iiinova — where your digital self keeps evolving

Rishi De-Kayne @rishidekayne.bsky.social · 10/09/2026

Check out some new work from our team here at @arcadiascience.com on dissecting the evolutionary signal captured by Evo2 (gLM) latent spaces thestacks.org/publications...

the two main experiments from our pub 1) using Evo2s representations of different gene families to compare how it capture variation with and between gene families, and 2) a steering experiment to determine the extent to which we can push the model to generate 'platypus-like' sequences from a human starting sequence using elements of the model's latent representation of the platypus as a steering vector.

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Reposted by Rishi De-Kayne

Wes Larson @wes-larsonak.bsky.social · 24/06/2026

We're hiring a genetics lab manager position at NOAA in Juneau, Alaska! The successful candidate will oversee day-to-day laboratory operations and contribute to the development of new molecular methods. Salary is $75-145k/yr. Email wes.larson@noaa.gov with questions www.usajobs.gov/GetJob/ViewD...

usajobs.gov

Biologist (Omics)

This position is located in the National Oceanic and Atmospheric Administration (NOAA), National Marine Fisheries Service (NMFS). Vacancies may be available in each listed location. Additional duty lo...

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Rishi De-Kayne @rishidekayne.bsky.social · 22/06/2026

🚨 #Evol2026 attendees - our team at @arcadiascience.com is hiring! We're looking to hire a computational evolutionary biologist interested in asking how and why protein sequences/structures/functions differ across the tree of life 🧬 jobs.lever.co/arcadiascien... Please share widely!

jobs.lever.co

Arcadia Science - Platform Scientist: Comparative Protein Evolution

A Bit About Us: We're Arcadia Science, an evolutionary biology company founded and led by scientists. Our mission is to turn natural innovations into real-world solutions by developing systematic and ...

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Rishi De-Kayne @rishidekayne.bsky.social · 12/06/2026

🚨 We're hiring computational evolutionary biologists! 🚨 Boosting this - industry evolutionary biology jobs don't come along often, so if you're excited to apply your computational evolutionary biology skills to cutting-edge problems, let's talk! 🧪🧬💻

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Rishi De-Kayne @rishidekayne.bsky.social · 09/06/2026

Our team at @arcadiascience.com is hiring! We're looking to hire a computational evolutionary biologist interested in asking how and why protein sequences/structures/functions differ across the tree of life 🧬 jobs.lever.co/arcadiascien... Please share widely!

jobs.lever.co

Arcadia Science - Platform Scientist: Comparative Protein Evolution

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Rishi De-Kayne @rishidekayne.bsky.social · 08/06/2026

If you use PyMOL in your work, but find its command-driven workflow a bottleneck to getting from an idea to cool analyses, check out Evan's pub: thestacks.org/publications... - Agentic PyMOL is an MCP server that allows you to carry out PyMOL analyses quickly and intuitively using natural language!

thestacks.org

Agentic PyMOL: Structural analysis in PyMOL through natural language

Agentic PyMOL is an MCP server that gives language-model agents discoverable, two-way access to a user's live PyMOL session, letting agents both manipulate molecular visualizations and read structured...

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Reposted by Rishi De-Kayne

Integration of Speciation (ESEB Special Topic Network) @speciation-network.bsky.social · 05/05/2026

Happening today: the final "Early Career Researchers in Speciation" seminar! This session features talks by Aryeh Miller on Anolis lizards 🦎 and @rishidekayne.bsky.social on speciation research in industry 📊 + we'll hear from Dr Mariana Braga in the careers Q&A ✋ 👉 find the link on our website

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Reposted by Rishi De-Kayne

Integration of Speciation (ESEB Special Topic Network) @speciation-network.bsky.social · 14/04/2026

The final "Early Career Researchers in Speciation"-themed seminar is coming up on the 5th of May! This session features talks by Aryeh Miller on Anolis lizards 🦎 and @rishidekayne.bsky.social on speciation research in industry 📊 + we'll hear from Dr Mariana Braga about her career in the Q&A ✋

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Claire Mérot @clairemerot.bsky.social · 13/04/2026

Looking forward to kicking off the seminar series of our special topic network on structural variants #SV in evolutionary biology. @eseb.bsky.social Join us in listening to Pr. Rieseberg on April 29

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Rishi De-Kayne @rishidekayne.bsky.social · 06/04/2026

New pub! We analyzed protein structures across 36 Drosophila species and found something unexpected: tandem dimers and even trimers lurking in protein structure databases that likely aren't real proteins at all. 🧵 thestacks.org/publications... [1/9]

thestacks.org

Assembly and annotation artifacts can lead to problematic protein structural inferences

Protein structures inferred by protein structure prediction algorithms have incredible potential, but can contain errors stemming from incorrect input sequences. Here, we investigate one such case in ...

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Rishi De-Kayne @rishidekayne.bsky.social · 30/03/2026

Are you an evolutionary biologist who thinks about the evolution of protein sequences/structure/function across scales? Do you want to implement your skills in industry? We’ve opened a full-time role on our platform team (think computational research group)! lnkd.in/gVE2NGaV

lnkd.in

This link will take you to a page that’s not on LinkedIn

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Rishi De-Kayne @rishidekayne.bsky.social · 24/03/2026

We have an opportunity to join our team at @arcadiascience.com jobs.lever.co/arcadiascien... We're looking for an evolutionary biologist who thinks a lot about protein evolution. If you have experience investigating genomic and amino acid sequence evolution and protein structural evolution, apply!

jobs.lever.co

Arcadia Science - Platform Scientist: Protein Evolution

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Reposted by Rishi De-Kayne

STRIVE @strivestn.bsky.social · 12/03/2026

🧬 Join the STRiVE kick-off conference (TiBE-STRiVE) July 8-10, 2026 near Porto! Registration & abstracts open: 🔹 Members: Feb 25-Apr 7 🔹 Non-members: Mar 16-Apr 7 Info: structuralvariantsstn.github.io/porto_about/ #Evolution #Genomics #Biology

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Reposted by Rishi De-Kayne

STRIVE @strivestn.bsky.social · 20/02/2026

🧬We are launching STRiVE, a @eseb.bsky.social Special Topic Network on the evolutionary role of structural genomic variation. 🗓️Std: 29/04: Online seminar w/ L. Rieseberg 8-10/07: Kick-off in Porto Join us: structuralvariantsstn.github.io #Evolution #Genomics #StructuralVariants #Biology #PopGen

structuralvariantsstn.github.io

Structural Variants ESEB Special Topic Network

ESEB Special Topic Network

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Rishi De-Kayne @rishidekayne.bsky.social · 30/01/2026

Interested in whether protein language models can learn about evolution and leverage this to predict protein structures? Check out the pub!

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Rishi De-Kayne @rishidekayne.bsky.social · 31/10/2025

I'm very excited to share that today is my last day working at UC Berkeley before I start my new position at @arcadiascience.com next week! It has been a pleasure working as a postdoc in so many amazing labs along side amazing scientists, and I can't wait to start this new chapter!

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Blair Perry @bwperry.bsky.social · 08/07/2025

I am recruiting PhD students to join my lab at MSU starting Fall 2026! Please spread the word and reach out if you are interested and/or want to learn more!

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Reposted by Rishi De-Kayne

Genome Biology and Evolution @genomebiolevol.bsky.social · 25/06/2025

Ryan, @rishidekayne.bsky.social et al. present six new chromosome-level genome assemblies for Poeciliidae, providing a foundation for studies on convergent evolution, repeat content, and demographic history. 🔗 academic.oup.com/gbe/article/17/6/evaf111/8169767 #genome #evolution

academic.oup.com

New Genome Assemblies for Poeciliidae: A Foundation for Adaptation Studies

Abstract. Multiple lineages in the family Poeciliidae have independently adapted to hydrogen-sulfide-rich springs. The independent colonizations of such sp

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Reposted by Rishi De-Kayne

PLOS Biology @plosbiology.org · 03/03/2025

Dynamics of a supergene. A study of the BC supergene in wing color morphs of the African monarch #butterfly by @rishidekayne.bsky.social &co reveals dynamic evolution of #supergene haplotypes, fueled by incomplete recombination suppression 🧪 @plosbiology.org plos.io/3DiFhnL

Top: Topology weightings across chr15 showing how the karamu haplotype is related to the klugii and orientis haplotypes. Upper panel shows three possible rooted genealogical topologies. Second panel shows weights for each topology along the chromosome, smoothed with a 20 kb span. Arrows above the plot indicate the locations of inversions. Third panel shows unsmoothed topology weightings across a 1.5 Mb region corresponding to Inversion 2. Bottom: Ancestry painting across a 100 kb region within Inversion 2, showing ancestry tracts for two homozygous karamu individuals compared to two representative individuals homozygous for the orientis and klugii haplotypes. Coding regions are indicated below the plot, with the candidate gene for background colouration yellow indicated. Green triangles represent the top 10 SNPs for background colour in our GWAS. There is evidence for recombination throughout the supergene region, and specifically in the vicinity of yellow, consistent with the hypothesis that orientis ancestry at this locus (i.e., the B allele) is associated with darker colouration in karamu individuals.

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Reposted by Rishi De-Kayne

Dmitri Petrov @petrovadmitri.bsky.social · 14/01/2025

Happy that this paper - www.biorxiv.org/content/10.1... - was accepted at Mol Ecol Res and excited about the promise of this technology to measure pop sizes for such elusive species as snow leopards + learn about at least 1st-degree relationships + beyond? Congrats to Katie Solari and other authors!

biorxiv.org

Next-generation snow leopard population assessment tool: multiplex-PCR SNP panel for individual identification from feces

Snow leopards, Panthera uncia , are under threat from numerous pressures and are the focus of a great deal of conservation efforts. However, their elusive nature makes it difficult to estimate populat...

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Reposted by Rishi De-Kayne

Molly Schumer @mollyschumer.bsky.social · 15/05/2024

Thrilled to share a new lab pre-print from graduate student Tris Dodge! Tris & co elegantly uncover the genetic underpinnings and fitness consequences of a sexual mimicry polymorphism in Xiphophorus birchmanni: www.biorxiv.org/content/10.1...

biorxiv.org

Complex structural variation and behavioral interactions underpin a balanced sexual mimicry polymorphism

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

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Rishi De-Kayne @rishidekayne.bsky.social · 06/05/2024

Excited to share our review paper "Why Do Some Lineages Radiate While Others Do Not? Perspectives for Future Research on Adaptive Radiations" which is now online here: cshperspectives.cshlp.org/content/earl... Check it out for all things adaptive radiation! 🐟🦎🌿🦋

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Rishi De-Kayne @rishidekayne.bsky.social · 03/10/2023

Hi everyone! It's about time I introduced myself - I'm Rishi and I'm doing a Postdoc at UC Santa Cruz working on adaptation genomics in Poeciliid fishes and Danaus butterflies. I'm particularly the role(s) of structural variation in evolution! 🧬 🧪

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