ME/CFS Science @mecfsscience.org · 12/10/20263) DNA is wrapped around proteins called histones, forming a structure known as chromatin. ATAC sequencing allows scientists to measure where the chromatin is open and where gene expression is likely taking place for each disease. 191
ME/CFS Science @mecfsscience.org · 12/10/20264) This atlas is from only 3 donors but includes 1.1 million cells from multiple brain regions. The study grouped all these cells into 107 cell types that form 42 subclasses. The authors already tested 19 diseases, we added ME/CFS genetic data as well. 191
ME/CFS Science @mecfsscience.org · 12/10/20265) In the graph, each dot represents the results for one of the 107 cell types, while the shaded regions indicate the transition to another subclass. Like many brain traits, ME/CFS showed significant results for glutamatergic neurons such as projecting neurons from the cortex. 1111
