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Alfonso De Stefano

@adestefano.bsky.social
186 followers 262 following 27 posts

MD, PhD. GI Medical Oncologist - Experimental Clinical Abdominal Oncology Unit, Istituto Nazionale Tumori - IRCCS -Fondazione G. Pascale, Napoli, Italy #ESMO #ISLB member #OncSky #GIonc

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Alfonso De Stefano @adestefano.bsky.social · 20/10/2025
Confirmed great data from #8HW trial at #ESMO25 with the combination NIVO+IPI confirms the standard of care option in 1st line MSI-H/dMMR mCRC patients @oncodaily.bsky.social
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Alfonso De Stefano @adestefano.bsky.social · 18/01/2025
Thanks 🙏🏻 to @oncodaily.bsky.social to highlight the results of #IMPROVE trial Intermittent or Continuous FOLFIRI + Panitumumab RAS and BRAF Wild-Type Metastatic #CRC #GIonc #OncSky oncodaily.com/blog/panitum...
oncodaily.com
Intermittent or Continuous FOLFIRI + Panitumumab RAS and BRAF Wild-Type Metastatic CRC - OncoDaily
Intermittent or Continuous FOLFIRI + Panitumumab RAS and BRAF Wild-Type Metastatic CRC / Akhil Santhosh, Alberto Sobrero, Alessandra Leone, Alfonso De
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Dr Joseph McCollom DO @realbowtiedoc.bsky.social · 16/01/2025
Exciting #GIonc INFINITY ♾ #Ph2 trial Neoadjuvant #IO in #stcsm #esocsm using #treme + #durva ~60% pCR 12m 🚫🔪#survival ~ 64%. #Ph3 data needed, but organ preservation possible! 🔗: sciencedirect.com/science/arti...
sciencedirect.com
Tremelimumab and durvalumab as neoadjuvant or non-operative management strategy of patients with microsatellite instability-high resectable gastric or gastroesophageal junction adenocarcinoma: the INF...
In resectable gastric/gastroesophageal junction adenocarcinoma, microsatellite instability-high (MSI-H) confers improved survival, but limited benefit…
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Mike Pishvaian @mpishvaian.bsky.social · 11/01/2025
#GI25 @ascocancer.bsky.social For #colorectalcancer, there are many great abstracts-so this is just a few to🔦: Pre-op: 1⃣@CQvortrup🗣️a Single-cycle of neoadj pembro for Stage I-III MMRdef CRC, Oral Abs 19 2⃣@jonathanloree🗣️using ctDNA🩸to support Non-Op management in rectal cancer, Oral Abs 20
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Mike Pishvaian @mpishvaian.bsky.social · 11/01/2025
#GI25 @ascocancer.bsky.social The BIG trial in #colorectalcancer will be Scott Kopetz 🗣️BREAKWATER, the 1st line R-Ph3 trial of encorafenib + cetuximab + chemotherapy in BRAF V600E-mutant met CRC, Oral Abs 16
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Mike Pishvaian @mpishvaian.bsky.social · 11/01/2025
#GI25 @ascocancer.bsky.social And 3 immunotherapy trials in #MCRC: 1⃣Thierry Andre🗣️the LBA of Ipi-Nivo vs Nivo of dMMR mCRC, ABS LBA143 2⃣ Marwan Fakih🗣️a Ph2 trial of BOT +/- Bal in MSS mCRC (no liver mets), Oral Abs 23 3⃣Joel R Hecht🗣️a Ph2 trial of a personalized Neo-Ant IO for MSS CRC, Abs LBA13
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Dr Joseph McCollom DO @realbowtiedoc.bsky.social · 14/01/2025
#GIonc summary top 3 trials in #crcsm 🥇: NICHE-2 - 99% #ORR, 100% 3-year DFS in dMMR colon cancer with ⬇️ #tox 🥈: KRYSTAL-1 - adagrasib in KRAS G12C cancers ➡️ FDA approval + cetux 🥉: TransMet - transplant + 💉 improves 5y #OS 🔗: nature.com/articles/s41...
nature.com
Moving towards more personalized approaches in locally advanced and metastatic colorectal cancer - Nature Reviews Gastroenterology & Hepatology
Colorectal cancer remains a challenging heterogeneous disease with substantial morbidity and mortality. However, progressive advances over the past year have led to marked improvements and overcome ch...
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Alfonso De Stefano @adestefano.bsky.social · 12/01/2025
Neo-adjuvantFOLFOX+/- #panitumumab for pts with KRAS-wt locally advanced #coloncancer: FOxTROT Trial www.annalsofoncology.org/article/S092... ➡️ @jenseligmann.bsky.social #GIonc @oncoalert.bsky.social 👉⬇️recurrence 12% vs 21%(HR=0.51,p0.09),significant in EREG/AREG ⬆️ 👉⬆️TOX G3 diarrhoea and rash
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Alfonso De Stefano @adestefano.bsky.social · 12/01/2025
PD-1 blockade with Tislelizumab+chemoradiotherapy in unselected MMR locally advanced #rectalcancer doi.org/10.1038/s415... @natmedicine.bsky.social ✅The pCR rates were 27.1%, 32.7% and 14.0% for experiment groups A and B and the control group C, respectively
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Victor Javier @vjsanchez.bsky.social · 11/01/2025
Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer 🧪 #PancreaticCancer febs.onlinelibrary.wiley.com/doi/10.1002/...
febs.onlinelibrary.wiley.com
FEBS Press
Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are ...
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Mike Pishvaian @mpishvaian.bsky.social · 11/01/2025
#GI25 @ascocancer.bsky.social Finally, two additional abstracts to watch for in #cholangiocarcinoma: 1⃣Dr. Priyanshi Shah🗣️Long-term outcomes for MSI-H BTC patients on immunotherapy, Abs 592; Post#C18 2⃣Dr. Christos Fountzilas🗣️🎯FGFR in the Ph2 trial of Tinengotinib for BTC Pts, Abs 608; Post#D9
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Mike Pishvaian @mpishvaian.bsky.social · 11/01/2025
#GI25 @ascocancer.bsky.social 3⃣abstracts🔬outcomes of Pts with specific🧬alterations in #cholangiocarcinoma: 1⃣&2⃣look at MDM2amp BTC: ➡️Dr. Iyer, Abs 544; Post#A22 ➡️Teresa Macarulla, Abs 615, Post#D16 3⃣Richard Kim🗣️Real-World OS in BTC Pts with IDH1mut or FGFR2fus + BTC, Abs 548; Post#A26
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Alfonso De Stefano @adestefano.bsky.social · 11/01/2025
Many thanks to @mpishvaian.bsky.social to share his top abstract titles of the upcoming #GI25 @ascocancer.bsky.social #GIonc
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Alfonso De Stefano @adestefano.bsky.social · 11/01/2025
A-REPEAT trial: #panitumumab based #rechallenge strategy in pretteated metastatic #crc pts. The study was closed prematurely but highlights the importance of #LiquidBiopsy before rechallenge:48% of pts were RAS mutant #GIonc #OncSky @christianrolfo.bsky.social www.sciencedirect.com/science/arti...
sciencedirect.com
Anti-EGFR re-challenge with chemotherapy in RAS wild-type advanced colorectal cancer (A-REPEAT study): efficacy and correlations with tissue and plasma genotyping
Approved treatments for colorectal cancer (CRC) patients pretreated with two lines of therapy are of limited efficacy. Anti-epidermal growth factor re…
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The OncoAlert Network 🚨 @oncoalert.bsky.social · 10/01/2025
The OncoAlert🚨 Network along with our partners at ESSO, ESGO, MASCC & SIOG invite you to the #OncoAlertColloquium REGISTER for FREE HERE👉 buff.ly/3CChgre February 3-9, 2025 💯% Virtual & Interactive @erikahamilton9.bsky.social @drsgraff.bsky.social @drjnaidoo.bsky.social @hoperugo.bsky.social
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Alfonso De Stefano @adestefano.bsky.social · 06/01/2025
Interesting review on advances in targeting 🎯#KRAS in #mCRC Development of KRAS Inhibitors and Their Role for Metastatic Colorectal Cancer by Dr.Dustin Deming on #JNCCN jnccn.org/view/journal... @oncoalert.bsky.social @oncodaily.bsky.social @medicalwatch.bsky.social
jnccn.org
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Toni Choueiri, MD @drchoueiri.bsky.social · 04/01/2025
www.nature.com/articles/d41... The Landscape of @fda.gov drug approvals in 2024. 30% Oncology novel drugs !
nature.com
2024 FDA approvals
The FDA approved 50 new therapeutics in 2024, with green lights for a novel schizophrenia drug, a first NASH medicine and much more.
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Alfonso De Stefano @adestefano.bsky.social · 01/01/2025
Happy New Year to everyone! @oncodaily.bsky.social @oncoalert.bsky.social @medicalwatch.bsky.social @katesears.bsky.social
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Alfonso De Stefano @adestefano.bsky.social · 30/12/2024
📢Very useful suggestions from @medicalwatch.bsky.social @katesears.bsky.social directly forwarded to your📁📬email. You can subscribe to get a monthly update on phase 3 interventional clinical trials recruiting near you on your field of interest. Congrats and thanks for this project!👏🏻💪🏻 #OncSky #GIonc
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Alfonso De Stefano @adestefano.bsky.social · 30/12/2024
Another issue on the role of #LiquidBiopsy in #CRC 👉 In these patients with stage II-IV CRC who underwent curative-intent resection,the benefit of adding serial tumor-informed ctDNA assay to the standard surveillance was limited #ISLB #GIonc @oncoalert.bsky.social jamanetwork.com/journals/jam...
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The OncoAlert Network 🚨 @oncoalert.bsky.social · 24/12/2024
Dear Colleagues, Wishing you hashtag#MerryChrismas2024 & Happy Holidays from All of us at OncoAlert 🚨 @elisaagostinetto.bsky.social @drjnaidoo.bsky.social @lymphomadoc.bsky.social @realbowtiedoc.bsky.social @stephenvliu.bsky.social @drlestercoll.bsky.social @erikahamilton9.bsky.social
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Alfonso De Stefano @adestefano.bsky.social · 24/12/2024
Find the results in the open access paper on #JCO @ascocancer.bsky.social at ascopubs.org/doi/pdf/10.1... #OncSky #GIonc
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Alfonso De Stefano @adestefano.bsky.social · 24/12/2024
Find the results in the open access paper on #JCO @ascocancer.bsky.social at ascopubs.org/doi/pdf/10.1...
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Alfonso De Stefano @adestefano.bsky.social · 24/12/2024
🙏🏻 Grateful to @medicalwatch.bsky.social and @katesears.bsky.social to promote the results of IMPROVE trial ascopubs.org/doi/pdf/10.1... in the weekly newsletter! To be always updated on most recent trials, you can subscribe at my.medical.watch/signup
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Alfonso De Stefano @adestefano.bsky.social · 22/12/2024
A very interesting course here in Italy, very recommended to all oncology researchers @ascocancer.bsky.social
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Alfonso De Stefano @adestefano.bsky.social · 06/12/2024
#IMPROVE trial #Intermittent (I) or #Continuous (C) Panitumumab+FOLFIRI for First-Line Treatment of RAS/BRAF WT Metastatic Colorectal Cancer #oncsky #JCO ✅ Endpoint met 👉mPFS 11.2(C)vs17.5 months(I) 👉NO detrimental effect on OS 👉DCR 94.2%(C)vs91%(I) 👉Reduced toxicity ascopubs.org/doi/pdf/10.1...
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Alfonso De Stefano @adestefano.bsky.social · 21/12/2024
@oncoalert.bsky.social @medicalwatch.bsky.social Historic milestone 🎯🥇 for first-line #mCRC treatment of #BRAF V600E mut patients based on #BREAKWATER study: FDA grants Accelerated Approval to Encorafenib Plus Cetuximab and Chemo for BRAF V600E+ mCRC patients #GIonc www.fda.gov/drugs/resour...
fda.gov
FDA grants accelerated approval
The Food and Drug Administration granted accelerated approval to encorafenib.
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UT MD Anderson Cancer Center @mdanderson.bsky.social · 21/12/2024
The FDA has approved BRAFTOVI in combination with cetuximab and mFOLFOX6 for first-line treatment in patients with metastatic colorectal cancer with a BRAF V600E mutation. The approval is based on the BREAKWATER study, for which MD Anderson’s Dr. Scott Kopetz is co-PI. 1/2
fda.gov
FDA grants accelerated approval
The Food and Drug Administration granted accelerated approval to encorafenib.
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Alfonso De Stefano @adestefano.bsky.social · 21/12/2024
Great milestone 🎯🥇 for #mCRC treatment #GIonc #OncSky based on the last update clinicaltrials.gov/study/NCT046... FDA grants Accelerated Approval to Encorafenib Plus Cetuximab and Chemo for BRAF V600E+ Metastatic Colorectal Cancer www.fda.gov/drugs/resour...
clinicaltrials.gov
ClinicalTrials.gov
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PeerView @peerview.bsky.social · 20/12/2024
Join Drs. Abou-Alfa, Goyal, Harding, & Prof. Vogel for a PeerView Live Symposium in collaboration with the CholangiocarcinomaFoundation.org during the #GI25 📅 Jan 23, 2025 🕕 Reg & Dinner: 6:00 PM PST 🕡 Symposium: 6:15 PM PST / 9:15 PM EST 📍 In-Person & Virtual #Medsky #Oncsky
linkedin.com
Accelerating Innovation in Biliary Tract Cancer | LinkedIn
Join Us for a Live In-Person and Virtual Symposium on "Accelerating Innovation in Biliary Tract Cancer" during the 2025 ASCO® Gastrointestinal Cancers Symposium. 📅 Thursday, January 23, 2025 🕤 6:00-6...
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OncLive @onclive.bsky.social · 17/12/2024
ctDNA, Neoadjuvant Immunotherapy Combos Could Help Reshape Management of CRC @fredhutch.bsky.social #crcsm #oncology www.onclive.com/view/ctdna-n...
onclive.com
ctDNA, Neoadjuvant Immunotherapy Combos Could Help Reshape Management of CRC
Stacey A. Cohen, MD, provides an overview on the current landscape of immunotherapies and prognostic tools in the treatment of colorectal cancer.
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Alfonso De Stefano @adestefano.bsky.social · 14/12/2024
Happy to find ASCO @ascocancer.bsky.social here on @bsky.app We were waiting for this day! A faster opportunity to get in touch with colleagues and another encouraging opportunity to share news! #OncSky #GIonc
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Brittany Harvey @brittanyeharvey.bsky.social · 17/12/2024
New guideline just out from ASCO on systemic therapy for stage I-III anal squamous cell carcinoma #ASCOguidelines #MedSky #OncSky ascopubs.org/doi/full/10....
ascopubs.org
Systemic Therapy for Stage I-III Anal Squamous Cell Carcinoma: ASCO Guideline
ASCO Guidelines provide recommendations with comprehensive review and analyses of the relevant literature for each recommendation, following the guideline development process as outlined in the ASCO G...
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Alfonso De Stefano @adestefano.bsky.social · 16/12/2024
#OncSky #GIonc
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OncoDaily @oncodaily.bsky.social · 16/12/2024
SWOG S1815 shows no OS benefit for nab-paclitaxel in BTCs - Rachna T. Shroff @rachnatshroff.bsky.social oncodaily.com/science/rach... #AdvancedBiliaryCancer #BTCResearch #Cancer #Medicine #GemcitabineCisplatin #JCO #ASCO #NabPaclitaxel #Health #OncoDaily #Oncology #SWOG #S1815
oncodaily.com
Rachna T. Shroff: SWOG S1815 shows no OS benefit for nab-paclitaxel in BTCs - OncoDaily
Rachna T. Shroff: SWOG S1815 shows no OS benefit for nab-paclitaxel in BTCs / advanced biliary cancer, Ben Westphalen, Biliary tract cancers, BTC research,
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Alfonso De Stefano @adestefano.bsky.social · 16/12/2024
my.medical.watch The weekly newsletter on CRC is now available for subscribers @medicalwatch.bsky.social @katesears.bsky.social
my.medical.watch
Medical.watch
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Alfonso De Stefano @adestefano.bsky.social · 14/12/2024
Happy to find ASCO @ascocancer.bsky.social here on @bsky.app We were waiting for this day! A faster opportunity to get in touch with colleagues and another encouraging opportunity to share news! #OncSky #GIonc
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Alfonso De Stefano @adestefano.bsky.social · 13/12/2024
Nivolumab/Ipilimumab vs Chemotherapy With or Without Targeted Agents in MSI-H or dMMR Metastatic Colorectal Cancer #OncSky #GIonc @ascopost.bsky.social ascopost.com/news/decembe...
ascopost.com
Nivolumab/Ipilimumab vs Chemotherapy With or Without Targeted Agents in MSI-H or dMMR Metastatic Colorectal Cancer
As reported in The New England Journal of Medicine by Andre et al, interim analysis of the phase III CheckMate 8HW trial has shown that nivolumab plus ipilimumab prolonged progression-free survival vs...
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Lizzy Smyth @lizzysmyth.bsky.social · 11/12/2024
We've spent 2024 discussing RT trial results in gastroesophageal cancer. My radiation oncology mate Som helps me make sense of it all below... 2024 Top Story in Oncology: The Role of Radiotherapy in Operable Gastro-Oesophageal and Gastric Cancer — Time for Change prac.co/l/22cfph7u
prac.co
2024 Top Story in Oncology: The Role of Radiotherapy in Operable Gastro-Oesophageal and Gastric Cancer — Time for Change
Written by Elizabeth Smyth MD Written by Somnath Mukherjee MD, MRCP, FRCR, FRCP
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Dr Joseph McCollom DO @realbowtiedoc.bsky.social · 10/12/2024
#GlobalOnc 🌎 study relevant to #GIonc #crcsm mortality ⬆️ in young adults (25–49) in 9 countries for men, 7 for women, driven by factors like obesity. More surveillance and prevention are needed‼️ 🔗: academic.oup.com/jnci/advance...
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Arndt Vogel @arndtvogel.bsky.social · 10/12/2024
KRAS Variants Associated With Survival Outcomes & Genomic Alterations in Biliary Tract Cancers @JCOPO_ASCO doi.org/10.1200/PO.2... 👉 15% of BTC w/ KRAS mut 👉 KRAS G12D: IHC 38%; EHC 37% 👉 KRASG12 > worse outcome only in IHC 🧐We need KRASvariant specific strategies @myESMO @EASLedu
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OncoDaily @oncodaily.bsky.social · 09/12/2024
Highlights from Global Cancer Movement: Challenging the Status Quo in Colorectal Cancer – Day 2 oncodaily.com/blog/global-... @manishshahmd.bsky.social #Medicine #Health #Oncology #OncoDaily #Cancer
oncodaily.com
Highlights from Global Cancer Movement: Challenging the Status Quo in Colorectal Cancer - Day 2 - OncoDaily
Highlights from Global Cancer Movement: Challenging the Status Quo in Colorectal Cancer - Day 2 / Abay Jumanov, Alma Zhylkaidarova, Amalya Sargsyan, Amil
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Alfonso De Stefano @adestefano.bsky.social · 08/12/2024
Three new Pan-Asian-Adapted Guidelines from #ESMOAsia2024 #BTC #OncSky #GIonc dailyreporter.esmo.org/esmo-asia-co...
dailyreporter.esmo.org
Three new Pan-Asian-adapted guidelines at ESMO Asia Congress
The latest tumour types covered in the ESMO PAGAs are biliary tract cancers, oncogene-addicted metastatic NSCL cancer and epithelial ovarian cancer
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Alfonso De Stefano @adestefano.bsky.social · 07/12/2024
Interesting paper on #JAMA Oncology: long-term colorectal cancer incidence according to negative colonoscopy screening results and individuals’ risk profiles #OncSky #GIonc ja.ma/41o4Eyk
ja.ma
Negative Screening Results and Colorectal Cancer
This cohort study compares the long-term risk of colorectal cancer incidence and mortality among individuals receiving a negative colonoscopy screening result with those not undergoing endoscopy.
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Alfonso De Stefano @adestefano.bsky.social · 06/12/2024
#IMPROVE trial #Intermittent (I) or #Continuous (C) Panitumumab+FOLFIRI for First-Line Treatment of RAS/BRAF WT Metastatic Colorectal Cancer #oncsky #JCO ✅ Endpoint met 👉mPFS 11.2(C)vs17.5 months(I) 👉NO detrimental effect on OS 👉DCR 94.2%(C)vs91%(I) 👉Reduced toxicity ascopubs.org/doi/pdf/10.1...
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STITCHES Medicine - the Best of Medical Research @medicine.stitches.today · 01/12/2024
Intermittent treatment with FOLFIRI plus panitumumab reduced toxicity and maintained effectiveness in colorectal cancer patients. by Avallone A, Giuliani F (...) Budillon A et 23 al. in J Clin Oncol #MedSky 📖 read the article: ascopubs.org/doi/10.1200/JCO.24.009…
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Angela Cochran @acochran12733.bsky.social · 24/11/2024
New in #JCO Intermittent or Continuous Panitumumab Plus Fluorouracil, Leucovorin, and Irinotecan for First-Line Treatment of RAS and BRAF Wild-Type Metastatic Colorectal Cancer: The IMPROVE Trial #MCC #openaccess #oncsky ascopubs.org/doi/10.1200/...
ascopubs.org
Intermittent or Continuous Panitumumab Plus Fluorouracil, Leucovorin, and Irinotecan for First-Line Treatment of RAS and BRAF Wild-Type Metastatic Colorectal Cancer: The IMPROVE Trial | Journal of Cli...
PURPOSETo investigate whether intermittent treatment after an induction phase of first-line schedule of fluorouracil, leucovorin, and irinotecan (FOLFIRI) plus panitumumab (PAN) prevents or delays the...
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