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Replies

Rishi De-Kayne @rishidekayne.bsky.social · 06/04/2026

We were exploring structural conservation in Takeout proteins using the TIPS insect structure database (tips.shenxlab.com) when we hit a roadblock: some sequences were 2-3x longer than others, creating huge gaps in our alignments. [2/9]

tips.shenxlab.com

TIPS

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Rishi De-Kayne @rishidekayne.bsky.social · 06/04/2026

Digging in, we found these long sequences were tandem dimers and trimers of the conserved domain. These structures had been inferred from what appear to be erroneous input sequences. [3/9]

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Rishi De-Kayne @rishidekayne.bsky.social · 06/04/2026

Here's what these look like: a normal single-domain Takeout structure alongside tandem dimers and trimers from different Drosophila species. [4/9]

an example of a single-domain takeout copy, a dimer, and a trimer

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