Riccardo Bocchi @bocchiric.bsky.social · 31/07/20252/ Here is the twist 🧬. Using high-throughput clonal tracing (TrackerSeq), we discovered that these subtypes originate from two molecularly distinct radial glia lineages. 100 0
Riccardo Bocchi @bocchiric.bsky.social · 31/07/20253/ Lineage 1 🟦: Emx1⁺ radial glia → neurons first, astrocytes later. Lineage 2 🟥: Emx1⁻ radial glia → few neurons, mostly astrocytes. Each lineage gives rise to different astrocyte subtypes — with unique locations and functions. 100 0
Riccardo Bocchi @bocchiric.bsky.social · 31/07/20254/ Why does this matter? Because astrocyte origin shapes astrocyte function. Olig2-lineage astrocytes are synaptogenic — they promote synapse formation. Knock out Olig2, and synaptic density drops. 100 0
