iiinova — where your digital self keeps evolving

Reposted by Adam Broerman

Joanna Slusky @joannas.bsky.social · 20/11/2024

If deposition becomes the norm in the field so much information will be unlocked.

Reposted by Adam Broerman

Gaurav Bhardwaj @gauravbhardwaj.bsky.social · 19/11/2024

Super excited to share the latest preprint from our lab on macrocycle binder design! Skeetorial (or whatever they are called) to follow soon. Thanks to all the amazing collaborators! www.biorxiv.org/content/10.1...

biorxiv.org

Accurate de novo design of high-affinity protein binding macrocycles using deep learning

The development of macrocyclic binders to therapeutic proteins has typically relied on large-scale screening methods that are resource-intensive and provide little control over binding mode. Despite c...

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Adam Broerman @adambroerman.bsky.social · 20/11/2024

Excited to join here and announce our new #proteindesign strategy for allosterically controlling the kinetics of protein-protein interactions! Read on for cool applications in cytokine signaling, biosensing, and protein circuits.

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