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Alessandro Borsellini

@aleborsellini.bsky.social

26 followers 25 following 4 posts

Cryo-EM ❄️ and DNA biology 🧬 enthusiast.

Posts Replies Media

Reposted by Alessandro Borsellini

Elodie Carmen Leroy @ecleroy.bsky.social · 19/03/2026

Finally, we used a mild photocrosslinking strategy (pXL-EM) to improve reconstruction quality, inspired by its successful use in recent work from @alessandrovannini.bsky.social at Human Technopole, led by @aleborsellini.bsky.social. Have a look at his preprint doi.org/10.64898/202... (6/7🧵)

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Alessandro Borsellini @aleborsellini.bsky.social · 04/02/2026

I also want to point out that four other groups have achieved strikingly similar results and conclusions (science is beautiful!). Have a look at their preprint www.biorxiv.org/content/10.6... to have an even more complete picture of what is going on with condensin II activation!

biorxiv.org

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Alessandro Borsellini @aleborsellini.bsky.social · 04/02/2026

In this study we solved three cryo-EM structures and combined those snapshots with optical tweezers experiments @lumicks.bsky.social. We explain how the M18BP1 protein induces conformational changes in condensin II, making it competent for DNA binding and compaction.

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Alessandro Borsellini @aleborsellini.bsky.social · 04/02/2026

Very happy to share a new preprint from the Vannini Lab @alessandrovannini.bsky.social at @humantechnopole.bsky.social. www.biorxiv.org/content/10.6... If you are curious to understand what are the conformational changes that make condensin II able to compact the DNA during mitosis, have a read!

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Alessandro Borsellini @aleborsellini.bsky.social · 03/07/2025

Extremely happy to see this out!

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