ME/CFS Science @mecfsscience.org · 16/08/20264) For those curious about the methods: we used MAGMA to convert the DecodeME data into p-values associated with genes. This is done based on position, with a window size of 0: DNA letters that fall within genes contribute to the p-value of the gene. 180
ME/CFS Science @mecfsscience.org · 16/08/20265) We can also look at the individual genes that drive these associations with synapses. For DecodeME, these included synaptic genes such as: LRRC7 STAU1 ARFGEF2 CACNAIE DCC PEBP1 VWC2 NEURL1 INA SHISA6 DENND1A NRXN1 .... etc. 170
ME/CFS Science @mecfsscience.org · 16/08/20266) One of the clearest hits in DecodeME was for the gene CA10 on chromosome 17. It's involved in neurexin binding, so it has a clear connection to other genes on the list, such as NRXN1 (neurexin 1) and NLGN1 (Neuroligin 1). 190