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ME/CFS Science @mecfsscience.org · 12/10/2026

4) This atlas is from only 3 donors but includes 1.1 million cells from multiple brain regions. The study grouped all these cells into 107 cell types that form 42 subclasses. The authors already tested 19 diseases, we added ME/CFS genetic data as well.

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ME/CFS Science @mecfsscience.org · 12/10/2026

5) In the graph, each dot represents the results for one of the 107 cell types, while the shaded regions indicate the transition to another subclass. Like many brain traits, ME/CFS showed significant results for glutamatergic neurons such as projecting neurons from the cortex.

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ME/CFS Science @mecfsscience.org · 12/10/2026

6) But there's also a second, weaker signal that points to medium spiny neurons (MSM) in the basal ganglia. This aligns with earlier analyses we did on RNA (gene expression) where MSM were among the top cell types associated with ME/CFS 👇

mecfsscience.org

Cell and tissue enrichment in ME/CFS - ME/CFS Science

By matching DNA results with gene expression databases researchers can determine the tissues and cellContinue readingCell and tissue enrichment in ME/CFS

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