Rishi De-Kayne @rishidekayne.bsky.social · 06/04/2026Digging in, we found these long sequences were tandem dimers and trimers of the conserved domain. These structures had been inferred from what appear to be erroneous input sequences. [3/9] 100
Rishi De-Kayne @rishidekayne.bsky.social · 06/04/2026Here's what these look like: a normal single-domain Takeout structure alongside tandem dimers and trimers from different Drosophila species. [4/9] 100
Rishi De-Kayne @rishidekayne.bsky.social · 06/04/2026To figure out what was going on, we built a pipeline to split tandem-domain proteins into their constituent parts using HMM profiles, then used phylogenetics and BLASTp to identify what each domain actually was. [5/9] 100
