Riccardo Bocchi @bocchiric.bsky.social · 31/07/20251/ Not all astrocytes are created equal. We mapped the molecular and spatial landscape of astrocytes in the mouse neocortex — and found five distinct subtypes, organized across cortical layers and white matter. 100
Riccardo Bocchi @bocchiric.bsky.social · 31/07/20252/ Here is the twist 🧬. Using high-throughput clonal tracing (TrackerSeq), we discovered that these subtypes originate from two molecularly distinct radial glia lineages. 100
Riccardo Bocchi @bocchiric.bsky.social · 31/07/20253/ Lineage 1 🟦: Emx1⁺ radial glia → neurons first, astrocytes later. Lineage 2 🟥: Emx1⁻ radial glia → few neurons, mostly astrocytes. Each lineage gives rise to different astrocyte subtypes — with unique locations and functions. 100
