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ME/CFS Science @mecfsscience.org · 12/10/2026

5) In the graph, each dot represents the results for one of the 107 cell types, while the shaded regions indicate the transition to another subclass. Like many brain traits, ME/CFS showed significant results for glutamatergic neurons such as projecting neurons from the cortex.

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ME/CFS Science @mecfsscience.org · 12/10/2026

6) But there's also a second, weaker signal that points to medium spiny neurons (MSM) in the basal ganglia. This aligns with earlier analyses we did on RNA (gene expression) where MSM were among the top cell types associated with ME/CFS 👇

mecfsscience.org

Cell and tissue enrichment in ME/CFS - ME/CFS Science

By matching DNA results with gene expression databases researchers can determine the tissues and cellContinue readingCell and tissue enrichment in ME/CFS

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ME/CFS Science @mecfsscience.org · 12/10/2026

7) You can also clearly see the difference with Alzheimer or Multiple Sclerosis which have no peaks for neurons but for other cell types in the brain such as microglia or blood vessel cells. These do not show up for ME/CFS.

Horizontal bar chart of DecodeME heritability enrichment (−log10 p, S-LDSC) in the open chromatin of 42 brain cell subclasses from Li et al. 2023, coloured by class: glutamatergic neurons (blue), GABAergic neurons (orange) and non-neurons (green). The top bars are cortical intratelencephalic excitatory neurons (layer 4 and primary visual cortex, both above the Bonferroni threshold; layers 6 and 2/3 just below it) and striatal medium spiny neurons, ranked third. Glial cells, including microglia and astrocytes, show little or no signal.

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