ME/CFS Science @mecfsscience.org · 12/10/20262) The data comes from a landmark paper by Li et al. "A comparative atlas of single-cell chromatin accessibility in the human brain." It uses single-cell ATAC sequencing to show where DNA is accessible in various cells in the brain. 191
ME/CFS Science @mecfsscience.org · 12/10/20263) DNA is wrapped around proteins called histones, forming a structure known as chromatin. ATAC sequencing allows scientists to measure where the chromatin is open and where gene expression is likely taking place for each disease. 191
ME/CFS Science @mecfsscience.org · 12/10/20264) This atlas is from only 3 donors but includes 1.1 million cells from multiple brain regions. The study grouped all these cells into 107 cell types that form 42 subclasses. The authors already tested 19 diseases, we added ME/CFS genetic data as well. 191
