The development of macrocyclic binders to therapeutic proteins has typically relied on large-scale screening methods that are resource-intensive and provide little control over binding mode. Despite c...

Protein design has focused primarily on the design of ground states, ensuring they are sufficiently low energy to be highly populated[1][1]. Designing the kinetics and dynamics of a system requires, i...

Protein design has focused primarily on the design of ground states, ensuring they are sufficiently low energy to be highly populated[1][1]. Designing the kinetics and dynamics of a system requires, i...