Reposted by Andre FaureALLOX @alloxbio.bsky.social · 27/05/2026AI drug discovery has a data problem. We're fixing it. At ALLOX, we've spent the last few years building something that didn't exist before: a platform that systematically maps functional hotspots at scale, measuring the effects of mutations on protein-protein interactions across the proteome. 143
Reposted by Andre FaureOmar Jamshed @omarjam.bsky.social · 21/02/2026Wow. Catalonia has more active clinical trials than the entirety of the UK or Germany. That's wild. From the latest @biocat.cat annual report. 0114
Reposted by Andre FaureBen Lehner @benlehner.bsky.social · 20/02/2026The allosteric landscape of the Src kinase by Toni Beltran, @ajfaure.bsky.social , @crg.eu @sangerinstitute.bsky.social @alloxbio.bsky.social www.science.org/doi/10.1126/...science.orgThe allosteric landscape of the Src kinaseComprehensive allosteric mapping prioritizes all possible druggable surface pockets in the Src kinase for allosteric inhibition. 0205
Andre Faure @ajfaure.bsky.social · 15/02/2026Another year, another US-engineered genocide. This time in Cuba. 111
Andre Faure @ajfaure.bsky.social · 01/08/2025As the imperial boot of the US and Israel relentlessly pounds the face of the Palestinian people, the EU looks on in silence. Its inaction displays more than just stupidity and hypocrisy, the EU is complicit in genocide. www.theguardian.com/commentisfre...theguardian.comBy failing to sanction Israel, EU leaders are complicit in its crimes. They must act now | Josep BorrellEurope’s silence has allowed the genocide of Palestinians to continue unchecked – undermining all it stands for, says Josep Borrell, a former EU high representative 120
Reposted by Andre FaureBen Lehner @benlehner.bsky.social · 31/07/2025New preprint from the allostery team www.biorxiv.org/content/10.1...biorxiv.orgAllosteric and Energetic Remodeling by Protein Domain ExtensionsMany functions of proteins are performed by independently folding structural units called domains. The structures of domains are conserved during evolution but they are not identical. For example, the... 052
Reposted by Andre FaureAlbert Escobedo @albertescobedo.bsky.social · 25/07/2025🎲 Our paper on the genetics, energetics, and allostery in proteins with randomized cores and surfaces is out today @science.org! 🧬 By charting a protein’s sequence universe, we could rationalize which versions were kept through evolution – and why many stable ones were not. 13012
Andre Faure @ajfaure.bsky.social · 28/06/2025“Nothing is less real than realism. Details are confusing. It is only by selection, by elimination, by emphasis, that we get at the real meaning of things.” — Georgia O'Keeffe 010
Reposted by Andre FaureJason Hickel @jasonhickel.bsky.social · 13/06/2025On this day in 1954, the United States orchestrated a coup against Jacobo Árbenz, the progressive and democratically-elected leader of Guatemala, because he sought to restore land to small farmers and Indigenous communities that had been dispossessed by US fruit companies. 9405179
Reposted by Andre FaureAnna Arutyunyan @immunobananna.bsky.social · 12/06/2025Alzheimer’s disease 🧠starts with a molecular domino effect - but what triggers the first piece to fall? In our new study we cracked open the black box of early protein aggregation, and the findings could reshape how we fight neurodegeneration. 🧵👇 www.science.org/doi/10.1126/...science.orgMassively parallel genetic perturbation suggests the energetic structure of an amyloid-β transition stateThe aggregation rates of >140,000 mutants reveal the energetic structure of an amyloid-β nucleation reaction transition state. 1194
Andre Faure @ajfaure.bsky.social · 13/05/2025“Scientists often study the past as obsessively as historians because few other professions depend so acutely on it. Every experiment is a conversation with a prior experiment, every new theory a refutation of the old.” — Siddhartha Mukherjee, The Emperor of All Maladies 110
Reposted by Andre FaureRobert Reich @rbreich.bsky.social · 09/04/2025Any traders with inside information that Trump was going to walk back his tariffs — some of them, presumably, Trump family members and cronies — just made a fortune. It all feels like chaos until you look more closely at who is winning. 33474402058
Reposted by Andre FaureCentre de Regulació Genòmica (CRG) @crg.eu · 11/02/2025💜Feliz #11F y #DíadelaMujeryNiñaEnLaCiencia💜lavanguardia.comEl 8-M de las científicas: miles de mujeres se vuelcan para despertar vocaciones en la niñasUn movimiento imparable ha arrancado con fuerza: es el sigiloso 8-M de las científicas. Mujeres determinadas a enseñar a las chicas que pueden ser profesionales capaces 0247
Andre Faure @ajfaure.bsky.social · 30/01/2025At ALLOX @alloxbio.bsky.social in Barcelona we now have 3 computational positions available! 📌Structural Bioinformatics Scientist 👉 tinyurl.com/3rs46j4t 📌Platform Bioinformatician 👉 tinyurl.com/nyvazbke 📌Computational Chemist 👉 tinyurl.com/5n6vpem3 Apply or repost to help us spread the word 🙏 22521