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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 30/09/2026

This month’s Discover ASAP features Nolwazi Gcwensa, MSc, PhD, on SynDOVE, an accessible protocol for studying synaptic proteins in 3D using confocal microscopy. 🔬 The approach can reveal changes that 2D analysis may miss, offering new insights into #Parkinsons. 📺 Watch: bit.ly/4z5OvuP

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 16/09/2026

Why does scale matter in #Parkinsons genetics? 🌍 For #OpenScienceWeek, Christine Klein, MD, of GP2 shares how harmonized datasets and shared tools can connect rare Parkinson’s cases across countries, reveal signals hidden in smaller cohorts, & inform research relevant to trials ⬇️ #ScienceForAll

Open Science Week quote graphic with a light, abstract network-pattern background and green accents. A large green “01” appears on the left, with the question at the top: “How has open science helped you share your work and access, reuse, or build upon research from others?” Below a thin green divider, Christine Klein, MD, responds: “MDSGene, built and curated in Lübeck, turns the scattered monogenic movement disorders literature into structured, queryable variant and phenotype records. We are now merging it with GP2 cohort data for aggregated cross-resource summaries neither could offer alone.”

Open Science Week quote graphic with a dark navy and green abstract network-pattern background. A large green “02” appears on the left, with the question in white at the top: “How can open science help move Parkinson’s discoveries closer to better treatments, care, or everyday outcomes?” Below a thin green divider, Christine Klein, MD, responds: “Open sharing through GP2/ASAP pools rare monogenic variant carriers across continents—the only way to power penetrance, age-at-onset, and conversion questions that LRRK2, GBA1, and PRKN trials depend on. Openly harmonized cohorts and phenotypes let findings from one site reach clinics and trial designers everywhere.”

Open Science Week quote graphic with a light, abstract network-pattern background and green accents. A large green “03” appears on the left, with the question at the top: “How has access to another researcher’s data, methods, tools, or resources influenced the direction of your own work?” Below a thin green divider, Christine Klein, MD, responds: “GP2’s openly shared NIH Oxford Nanopore pipeline reshaped which structural variants and repeat expansions we can validate. Openly harmonized cross-ancestry GP2 releases let our Family Analysis Working Group prioritize candidate genes visible only in pooled data—genes we would never have identified from families we had access to alone.”

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 18/09/2026

As #OpenScienceWeek wraps up, hear from researchers across ASAP on how open data, shared tools, and collaboration advance #Parkinsons research. ASAP’s open science work also informs broader efforts alongside our management organization, @aligningscience.com. 🔗 Read more: bit.ly/4Am002y

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 02/09/2026

Excited to see this work from CRN Team McDonough, one of ASAP’s Tool Generation teams, take shape! 🎉 By developing & openly sharing standardized stem cell models, data & protocols, the team is creating new tools to advance #Parkinsons research.

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 31/08/2026

🔓 Open science is central to how we work year-round. Across our network, researchers share data, tools, protocols, and other resources so others can access, test, reuse, and build on new discoveries. Stay tuned as we look ahead to #OpenScienceWeek, Sept. 14–18.

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 28/08/2026

This month’s Discover ASAP features Madeline Klinger, PhD, with Korbin Kleczko, BS, of CRN Team Harper 🧪 They share Q-DOAS, a proximity-quenching assay that detects early protein aggregation in real time, giving researchers a new tool to study α-synuclein and #Parkinsons. bit.ly/4zFOuyP

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 21/08/2026

A large-scale sequencing preprint analyzed data from more than 38,000 people across 11 genetic ancestries to map repeat expansions associated with Parkinson’s disease and parkinsonism. 🔗 Read the #preprint: bit.ly/4i8dkAW

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 21/08/2026

A POLG-focused preprint examined variants across diverse ancestries, identifying five Parkinson’s cases with potentially biallelic pathogenic or likely pathogenic variants. 🔗 Read the #preprint: bit.ly/4zcVpiO

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 21/08/2026

📣 New GP2 research on rare variants, repeat expansions, and molecular drivers explores genetic contributors to #ParkinsonsDisease that can be difficult to detect. Explore three preprints in the thread.

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 12/08/2026

🔁 Four new CRN preprints examine α-synuclein pathology, disease modeling tools, nervous system regeneration, and motor-circuit changes during progressive Parkinsonism.

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 06/08/2026

CRN Team Biederer introduced SynDOVE, a protocol using confocal microscopy and 3D surface rendering to quantify synaptic loci density and pre- and postsynaptic volumes in fixed brain tissue. 🔗 Read the #publication: bit.ly/4yJGoET

Protocol to study synapse density or volume-SynDOVE-in brain using confocal microscopy and Imaris three-dimensional surface rendering.

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 06/08/2026

🧠 New circuitry research from CRN teams highlights how synaptic analysis and anatomical mapping can deepen understanding of #ParkinsonsDisease-relevant brain regions and inform more precise interventions.

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 31/07/2026

CRN Team Jakobsson introduced TEsingle, a single-cell tool that tracks gene and transposable element expression, revealing elevated TE activity in specific neurons, astrocytes, and microglia from Parkinson’s disease patients. 🔗 Read the #preprint: bit.ly/4ytBuvz

TEsingle enables accurate expression quantification of genes while also providing TE-related information (Forcier et al., 2026).

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 31/07/2026

CRN Team Chen showed that Parkin is critical for neuronal differentiation, survival, and stress resistance, and developed small-molecule Parkin agonists that protect dopaminergic neurons. 🔗 Read the #preprint: bit.ly/4yAjOhR

Parkin loss results in disrupted transcriptomes and lineage-specific gene expression programs (Gong et al., 2026).

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 31/07/2026

📣 New neuroimmune research from CRN teams explores how cellular state, transposable element activity, and human organoid models can deepen understanding of #Parkinson’s disease biology.

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 16/07/2026

📣 New genomics research from CRN teams highlights how cellular models, single-cell atlases, and analytical tools can reveal shared and subtype-specific biology across #ParkinsonsDisease 🧠📈

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 24/06/2026

Check out this new #preprint from CRN Team Strick exploring how cardiac-sympathetic activity helps regulate action restraint during reward- and loss-driven decision-making tasks. 🔗 Read the full preprint: bit.ly/4eKazUo

Cardiac contractility dynamics during incentivized reaching.

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 01/07/2026

New #preprint from CRN Team Vila explores GABAergic cell clusters in the human midbrain. By identifying inhibitory neurons in the RMTg and RRF, the team lays the groundwork for studying their role in #neurodegenerative diseases. 🔗 Read the full preprint: bit.ly/4vbmGPx

Cytoarchitectural identification of the RMTg and RRF/PBP lateral GABAergic cell cluster (LatC) in the human midbrain.

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 23/06/2026

#TeamTuesday 🧫 CRN Team Ulusoy, one of our new Tool Generation teams, is developing labeled antibodies to better detect and measure mitochondrial and oxidative stress pathways in #Parkinsons disease, improving how researchers visualize disease biology. Follow the series👇 🔗 bit.ly/4nGXjD1

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 16/06/2026

#TeamTuesday 🔍 CRN Team McDonough, one of our new Tool Generation teams, is creating high-quality iPSC models with precise gene edits to study #Parkinson’sDisease. Built for reproducibility — and to be shared widely across the field. Follow along 👇 🔗 bit.ly/4tOFTpx

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 09/06/2026

#TeamTuesday 🧠 CRN Team Koob, one of our new Tool Generation teams, is developing full human gene replacement mouse models for #ParkinsonsDisease. New models designed to better reflect human biology and support translational research. More spotlights ahead 👇 🔗https://bit.ly/4ug5TuV

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 10/06/2026

This month’s Discover ASAP features Talitha Forcier of CRN Team Jakobsson. Talitha uses TEsingle, a machine learning tool that maps transposable element expression at single-cell resolution, to uncover how these genomic elements may contribute to #Parkinsons & neuroinflammation. 📺 : bit.ly/4vCxjeV

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 11/06/2026

The CRN Cloud is expanding how Parkinson’s researchers access and analyze multi-omics data. Explore how CRN Cloud now supports interoperability with AMP® PDRD and GP2, plus CURTAIN, an open-source tool for navigating proteomics data 🧪 Read the blog: bit.ly/4fDFF14

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 04/06/2026

The Collaborative Research Network is built on team science. A new Alzforum article highlights how CRN investigators are working across institutions and disciplines to advance #Parkinson’s disease research through shared tools, data, and expertise. Read more: bit.ly/4dj8ePI

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 03/06/2026

🧪 Meet the 2025 MoMa Awardees! ASAP has selected 9 CRN researchers to lead multi-omics meta-analysis projects using CRN Cloud data, advancing genetic insight, new analytical tools, and therapeutic discovery in #ParkinsonsDisease. 🔗 Learn more: bit.ly/4u9idMw

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 02/06/2026

#TeamTuesday 🧬 CRN Team Gijsbers, one of our new Tool Generation teams, is building a viral vector toolbox to enable precise gene knockdown, knockout, and overexpression across models, expanding how researchers study disease mechanisms in #Parkinsons. Follow the series 👇 🔗 bit.ly/4vwL9PZ

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 14/05/2026

New tools. Shared globally. Built to move #Parkinsons research forward. A new blog explores CRN Tool Generation teams developing CRISPR-engineered cell lines, viral vectors, chemical probes, and more. Follow along for upcoming #TeamTuesday spotlights 👇 🔗 bit.ly/4tx24Aa

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 18/05/2026

This month’s Discover ASAP features CRN Team Voet's @olgasigalova.bsky.social, Alexandra Pančíková, @juliedeman.bsky.social, & Koen Theunis 🧪 They share a dataset linking non-coding variants to cell type–specific gene regulation in the brain, revealing how genetic risk shapes #PD bit.ly/4trTmmN

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 26/05/2026

#TeamTuesday Team Fraser is developing small-molecule tools for Parkinson’s targets using structure-based and computational approaches. These probes will help researchers better understand target biology and accelerate discovery. More teams each week 👇 🔗 bit.ly/4wL2GoX

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 11/05/2026

In a new #preprint from CRN Team Lee, metabolic stress reveals a hidden layer of vulnerability in G2019S LRRK2 mice, driving widespread disruptions in nucleotide and energy metabolism and amplifying mitochondrial dysfunction. 🔗 Check out the full preprint: bit.ly/4d2P5jC

Pre-existing metabolic syndrome and G2019S LRRK2 synergistically disrupt lung metabolism.

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 28/04/2026

📢 Unraveling Parkinson’s. Advancing Precision Medicine. New CRN grants in partnership with The Michael J. Fox Foundation for Parkinson’s Research bring together 32 global teams to map the biology of #ParkinsonsDisease and build tools to accelerate discovery. 🔗 Learn more: bit.ly/4ugkfes

Graphic with a light purple gradient background featuring the headline: “Unraveling Parkinson’s. Advancing Precision Medicine.” Subhead reads: “Mapping the biological blueprint of Parkinson’s disease and building global research resources.” Along the bottom are logos for ASAP (Aligning Science Across Parkinson’s), the Collaborative Research Network (CRN), and The Michael J. Fox Foundation for Parkinson’s Research.

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allen institute @alleninstitute.org · 03/04/2026

Glia gang, this is for you! In this video by our #ElectronMicroscopy team, shows a pyramidal neuron (PyC) surrounded by 8 glia brain cells – 5 microglia (MG) and 3 oligodendrocyte progenitor cells (OPC). 🧠📈 microns-explorer.org

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 06/01/2026

GP2 just launched a new, #FreeCourse: Whole-Genome Sequencing (WGS) Data Analysis! Build your skills in navigating WGS data from raw reads to validated genetic findings. Learn how these tools advance #ParkinsonsDisease genetics 🧪 Create an account: bit.ly/4nJfarZ Take the course: bit.ly/46IASX9

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