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Alex Shackman

@ajshackman.bsky.social
2.3K followers 711 following 2K posts

Laboratory for Affective & Translational Neuroscience, University of Maryland | shackmanlab.org | affective neuroscience | "pessimism of the intellect, optimism of the will.”

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Alex Shackman @ajshackman.bsky.social · 2m
www.biorxiv.org/content/10.6...
biorxiv.org
Large-Vessel Venous Signal Confounds Apparent Amygdala Activation in BOLD fMRI
Amygdala responses are widely reported in BOLD fMRI studies of human emotions and mood disorders. Although modern acquisition methods have improved image quality, the hemodynamic nature of the BOLD si...
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Dr. Stephanie @punkrockscience.bsky.social · 01/10/2026
Today in “why men”, I I bought another bike from the local bike shop where I buy all my bikes. I wanted a “cheap” bike to put on the trainer for the winter, so I don’t have to put my fancy carbon fiber on it. I have an account there. They can see what I’ve bought.
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Alex Shackman @ajshackman.bsky.social · 29/09/2026
...and the Jeffreys–Lindley paradox (just signif frequentist p's + big'ish n's can have stronger bayesian evidence for the null) and the interpretive tricksiness of ordinal interactions (sensitivity to arbitrary scale/measure choices; e.g. time vs speed; can create, nullify, or reverse sign)...wild!
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Alex Shackman @ajshackman.bsky.social · 29/09/2026
things i've learned working w/ claude over the past 6 months - better ways to implement robust regression, better techniques for comparing dependent correlations, better ways to systematically test the robustness/fragility of brain-beh/-symptom associations, stronger exp critique (biases/confou)
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Alex Shackman @ajshackman.bsky.social · 29/09/2026
philpapers.org/rec/LYTJPB - The Jeffreys–Lindley paradox: an exchange Alexander Ly, Eric-Jan Wagenmakers, Joshua L. Cherry & Jeremy Gray
philpapers.org
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Alex Shackman @ajshackman.bsky.social · 29/09/2026
h/t claude - link.springer.com/article/10.1...
link.springer.com
History and nature of the Jeffreys–Lindley paradox - Archive for History of Exact Sciences
The Jeffreys–Lindley paradox exposes a rift between Bayesian and frequentist hypothesis testing that strikes at the heart of statistical inference. Contrary to what most current literature suggests, t...
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Alex Shackman @ajshackman.bsky.social · 29/09/2026
h/t Claude - pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov
On the interpretation of removable interactions: A survey of the field 33 years after Loftus
In a classic 1978 Memory & Cognition article, Geoff Loftus explained why noncrossover interactions are removable. These removable interactions are tied to the scale of measurement for the dependent va...
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Alex Shackman @ajshackman.bsky.social · 29/09/2026
academic.oup.com/schizophreni... Advancing Generative Artificial Intelligence for Clinical Assessment: Commentary on Chen, Horga, and Escola 2026 George Chatzisofroniou and Alex S Cohen
academic.oup.com
Validate User
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John Scalzi @scalzi.com · 26/09/2026
Whatever you do, don't smoke an entire brisket at a job interview, it's a lot of equipment to bring in, it takes a really long time to do it right and those conference rooms have notoriously poor ventilation
Someone smoking a brisket and poking it with a meat thermometer to see what the internal temperature is
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Alex Shackman @ajshackman.bsky.social · 26/09/2026
royalsocietypublishing.org/rstb/issue/3... loads of interesting work on emo expression from an all-star group of scientists
royalsocietypublishing.org
Volume 381 Issue 1959 | Philosophical Transactions of the Royal Society B | The Royal Society
Influential themed journal issues across the life sciences.
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Mark Baxter 🏳️‍🌈🧂 @markgbaxter.bsky.social · 24/09/2026
If you work with international personnel, you may want to comment on this proposed rule change that would put visa holders out of status immediately (instead of after a 60 day grace period) when their employment ends keepthe60days.com
keepthe60days.com
Keep the 60 Days: H-1B, E-3, L-1, O-1 & TN grace period
DHS proposes ending the 60-day grace period after a layoff for H-1B, E-3, L-1, O-1 and TN visa holders. Comment on USCIS-2026-0364 before November 10, 2026.
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Scientific American @sciam.bsky.social · 24/09/2026
Apple "detectives" wanted to identify a gnarly old tree growing on a remote plot of land in Maine. What they discovered was the key to a centuries-old apple mystery.
scientificamerican.com
How apple detectives solved the mystery of an ancient tree—and rewrote the history of fruit
And how they might have helped save the future of American apples
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Alex Shackman @ajshackman.bsky.social · 22/09/2026
www.cell.com/trends/cogni...
cell.com
The next generation of fear generalization
Generalizing from past experience is a fundamental feature of cognition. Although generalization has been of long-standing interest to diverse domains in psychological science, the past decade has see...
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Alex Shackman @ajshackman.bsky.social · 21/09/2026
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Alex Shackman @ajshackman.bsky.social · 21/09/2026
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Alex Shackman @ajshackman.bsky.social · 21/09/2026
this week's lab journal club h/t @dsbarra.bsky.social ... that thread of yours was the gift that keeps on keeping on. enjoy the rosy fingered tucson dawn. off to teach!
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Alex Shackman @ajshackman.bsky.social · 21/09/2026
proves MJ is alien genius level
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Mayor Zohran Kwame Mamdani @mayor.nyc.gov · 20/09/2026
Tonight, Jewish New Yorkers mark the start of Yom Kippur, the holiest day on the Jewish calendar. It is the peak of the Yamim Noraim, the Days of Awe, and an opportunity for profound reflection.
 
For those fasting — tzom kal, may your fast be easy and meaningful. 
 
And to all who observe, G'mar chatimah tovah. May you be sealed in the Book of Life for a good year to come.
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Carole with an e @crwright.bsky.social · 20/09/2026
Having lived through those years, I remember the fear many reporters faced but carried on despite all. Thank you.
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Mark Thornton @markthornton.bsky.social · 11/09/2026
The psychology job market may be showing some early signs of regaining strength, relative to last year. A week ago last year, fewer than 200 jobs had been listed - today, it is nearly 300, a figure we didn't hit till early October in '25. #psychjobs #neurojobs #academicjobs
Bar graph showing the number of academic jobs in psychology by area over the years from 2007-2026.
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Dylan Gee, PhD @dylanggee.bsky.social · 11/09/2026
The ABCD Study at Yale is hiring a new post-baccalaureate research assistant! This is a great position to gain hands-on research experience in the field and to learn more about adolescent brain and behavioral development! 🧠 @theabcdstudy.bsky.social candlab.yale.edu/sites/defaul...
candlab.yale.edu
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Alex Shackman @ajshackman.bsky.social · 10/09/2026
www.nature.com/articles/s44...
nature.com
Effects of psychosocial stress on opioid self-administration in healthy participants: a randomized, placebo-controlled crossover trial - Nature Mental Health
In this triple-blind, randomized, placebo-controlled crossover trial, Eikemo et al. tested whether acute psychosocial stress increases opioid self-administration using controlled stress induction, oxy...
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Society for Neuroscience @sfn.org · 08/09/2026
Late-breaking abstract submissions for #SfN26 are open now. Bring your most recent and exciting research to thousands of colleagues from around the world. Learn more and submit today: vist.ly/5hpjc #neurosky #neuroskyence #scisky
Logo with text: 'Neuroscience Research Matters Now More Than Ever. Submit an #SfN26 late-breaking abstract now. Neuroscience 2026'.
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Free Cats Daily😻 @freecatsdaily.bsky.social · 07/09/2026
He has a tattoo of his ex #Cat #Caturday
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Jonas Dora @jonasdora.bsky.social · 02/09/2026
I'm super excited to share a new preprint in which @kevinmking.bsky.social and I propose an update to the affect regulation theory of alcohol use: "A mathematical and computational formalization of the affect regulation hypothesis of alcohol use" doi.org/10.31234/osf...
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Elle Cordova @ellecordova.bsky.social · 03/09/2026
Rough Draft vs Final Draft
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Alex Shackman @ajshackman.bsky.social · 04/09/2026
but! infrastructure matters - see Suppl - shackmanlab.org/wp-content/u...
shackmanlab.org
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Alex Shackman @ajshackman.bsky.social · 04/09/2026
trainees "are uniquely placed to build communities that bridge theoretical and methodological divides" - i agree!! www.cell.com/trends/cogni...
cell.com
Science from the bottom up
How a scientific community is organized can affect whether disagreement drives progress or leads to isolation. Students and postdocs are uniquely placed to build communities that bridge theoretical an...
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Alex Shackman @ajshackman.bsky.social · 31/08/2026
it's that time of year again. time to teach, amuse, and inspire (w/ a little help from my friends)
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Alex Shackman @ajshackman.bsky.social · 30/08/2026
adding to teaching slides -
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Alex Shackman @ajshackman.bsky.social · 30/08/2026
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Alex Shackman @ajshackman.bsky.social · 30/08/2026
#AIinHigherEd - Co-brainstorm creative solutions to a last minute teaching conundrum -
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Alex Shackman @ajshackman.bsky.social · 30/08/2026
claude.com/programs/tea...
claude.com
Claude Team plan for scientists | Claude by Anthropic
Scientists at academic and nonprofit research institutions around the world can now get Claude at no cost to start. Shared projects, Claude Science, and admin controls at rates built for grant budgets...
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Alex Shackman @ajshackman.bsky.social · 28/08/2026
3/3. the blow-by-blow process, including tweak-able LLM prompts docs.google.com/document/d/1...
docs.google.com
shackman_osf_StepByExcruciatingStepf_082826.docx
ShackLab OSF Transition—Notes and Suggestions, 08-28-2026 AJ Shackman, KN Kalinova, Claude Fable, & Gemini 3.6 The OSF transition will impact all active projects in our lab. Beginning November 16, ...
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Alex Shackman @ajshackman.bsky.social · 28/08/2026
2/n. our plan - docs.google.com/document/d/1...
docs.google.com
shackman_osf-transition_hosting-plan_20260828-1407ajs.docx
Shackman Lab Public-Asset Hosting Plan after the OSF Projects Shutdown Stamp: 20260828-1407 ET. Status: Final integrated plan, revision 13 (shipped). Housekeeping pass over revision 12: vocabulary mad...
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Alex Shackman @ajshackman.bsky.social · 28/08/2026
1/3. #OSF #ShackLab #AI4OpenScience - We came up with a process and a plan for navigating the OSF transition. Links and instructions in the first 2 comments b/c FB is dumb. Feel free to redistribute. Hopefully, this will save you time, even if you simply tweak my prompts or skim the findings.
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Alex Shackman @ajshackman.bsky.social · 28/08/2026
let's see what claude and gemini suggest
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Alex Shackman @ajshackman.bsky.social · 28/08/2026
ps - gonna trial the Flashlight exercise featured in Nature's recent piece on "making better lab meetings" - stay tuned!
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Alex Shackman @ajshackman.bsky.social · 28/08/2026
Today's lab meeting: Osf transition discussion
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Alex Shackman @ajshackman.bsky.social · 27/08/2026
www.nature.com/articles/d41...
nature.com
Dolly Parton dies aged 80 — researchers celebrate her contributions to science
The country singer was an advocate for vaccines, public health, literacy and marginalized communities.
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Alex Shackman @ajshackman.bsky.social · 25/08/2026
www.sfn.org/publications...
sfn.org
Protect Scientific Peer Review: The Research Community Must Respond to NIH’s Proposal
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Drug Monkey @drugmonkey.bsky.social · 25/08/2026
From literacy for children to helping make the covid vaccine a reality, Dolly Parton was just a damn good person. A sad day. Rest in Power.
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Alex Shackman @ajshackman.bsky.social · 25/08/2026
skimmed - did not laugh. re-read at read-speed. laughed out loud
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Julia M. Rohrer @dingdingpeng.the100.ci · 24/08/2026
Actually, they tried to implement a function for THE standard error but got into trademark trouble with Ohio State University.
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Alex Shackman @ajshackman.bsky.social · 21/08/2026
www.science.org/doi/10.1126/...
science.org
Modality-specific neurovascular coupling via layer-segregated arteriole networks
The brain’s vascular system dynamically regulates energy supply through neurovascular coupling. In this study, we show that in mice, neurovascular coupling is modality-dependent: Distinct sensory inpu...
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Alex Shackman @ajshackman.bsky.social · 21/08/2026
formernih.substack.com/p/nih-direct...
formernih.substack.com
NIH Directors Decide, Except When HHS Says No
A June 2026 Nature report revealed that mandatory reviews by top officials, checking for a list of 235 disfavored terms, have left hundreds of meritorious NIH applications in administrative limbo (Koz...
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Alex Shackman @ajshackman.bsky.social · 20/08/2026
www.nature.com/articles/s41...
nature.com
A mosaic of whole-body representations on the human precentral gyrus - Nature
A comprehensive map of the human motor cortex at single-neuron resolution is described.
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Alex Shackman @ajshackman.bsky.social · 14/08/2026
4/n. and, finally, just the day before the paper popped into my feed, 🦊 was telling me about how Ben/Sarah are no longer at MN (Baylor) and what lovely talks they gave @ UCDavis :) ... our Q: are you more excited about the empirical or the methods facet?
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Drug Monkey @drugmonkey.bsky.social · 13/08/2026
Would Newton be able to submit his travel receipts for reimbursement through Concur?
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Alex Shackman @ajshackman.bsky.social · 13/08/2026
3/n. thinking about new bliss-moreau insula rev, new kwon-wager insula analysis, old mcc review, lima-dill, mobbs, pessoa -> cog did not evolve to solve stroop, but to promote fitness. fitness ~appr/avoid rew/threat. all cog is emo. SAT/GRE is a spandrel function. en.wikipedia.org/wiki/Spandre...
en.wikipedia.org
Spandrel (biology) - Wikipedia
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