iiinova — where your digital self keeps evolving

Reposted by Anna Arutyunyan

Max Stammnitz @maxstammnitz.bsky.social · 02/06/2025

1 plant hormone receptor ☘️ 3,500 mutants, to single-site saturation 🧬 >45,000 binding and abundance measurements 📶 Very happy to present our latest work – where deep mutational scanning meets the world of small molecules.   www.biorxiv.org/content/10.1...   With @benlehner.bsky.social [1/7]

biorxiv.org

The genetic architecture of an allosteric hormone receptor

Many proteins function as switches, detecting chemicals and transducing their concentrations into cellular responses. Receptor switches are key to the integration of environmental signals, yet it is n...

45023

Reposted by Anna Arutyunyan

Taylor Mighell @taylor-mighell.bsky.social · 01/06/2025

GPCR-MAPS is now live! www.biorxiv.org/content/10.1... A new platform for high resolution functional mapping of GPCRs with massive mutagenesis. We identify the core activation network, residues involved in biased signaling, and generate >7,000 full dose response curves. With @benlehner.bsky.social

biorxiv.org

The genetic architecture of G-protein coupled receptor signaling

G-protein coupled receptors (GPCRs) are the most abundant class of human receptors and drug targets. The vast majority of GPCR drugs bind the conserved orthosteric pocket, which can lead to non-specif...

1154

Anna Arutyunyan @immunobananna.bsky.social · 12/06/2025

Alzheimer’s disease 🧠starts with a molecular domino effect - but what triggers the first piece to fall? In our new study we cracked open the black box of early protein aggregation, and the findings could reshape how we fight neurodegeneration. 🧵👇 www.science.org/doi/10.1126/...

science.org

Massively parallel genetic perturbation suggests the energetic structure of an amyloid-β transition state

The aggregation rates of >140,000 mutants reveal the energetic structure of an amyloid-β nucleation reaction transition state.

1194