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ME/CFS Science @mecfsscience.org · 12/10/2026

1) 🧬 We did a new genetic analysis using DecodeME. We leveraged a database on chromatin openness in the human brain. More openness means DNA is accessible and potentially active in various cell types. The graph below shows the results for ME/CFS and various other diseases.

Stacked panels comparing ME/CFS with 19 brain-related traits: heritability enrichment (−log10 p) across 107 brain cell types from the Li et al. 2023 chromatin atlas. ME/CFS shows signal in cortical excitatory neurons and in striatal medium spiny neurons, but none in microglia or other glia; Alzheimer's disease and multiple sclerosis show the opposite pattern, with signal only in microglia and other non-neuronal cells.

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ME/CFS Science @mecfsscience.org · 12/10/2026

2) The data comes from a landmark paper by Li et al. "A comparative atlas of single-cell chromatin accessibility in the human brain." It uses single-cell ATAC sequencing to show where DNA is accessible in various cells in the brain.

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ME/CFS Science @mecfsscience.org · 12/10/2026

3) DNA is wrapped around proteins called histones, forming a structure known as chromatin. ATAC sequencing allows scientists to measure where the chromatin is open and where gene expression is likely taking place for each disease.

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