus, recurrent infections, and neuroinflammation. The phenotype resembles type I interferono
072
Reposted by @alexandrebelot.bsky.social
Journal of Human Immunity @jhumimmunity.org · 12/01/2026
New from Tusseau, Desvignes, Belot et al. @ciri-lyon.bsky.social: Novel TLR7 GOF variant (P435S) causing early onset #lupus with #neuroinflammation. Functional validation & review of all known #TLR7 GOF cases. A new dive into TLR7 mediated #autoimmunity. rupress.org/jhi/article/... #InnateImmunity
033
Reposted by @alexandrebelot.bsky.social
Casanova Lab @casanovalab.bsky.social · 08/01/2026
A fascinating report, unifying MIS-C and MIS-A: Shared TCR Vβ21.3+ T cell immunological signature between MIS-A and MIS-C url: rupress.org/jhi/article/...
rupress.org
Shared TCR Vβ21.3+ T cell immunological signature between MIS-A and MIS-C | Journal of Human Immunity | Rockefeller University Press
The immune dysregulation in SARS-CoV-2–related multisystem inflammatory syndrome in adults (MIS-A) is not fully characterized. In this work, Khoryati et al
073
Reposted by @alexandrebelot.bsky.social
Journal of Human Immunity @jhumimmunity.org · 08/01/2026
Khoryati et al. identify a T cell receptor Vβ21.3 signature in #SARSCoV2–related multisystem inflammatory syndrome in adults (MIS-A) similar to that previously reported in children (MIS-C), suggesting a shared immune-related mechanism between the two conditions. rupress.org/jhi/article/...
054
Reposted by @alexandrebelot.bsky.social
Rockefeller University Press @rupress.org · 08/01/2026
In @jhumimmunity.org: Khoryati et al. identify a T cell receptor Vβ21.3 signature in #SARSCoV2–related multisystem inflammatory syndrome in adults (MIS-A) similar to that previously reported in children (MIS-C), suggesting a shared immune-related mechanism between the two rupress.org/jhi/article/...
033
Reposted by @alexandrebelot.bsky.social
Laura Lewandowski @lupusdnadoc.bsky.social · 14/06/2025
Congratulations to Dr Eve Smith for EULAR abstract award-Clinical Science for our collaboration in childhood-onset #lupus! Thankful to FOREUM-RRF for funding this exciting international collaboration to advance clinical research for cSLE! More great things ahead! #EULAR25 #lupus 👏🏽👏🏽👏🏽🩺🔬💻
2132
Reposted by @alexandrebelot.bsky.social
Journal of Human Immunity @jhumimmunity.org · 23/04/2025
Human #InbornErrorsOfImmunity: 2024 update on the classification from the @iuis-online.bsky.social Expert Committee: rupress.org/jhi/article/... See also the accompanying diagnostic guide by Bousfiha et al.: rupress.org/jhi/article/...
073
Reposted by @alexandrebelot.bsky.social
Journal of Human Immunity @jhumimmunity.org · 15/04/2025
The first JHI articles are online! Poli et al present the 2024 update of the @iuis-online.bsky.social classification of #InbornErrorsOfImmunity (rupress.org/jhi/article/...) & Bousfiha et al provide an accompanying phenotypic classification to assist clinical diagnoses (rupress.org/jhi/article/...)
0155
alexandrebelot.bsky.social @alexandrebelot.bsky.social · 28/02/2025
Nice overview of SOCS1 HA, a recently identified JAK-STATopathy with many phenotypes
030
Reposted by @alexandrebelot.bsky.social
ACR Journals @acr-journals.bsky.social · 20/02/2025
Review explores the impact of rare genetic variants on the understanding and treatment of autoimmune and autoinflammatory diseases, with a focus on systemic lupus erythematosus and Behçet syndrome In ACR Open Rheumatology doi.org/10.1002/acr2... #Medsky
How (Ultra-)Rare Gene Variants Improve Our Understanding of More Common Autoimmune and Inflammatory Diseases. Graphical abstract created with BioRender
0125
Reposted by @alexandrebelot.bsky.social
Vanessa Sancho Shimizu @sanchoshimizu.bsky.social · 18/02/2025
*******JOB ALERT********* Join our team as a Postdoc or Research Assistant investigating the genetic basis of life-threatening infections in children @imperialcollege . Apply now 🔗 rb.gy/1c6b3n #ScienceJobs #Postdoc #Immunology #IEI #Humangenetics @imperialinfect.bsky.social
rb.gy
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
054
alexandrebelot.bsky.social @alexandrebelot.bsky.social · 08/02/2025
I agree, this is a drama for the whole scientific community.
030
Reposted by @alexandrebelot.bsky.social
Marie-Louise Frémond @mlfremond.bsky.social · 31/01/2025
📣 À vos agendas ! N’hésitez pas à vous inscrire www.eventbrite.com/e/mip-2025-t...
eventbrite.com
MIP 2025
12ème Journée de Médecine Interne Pédiatrique et 7ème journée du CRMR RAISE
063
alexandrebelot.bsky.social @alexandrebelot.bsky.social · 21/01/2025
Bravo Petter and coll, well done!
050
alexandrebelot.bsky.social @alexandrebelot.bsky.social · 02/01/2025
Fascinating work by @bogunoviclab.bsky.social and colleagues, new perpectives for penetrance / expressivity analyses of monogenic diseases. 👏🎊
030
Reposted by @alexandrebelot.bsky.social
Hospices Civils de Lyon @hospicescivilslyon.bsky.social · 31/12/2024
🩵 MERCI aux équipes de nuit qui assurent la continuité des soins, même le 31 déc. : urgences, bloc, maternité, usld, imagerie médicale, laboratoire, maintenance, transport, restauration, nettoyage, accueil, sécurité, équipes mobiles ou de garde... #TeamHCL #HôpitalPublic 📸 O. Ruffini BellecourEcole
Intérieur, un couloir peu éclairé. 2 personnels hospitaliers de dos en tenue bleue avec masque et charlotte médicale, poussant un brancard. Au fond du couloir, entre 2 portes, une vive lumière à travers un bureau vitré.
093
Reposted by @alexandrebelot.bsky.social
Rémi Salomon @remisalomon.bsky.social · 29/12/2024
Il y a deux ans nous avions sonné l'alarme auprès du PR, des Assises de la pédiatrie étaient lancées. De nombreux professionnels se sont concertés et on fait des propositions en mai 2024. Qu'en a-t-on retenu ? Après les paroles et les promesses, l'action s'impose. www.lemonde.fr/societe/arti...
lemonde.fr
Emmanuel Macron annonce la création d’un haut-commissariat à l’enfance en janvier
En France, un enfant sur cinq vit sous le seuil de pauvreté, et 160 000 sont victimes de violences sexuelles chaque année, selon la Dynamique pour les droits des enfants, qui porte la voix d’associati...
173
Reposted by @alexandrebelot.bsky.social
Nature Reviews Rheumatology @natrevrheum.nature.com · 20/12/2024
#JanuaryIssue | Emerging concepts and treatments in autoinflammatory interferonopathies and monogenic systemic lupus erythematosus Goldbach-Mansky and colleagues propose a pathogenesis-based classification of #autoinflammatory interferonopathies in this #Review bit.ly/4gLCpOx
bit.ly
Emerging concepts and treatments in autoinflammatory interferonopathies and monogenic systemic lupus erythematosus - Nature Reviews Rheumatology
This Review provides a comprehensive update on dysregulated type I interferon production and signalling in autoinflammatory interferonopathies, monogenic systemic lupus erythematosus and conditio...
0188
alexandrebelot.bsky.social @alexandrebelot.bsky.social · 07/12/2024
Fantastic Rheumatopedies Meeting 2024 with many talented researchers, including our guest speakers Filomeen Haerynck and Dan Kastner. Thank you for coming and sharing your enthusiasm for genomics and immunology.
052