The fitness of an organism determines its likelihood of succeeding in short-term competition, but many other factors can influence its long-term success. In this study, we investigate the relative con...

The authors created a barcoded collection of 520 wild yeast strains and screened them against over 600 compounds, revealing how natural genetic variation shapes compound resistance and identifying gen...

A newly compiled atlas of species-wide structural variants and gene-based and graph pangenomes derived from highly complete assemblies of genomes from 1,086 natural isolates enable integrative genome-scale studies of Saccharomyces cerevisiae.

Female gametogenesis in Drosophila requires both differentiation of germline stem cells and the uniq

Homologous meiotic recombination starts with DNA double-strand breaks (DSBs) generated by SPO11 protein. SPO11 is critical for meiosis in most species but the DSBs it makes are also dangerous because ...