ME/CFS Science @mecfsscience.org · 12/10/20267) You can also clearly see the difference with Alzheimer or Multiple Sclerosis which have no peaks for neurons but for other cell types in the brain such as microglia or blood vessel cells. These do not show up for ME/CFS. 1102
ME/CFS Science @mecfsscience.org · 12/10/20268 ) So this once again confirms that the DecodeME data points to neurons in the brain with a potential role for medium spiny neurons (or cells and other processes that look like it). More data and analysis here on S4ME:s4me.infoA comparative atlas of single-cell chromatin accessibility in the human brain, Li et al, 2023 | Science for MEAbstract Recent advances in single-cell transcriptomics have illuminated the diverse neuronal and glial cell types within the human brain. However, the... 1143
ME/CFS Science @mecfsscience.org · 12/10/20269) Caveat: we're amateurs and this s-LDSC method is complex so it's possible that we made errors. We were, however, able to largely replicate results for two other traits (schizophrenia and tiredness, correlation ~ 0.99) so hopefully that means DecodeME analysis is also reliable. 2150
