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Alessandro Donada

@alessandrodonada.bsky.social
296 followers 474 following 146 posts

"Definitely still a young hematology researcher (don’t ask how young) @Institut Curie | Big on participative research & quant bio 🧪 | Wannabe Intern at the Ministry of Silly Walks

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Alessandro Donada @alessandrodonada.bsky.social · 01/08/2025
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ISEH - International Society for Experimental Hematology @isehsociety.bsky.social · 30/07/2025
The #ISEH2025 🏯 program is here and features world-renowned scientists showcasing the latest in experimental hematology. Don't miss these sessions, including the ISEH/JSH symposium on stress hematopoiesis with Drs. Toshio Suda and Hitoshi Takizawa ➡️ www.iseh.org/2025Scientif...
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Alessandro Donada @alessandrodonada.bsky.social · 31/07/2025
So interesting!
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Alessandro Donada @alessandrodonada.bsky.social · 25/07/2025
A gentleman and a scholar indeed! What a pleasant chat with @abattacks.bsky.social, make sure to check out our interview! Also, a submitted post from @lvchosen1.bsky.social and at least 25 preprints to review! #hemesky
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Alessandro Donada @alessandrodonada.bsky.social · 21/07/2025
Let's do this!
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Alessandro Donada @alessandrodonada.bsky.social · 02/07/2025
Best way to keep up with the newest research! #HemeSky
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Alessandro Donada @alessandrodonada.bsky.social · 25/06/2025
This project was led with @perielab.bsky.social, with the help of amazing collaborators — shoutout to Gurvan, CSCO, Tiziana, and the clinicians. Want to know more? Send me a message, or comment here!
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Alessandro Donada @alessandrodonada.bsky.social · 25/06/2025
🔮 Where are we headed next? Can we restore epigenetic structure in AML more robustly? How stable is clonal memory over time, stress, or environment? Let’s find out.
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Alessandro Donada @alessandrodonada.bsky.social · 25/06/2025
🧨 In AML, the memory breaks down. → Cell families get chaotic → Division becomes erratic → Concordance is lost But: tweaking the epigenetic landscape brings some order back. 🙏 Huge thanks to patients & clinicians who made this part possible.
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Alessandro Donada @alessandrodonada.bsky.social · 25/06/2025
🧬 What about gene expression? No one-size-fits-all “family module,” but expression fingerprints are shared within families. And I want to thank the @CSCO platform at Curie for the data & Tiziana Tocci for the beautiful network analysis!
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Alessandro Donada @alessandrodonada.bsky.social · 25/06/2025
📐 Could this all be random? We built a mathematical model (thanks to Gurvan Hermange) to test it. Still: ✅ Homogeneity in fate ✅ Concordance in division ...emerged as essential features.
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Alessandro Donada @alessandrodonada.bsky.social · 25/06/2025
🧬 It’s not just division. Cell families also: → Look alike → Choose similar fates The big differences are between families, not within. 🧭 Lineage tracing was key.
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Alessandro Donada @alessandrodonada.bsky.social · 25/06/2025
👪 Cells from the same ancestor — “families” — often: ✔️ Divide the same number of times ✔️ At the same time ⏱️ And this holds across donors, media & time.
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Alessandro Donada @alessandrodonada.bsky.social · 25/06/2025
🔬 We took a multi-omic, single-cell approach: Live-cell imaging Single-cell RNA-seq (thanks CSCO platform!) Custom assay for lineage + division + differentiation --> introducing MultiGen (DOI: 10.3791/64918)
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Alessandro Donada @alessandrodonada.bsky.social · 25/06/2025
Why HSPCs? 🩸 These stem cells build the entire blood system. If they remember division patterns, it affects how we understand both healthy haematopoiesis and disease.
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Alessandro Donada @alessandrodonada.bsky.social · 25/06/2025
Cells divide, differentiate, and move on… right? 🧠 But we asked: do blood stem cells remember their past divisions? Spoiler: they do — and it’s surprisingly organized.
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Alessandro Donada @alessandrodonada.bsky.social · 25/06/2025
🧬 What if your blood cells remembered how their ancestors divided? Our new preprint (www.biorxiv.org/content/10.1...) explores clonal memory in human blood stem cells — and how it breaks down in leukaemia. 📄 "Clonal memory of cell division..."
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Alessandro Donada @alessandrodonada.bsky.social · 25/06/2025
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Alessandro Donada @alessandrodonada.bsky.social · 24/06/2025
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HemaSphere Journal @hemasphere-journal.bsky.social · 24/06/2025
This Article analyzes human hematopoiesis in humanized bone marrow in immune-deficient mice, showing dynamic structures supporting human hematopoietic development. Findings emphasize significance of the models for investigating human hematopoietic development & leukemogenesis👉https://bit.ly/42Czbaw
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Ronan Chaligné @ronanchaligne.bsky.social · 23/06/2025
🚨🚨 We're hiring! 🚨🚨 The Single-cell Analytics Innovation Lab (SAIL) at @mskcancercenter.bsky.social is looking for a Junior Technician to join our wet lab team! You'll work with spatial genomics and single-cell technologies, helping us push the boundaries of cutting-edge analysis in cancer research.
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Alessandro Donada @alessandrodonada.bsky.social · 10/06/2025
What are you waiting for? Best society you can be involved in!
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Alessandro Donada @alessandrodonada.bsky.social · 10/06/2025
Such a beautiful example of how little we know and understand about biology! In my Top3 together with tardigrades and the naked mole rat!
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Alessandro Donada @alessandrodonada.bsky.social · 06/06/2025
Make him pay ladies. And a lot of respect for a postdoc taking this type of stance, we can only hope to be like that.
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ISEH - International Society for Experimental Hematology @isehsociety.bsky.social · 03/06/2025
Invited speaker @trowbridgelab.bsky.social‬ will share her work this September at #ISEH2025 🏯 Learn more about the incredible science to expect this year and register today! youtu.be/RnyyurVaZrc
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Vanessa Scanlon, PhD @vanessascanlon.bsky.social · 04/06/2025
Calls for volunteers to serve on a variety of committees for the @isehsociety.bsky.social are open now! Check out these opportunities if you're interested in developing leadership skills and your professional network. It takes a village! www.iseh.org/page/ISEHCom...
iseh.org
ISEH Committees - International Society for Experimental Hematology
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Alessandro Donada @alessandrodonada.bsky.social · 02/06/2025
Find 20 minutes of your time and listen to this interview, plenty of valuable insights!
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Alessandro Donada @alessandrodonada.bsky.social · 02/06/2025
That's a brilliant interview, with some genuine takes on this entire business of understanding blood cells :)
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Keisuke Ito @keisukeito-lab.bsky.social · 23/05/2025
Excited to see the first commentary in Experimental Hematology (@isehsociety.bsky.social)! Kudos to Aishwarya, Linde ‪@lindemileslab.bsky.social, and Grant @challenlab.bsky.social for highlighting recent papers in Exp Hem on cell-extrinsic factors in Tet2-mutant clonal hematopoiesis!! bit.ly/4k3pEAI
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Cell-extrinsic factors contribute toward myeloid-biased expansion in Tet2-mutant clonal hematopoiesis
Hematopoietic stem cells (HSCs) acquire somatic mutations throughout life, with the frequency of mutational incidence increasing with age [1]. Occasionally, certain mutations confer a fitness advantag...
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José Luis Sardina @jlsardinalab.bsky.social · 22/05/2025
🔬 Passionate about experimental hematology? Apply now for the final @carrerasleaders.bsky.social Call and join our team to work at the intersection of epigenetics, chromatin biology, and blood cancer. #Hematology #Epigenetics #postdoc Learn more (shorturl.at/5x5sw) & Apply 👇
shorturl.at
Epigenetic control of haematopoiesis
DNA methylation-related genes are among the most frequently mutated in blood malignancies. Traditionally, studies aimed at understanding the effect of aberra...
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Alessandro Donada @alessandrodonada.bsky.social · 22/05/2025
That was a great chat, Christiana really nailed it! Have a look, her work is an absolute must, and a really original approach to long-standing questions on HSCs division
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Blood Journals Portfolio @bloodjournals.hematology.org · 20/05/2025
Normal human HSCs do not require FLT3 to engraft and sustain hematopoiesis. buff.ly/cfOqhWD #hemesky #myeloidneoplasia
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Alessandro Donada @alessandrodonada.bsky.social · 20/05/2025
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Nick van Gastel @nickvangastel.bsky.social · 19/05/2025
New paper from our lab! In this study, we show that AML cells critically depend on LDHA to maintain their NAD+/NADH balance. Congrats to first author Ayşegül Erdem and all co-authors! cancerandmetabolism.biomedcentral.com/articles/10....
cancerandmetabolism.biomedcentral.com
Lactate dehydrogenase A-coupled NAD+ regeneration is critical for acute myeloid leukemia cell survival - Cancer & Metabolism
Background Enhanced glycolysis plays a pivotal role in fueling the aberrant proliferation, survival and therapy resistance of acute myeloid leukemia (AML) cells. Here, we aimed to elucidate the extent...
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ISEH - International Society for Experimental Hematology @isehsociety.bsky.social · 19/05/2025
Tomorrow - Register for the NIC Gene Therapy webinar with Dr. Mitchell Weiss and Prof. Luigi Naldini. Join live to hear about gene therapy for hemoglobinopathies and emerging gene editing technologies ➡️ www.iseh.org/ISEHWebinars
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Paris Postdocs Seminars @parispostdocs.bsky.social · 19/05/2025
This month’s #ParisPostdocsSeminar features @laurasalavessa.bsky.social from @inem-necker.bsky.social, presenting her latest results on the transfer and uptake of melanin in keratinocytes for skin homeostasis! 📅 Tuesday, 27 May 2025 🕚 11:00–12:00 CET 📍 Amphitheatre Agnès Ullmann, @pasteur.fr
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Alessandro Donada @alessandrodonada.bsky.social · 19/05/2025
"Peer review can be thought of as a zero sum game:[...] I submit harsh reviews because those are what I get on my own papers." Brilliant reading from @biologists.bsky.social's Journal of Cell Science journals.biologists.com/jcs/article/...
journals.biologists.com
Let's review I
Good morning, bonjour, buongiorno, guten morgen, dzien dobry, maj po! (Sorry if I left out your language, but I did get you if you are Klingon. In any case, hi there!). It is a bea-u-ti-ful spring day...
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ISEH - International Society for Experimental Hematology @isehsociety.bsky.social · 18/05/2025
⏰ Time is running short! ONE day left to submit your abstract and travel grant application to #ISEH2025 🏯. 👉 www.iseh.org/2025Abstracts
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Alessandro Donada @alessandrodonada.bsky.social · 16/05/2025
If your research is heavy on mouse models and Clonal Haematopoiesis, you must read the report from @haemev.bsky.social and colleagues on sex-differences on the classic BL6 TET2 KO model! Congratulations to all the authors highlighted in this post!
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Alessandro Donada @alessandrodonada.bsky.social · 15/05/2025
Someone said 1,000,000 single cells in a single run?
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Alessandro Donada @alessandrodonada.bsky.social · 15/05/2025
Congrats Josh!
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ISEH - International Society for Experimental Hematology @isehsociety.bsky.social · 13/05/2025
The May #ExpHem issue is here! Explore the articles, including D816V KIT mutation induces mitochondrial morphologic and functional changes through BNIP3 downregulation in human myeloid cell lines ROSA and TF-1. www.exphem.org/current
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Alessandro Donada @alessandrodonada.bsky.social · 15/05/2025
The more the merrier! I have been involved for a few years now, and the committees are a great place to give back to the Society and the community. Happy to chat more about my experience!
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Alessandro Donada @alessandrodonada.bsky.social · 18/04/2025
Absolute pleasure to chat with Jane, go and have a read! @drjanexu.bsky.social
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Alessandro Donada @alessandrodonada.bsky.social · 14/04/2025
"...your work is an act of resistance. Every experiment, every line of code, every collaboration defies those who would silence science. Keep going." www.nature.com/articles/d41...
nature.com
Dear US researchers: break the outrage addiction. I survived the besieging of science. So can you
As I watch US researchers respond to threats against science, I’m reminded of when scientists in Brazil navigated a similar storm.
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Maxim Greenberg @maxvcg.bsky.social · 11/04/2025
The Americans are doing to Kseniia what the Russians did to Brittney Griner for having 0.7 grams of cannabis oil. Except no one is coming to negotiate her freedom and Harvard is sitting on their hands. I am so ashamed. Please share this story. www.nytimes.com/2025/04/11/s...
nytimes.com
She Worked in a Harvard Lab to Reverse Aging, Until ICE Jailed Her (Gift Article)
President Trump’s immigration crackdown ensnared Kseniia Petrova, a scientist who fled Russia after protesting its invasion of Ukraine. She fears arrest if she is deported there.
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Daniel Lipka @dblipka.bsky.social · 08/04/2025
Hey #HemeSky and #EpiSci folks! We are hiring! For our Translational Cancer Epigenomics team @dkfz.bsky.social and @nct-heidelberg.bsky.social we are looking for a talented postdoc interested in research on heme malignancies and #epigenetics. Interested? 👉See jobs.dkfz.de/en/jobs/1676... or DM me!
jobs.dkfz.de
Postdoctoral Researcher
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Alessandro Donada @alessandrodonada.bsky.social · 10/04/2025
Such an excellent leadership, congratulations to all!
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ISEH - International Society for Experimental Hematology @isehsociety.bsky.social · 10/04/2025
The results are in 🗳️ Congratulations to our incoming 2025-2026 Board of Directors who will start their terms at the conclusion of #ISEH2025🏯 in September! 👏
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