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ME/CFS Science @mecfsscience.org · 12/10/2026

6) But there's also a second, weaker signal that points to medium spiny neurons (MSM) in the basal ganglia. This aligns with earlier analyses we did on RNA (gene expression) where MSM were among the top cell types associated with ME/CFS 👇

mecfsscience.org

Cell and tissue enrichment in ME/CFS - ME/CFS Science

By matching DNA results with gene expression databases researchers can determine the tissues and cellContinue readingCell and tissue enrichment in ME/CFS

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ME/CFS Science @mecfsscience.org · 12/10/2026

7) You can also clearly see the difference with Alzheimer or Multiple Sclerosis which have no peaks for neurons but for other cell types in the brain such as microglia or blood vessel cells. These do not show up for ME/CFS.

Horizontal bar chart of DecodeME heritability enrichment (−log10 p, S-LDSC) in the open chromatin of 42 brain cell subclasses from Li et al. 2023, coloured by class: glutamatergic neurons (blue), GABAergic neurons (orange) and non-neurons (green). The top bars are cortical intratelencephalic excitatory neurons (layer 4 and primary visual cortex, both above the Bonferroni threshold; layers 6 and 2/3 just below it) and striatal medium spiny neurons, ranked third. Glial cells, including microglia and astrocytes, show little or no signal.

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ME/CFS Science @mecfsscience.org · 12/10/2026

8 ) So this once again confirms that the DecodeME data points to neurons in the brain with a potential role for medium spiny neurons (or cells and other processes that look like it). More data and analysis here on S4ME:

s4me.info

A comparative atlas of single-cell chromatin accessibility in the human brain, Li et al, 2023 | Science for ME

Abstract Recent advances in single-cell transcriptomics have illuminated the diverse neuronal and glial cell types within the human brain. However, the...

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