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Diepold Lab

@diepold-lab.bsky.social

165 followers 100 following 10 posts

Our group, the Department of Applied Biology at the Karlsruhe Institute of Technology, investigates bacterial secretion systems and virulence mechanisms to better understand their role in infection biology and engineer biotech and healthcare applications

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Diepold Lab @diepold-lab.bsky.social · 12/06/2026

Exciting PhD position available in the Diepold lab @kit.edu ! We're especially interested in international students with expertise in molecular biology and ready to lead a cutting-edge research project in molecular machines and infection biology. Find out more at diepoldlab.com.

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Diepold Lab @diepold-lab.bsky.social · 24/11/2025

Secreting bacteria undergo drastic changes. We found that in Yersinia, T3SS activation triggers rapid, large-scale reorganisation of chromosomal and plasmid DNA. This links secretion to growth inhibition-revealing a new connection between virulence and bacterial cell biology. doi.org/10.1016/j.ce...

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Diepold Lab @diepold-lab.bsky.social · 12/11/2025

What if even the core of bacterial nanomachines wasn’t static? We found that the T3SS core protein SctD in Yersinia dynamically exchanges subunits — and this flexibility is essential for proper assembly & function. 🔗 www.nature.com/articles/s41... @kit.edu @t3sss.bsky.social

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Diepold Lab @diepold-lab.bsky.social · 27/08/2025

We recently described how T3SS effectors reach the injectisome with a shuttle system. But what about their chaperones? With live microscopy, proximity labeling and functional assays, @keithpint.bsky.social showed the Yersinia chaperone SycH already hands over its cargo in the cytosol. bit.ly/47hq6rM

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Diepold Lab @diepold-lab.bsky.social · 20/08/2025

Using live-cell microscopy, we uncovered distinct bacterial subpopulations that primarily use certain combinations of these nanomachines: • some prioritize motility & T3SS • others shift to T6SS for antagonism All tuned by the usual suspect: cyclic di-GMP.

That's how we think Pseudomonas aeruginosa uses the T3SS, H1-T6SS, and flagellum during infection.

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