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Adam Fountain

@adamfountain.bsky.social
59 followers 234 following 11 posts

PostDoc in the Ramakrishnan/Luisi labs at University of Cambridge. Bedaquiline resistance in Mycobacterium tuberculosis #ENDTB

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Reposted by Adam Fountain
Lucy Weinert @lucyweinert.bsky.social · 13/12/2025
savethevetschool.co.uk Colleagues, please lend us your support. The University wants to close down the vet school despite being ranked educationally above school average and smashing the REF because they want our land and vet education is too expensive.
savethevetschool.co.uk
Save the Vet School - join 1000s of voices standing with the Vet School
A vital institution. A community in action. A future worth protecting. Stand with us to save the vet school.
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Jamie Blaza @jnb-lab.bsky.social · 12/12/2025
Our work on the mechanism of bedaquiline is now published. Nat Comms has open peer review so anyone can see the critical but constructive and supportive peer review we received. Thanks again to @morwan.me on BlueSky, and Suzy, Rowan, Greg, Chen-Li, and Roger who aren't. Original thread below
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The Washington Post @washingtonpost.com · 28/08/2025
Three senior CDC leaders who resigned told The Post they were asked to participate in an unscientific vaccine recommendation process that they believe could harm the health of Americans.
washingtonpost.com
CDC leaders who resigned said RFK Jr. undermined vaccine science, risking lives
As the CDC reels from the firing of its director, HHS Secretary Robert F. Kennedy Jr. told Fox News the agency is “in trouble and we need to fix it.”
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Simon Bullock @simonbullock11.bsky.social · 05/08/2025
Our latest work, in collaboration with the terrific @kashishsingh.bsky.social in the Carter lab @mrclmb.bsky.social is out. So proud of this study and everyone involved...
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Clockwork @watchclockwork.com · 02/07/2025
🦠 NEW VIDEO 🦠 The molecular biology of how Mycobacterium Tuberculosis evades the immune system so well. Starting with this simulation of a full outer envelope of m.TB--let's explore how the deadliest & most persistent human pathogen completely hacks our immune response. #molecularbiology
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Adam Fountain @adamfountain.bsky.social · 26/06/2025
Bedaquiline resistance driven by the MmpS5L5 efflux pump is threatening the drug regimens used to treat MDR-TB. In our new preprint, we used structural and genetic approaches to better understand how MmpS5L5 effluxes bedaquiline and how future resistance may evolve. 🧵🔽 #TBsky #MicroSky #TB
biorxiv.org
Structural and functional analysis of the Mycobacterium tuberculosis MmpS5L5 efflux pump presages a pathway to increased bedaquiline resistance
Bedaquiline, an antitubercular drug that targets ATP-synthase, is a key component of a new oral drug regimen that has revolutionized the treatment of multi drug resistant tuberculosis. Clinical bedaqu...
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Reposted by Adam Fountain
Rock Lab @rocklabtb.bsky.social · 16/05/2025
Challenging times for biomedical research in the U.S. One of our grants was terminated and two others frozen. Thinking of colleagues from Bethesda to Boston to South Africa who are facing the same uncertainty. Now more than ever, we must speak up for the value of this work.
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Reposted by Adam Fountain
Derek Lowe @dereklowe.bsky.social · 20/03/2025
Antifungal drug discovery gets an interesting and unexpected shot of good news:
science.org
A New Type of Antifungal
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Conor (Conchúr) Meehan @conmeehan.bsky.social · 05/03/2025
Statement from WHO TB program on the impact of USAID cuts. TLDR: it's devastating. hq_globaltuberculosisprogramme.cmail19.com/t/d-e-stuitu...
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Derek Lowe @dereklowe.bsky.social · 04/02/2025
A long post about what’s happening to the science funding agencies in the US and why. As mentioned, this one just kept getting longer even as I kept stripping curse words from it. www.science.org/content/blog...
science.org
What's Happening Inside the NIH and NSF
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Renee DiResta @noupside.bsky.social · 25/01/2025
Lysenkoism was a Soviet-era pseudoscientific movement led by Trofim Lysenko, and endorsed by Stalin. It rejected established genetics science in favor of politically driven, unproven agricultural theories and ideological loyalty, leading to widespread crop failures and famine.
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Saloni @scientificdiscovery.dev · 23/12/2024
Many people talk about the "Golden Age of Antibiotics", but I hadn't seen it visualized properly. Just how many types of antibiotics were discovered during that time? So, I visualized it myself!
A timeline titled "The Golden Age of Antibiotics" shows when each antibiotic drug class was first available for medical use, with example antibiotics labeled. Classes are color-coded by their source: actinomycetes, other bacteria, fungi, or synthetic. Milestones include the first antibiotics (arsphenamines in 1910), as well as the discovery of many actinomycetes-derived antibiotics, such as streptomycin, and sulfonamides, penicillins, and tetracyclines. Data: Hutchings, Truman, Wilkinson (2019). Created by Saloni Dattani for Our World in Data.
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Morwan Osman @morwan.me · 06/12/2024
Our first TB preprint with @jnb-lab.bsky.social is out! Using spectroscopic techniques from our lab, we resolve the exact mode of action of everyone's favourite TB drug, bedaquiline. I'd like to add a few comments about the microbiology part of the picture! #TBsky #MicroSky (1/7)
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Jamie Blaza @jnb-lab.bsky.social · 05/12/2024
Finally we are able to share our story on the molecular mechanism of the transformative anti-tuberculosis drug bedaquiline within living cells www.biorxiv.org/content/10.1... A (hopefully) broadly-accessible tutorial below ⬇️ (it ended up being really long!)
submit.biorxiv.org
bioRxiv Manuscript Processing System
Manuscript Processing System for bioRxiv.
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Diego del Alamo @delalamo.xyz · 27/11/2024
Chai-1, the open source AF3 clone, is now available with an Apache 2 license github.com/chaidiscover...
Chai-1 is released under an Apache 2.0 License, which means it can be used for both academic and commerical purposes, including for drug discovery.
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Jamie Blaza @jnb-lab.bsky.social · 29/11/2024
We have quite a range of PhD projects this year, covering cryo-EM methods, bacteriology/bioenergetics, and infection/antibiotics/vaccines. Would really appreciate if people can RT and share with their teams!
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Luiz Pedro Carvalho, PhD @luizcarvalholab.bsky.social · 14/11/2024
Charles Darwin and Robert Koch walked into a bar... find out the outcome of this interaction here: elifesciences.org/reviewed-pre...
elifesciences.org
A macroevolution-inspired approach to reveal novel antibiotic resistance mechanisms
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Bird account @dialecticbio.bsky.social · 03/03/2024
Been thinking about creating a collection of good protein structure figures, as inspiration for my own work. #1 www.nature.com/articles/s41...
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